Cryo-EM structure of the RO5263397-bound hTAAR1-Gs complex
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8zss
Q-score: 0.398
Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F
Cell Rep (2024) 43 pp. 114505-114505 [ DOI: doi:10.1016/j.celrep.2024.114505 Pubmed: 39002128 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- The lsd-bound htaar1-gs complex (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (4~{s})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine (194 Da, Ligand)
Cryo-EM structure of the RO5263397-bound mTAAR1-Gs complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8zsv
Q-score: 0.431
Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F
Cell Rep (2024) 43 pp. 114505-114505 [ DOI: doi:10.1016/j.celrep.2024.114505 Pubmed: 39002128 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (55 kDa, Protein from Mus musculus)
- Nb35 (15 kDa, Protein from Lama glama)
- The lsd-bound htaar1-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (4~{s})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine (194 Da, Ligand)
TRPM7 structure in complex with anticancer agent CCT128930 in closed state
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 8w2l
Q-score: 0.539
Nadezhdin KD, Correia L, Shalygin A, Aktolun M, Neuberger A, Gudermann T, Kurnikova MG, Chubanov V, Sobolevsky AI
Cell Rep (2024) 43 pp. 114108-114108 [ Pubmed: 38615321 DOI: doi:10.1016/j.celrep.2024.114108 ]
- Calcium ion (40 Da, Ligand)
- Green fluorescent protein,transient receptor potential cation channel subfamily m member 7 (175 kDa, Protein from Mus musculus)
- 4-(4-chlorobenzyl)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium (342 Da, Ligand)
- Complex of trpm7 with antagonist cct128930 (700 kDa, Complex)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
MERS-CoV Nsp1 protein bound to the Human 40S Ribosomal subunit
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8t4s
Q-score: 0.59
Devarkar SC, Vetick M, Balaji S, Lomakin IB, Yang L, Jin D, Gilbert WV, Chen S, Xiong Y
Cell Rep (2023) 42 pp. 113156-113156 [ DOI: doi:10.1016/j.celrep.2023.113156 Pubmed: 37733586 ]
- 40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
- Mers-cov nsp1 bound to human 40s ribosomal subunit (Complex from Homo sapiens)
- 40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
- Fau ubiquitin-like and ribosomal protein s30 (14 kDa, Protein from Homo sapiens)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
- Replicase polyprotein 1ab (21 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- 40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- 60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- 18s rrna (602 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7w9p
Q-score: 0.456
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7w9t
Q-score: 0.431
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Human nav1.7 in complex with beta1, beta2 and huwentoxin (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of TRPV5 in nanodiscs with PI(4,5)P2 at pH6 state 1
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7t6m
Q-score: 0.578
Fluck EC, Yazici AT, Rohacs T, Moiseenkova-Bell VY
Cell Rep (2022) 39 pp. 110737-110737 [ DOI: doi:10.1016/j.celrep.2022.110737 Pubmed: 35476976 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Tetrameric assembly of trpv5 ion channel reconstituted into lipid nanodiscs (Complex from Oryctolagus cuniculus)
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7t6q
Q-score: 0.459
Fluck EC, Yazici AT, Rohacs T, Moiseenkova-Bell VY
Cell Rep (2022) 39 pp. 110737-110737 [ DOI: doi:10.1016/j.celrep.2022.110737 Pubmed: 35476976 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Tetrameric assembly of trpv5 ion channel reconstituted into lipid nanodiscs (Complex from Oryctolagus cuniculus)
- Transient receptor potential cation channel subfamily v member 5 (83 kDa, Protein from Oryctolagus cuniculus)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6xeu
Q-score: 0.549
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA
Cell Rep (2021) 36 pp. 109619- [ DOI: doi:10.1016/j.celrep.2021.109619 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- G protein-activated inward rectifier potassium channel 2 (39 kDa, Protein from Mus musculus)
- Potassium ion (39 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- G protein-gated inwardly rectifying potassium channel (girk2) (Complex from Mus musculus)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6xev
Q-score: 0.52
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA
Cell Rep (2021) 36 pp. 109619- [ DOI: doi:10.1016/j.celrep.2021.109619 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- G protein-activated inward rectifier potassium channel 2 (39 kDa, Protein from Mus musculus)
- Potassium ion (39 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- G protein-gated inwardly rectifying potassium channel (girk2) (Complex from Mus musculus)