Cryo-EM structure of the human ubiquitylated 40S ribosome with RIOK3
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8zdb
Q-score: 0.414
Huang Z, Diehl FF, Wang M, Li Y, Song A, Chen FX, Rosa-Mercado NA, Beckmann R, Green R, Cheng J
Mol Cell (2025) [ Pubmed: 39947183 DOI: doi:10.1016/j.molcel.2025.01.013 ]
- Small ribosomal subunit protein us17 (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9 (16 kDa, Protein from Homo sapiens)
- 18s rrna (602 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein es6 (28 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es30 (6 kDa, Protein from Homo sapiens)
- Ubiquitylated 40s ribosome with riok3 (Complex from Homo sapiens)
- Small ribosomal subunit protein es26 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es10 (18 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase rio3 (59 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es12 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es1 (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14 (6 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us19 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es4, x isoform (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es32 (3 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein rack1 (35 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us11 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es8 (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5 (31 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es28 (7 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es24 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es25 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es19 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ubiquitin (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us4 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es17 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us15 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es27 (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human ubiquitylated pre-40S ribosome with RIOK3
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8zdc
Q-score: 0.368
Huang Z, Diehl FF, Wang M, Li Y, Song A, Chen FX, Rosa-Mercado NA, Beckmann R, Green R, Cheng J
Mol Cell (2025) [ Pubmed: 39947183 DOI: doi:10.1016/j.molcel.2025.01.013 ]
- Small ribosomal subunit protein us17 (18 kDa, Protein from Homo sapiens)
- Rna-binding protein nob1 (46 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es6 (28 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Homo sapiens)
- Ubiquitylated pre-40s ribosome with riok3 (Complex from Homo sapiens)
- Small ribosomal subunit protein es10 (18 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase rio3 (59 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es12 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es1 (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14 (6 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us19 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es4, x isoform (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein rack1 (35 kDa, Protein from Homo sapiens)
- Protein ltv1 homolog (54 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us11 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es8 (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5 (31 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es28 (7 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es24 (15 kDa, Protein from Homo sapiens)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es25 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es19 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us4 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es17 (15 kDa, Protein from Homo sapiens)
- 18s rrna (604 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us15 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es27 (9 kDa, Protein from Homo sapiens)
- Rna-binding protein pno1 (27 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human ubiquitylated pre-40S ribosome with RIOK3 (without NOB1)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8zdd
Q-score: 0.396
Huang Z, Diehl FF, Wang M, Li Y, Song A, Chen FX, Rosa-Mercado NA, Beckmann R, Green R, Cheng J
Mol Cell (2025) [ Pubmed: 39947183 DOI: doi:10.1016/j.molcel.2025.01.013 ]
- Small ribosomal subunit protein us17 (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es6 (28 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Homo sapiens)
- Ubiquitylated pre-40s ribosome with riok3 (Complex from Homo sapiens)
- Small ribosomal subunit protein es10 (18 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase rio3 (59 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es12 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es1 (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14 (6 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us19 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es4, x isoform (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein rack1 (35 kDa, Protein from Homo sapiens)
- Protein ltv1 homolog (54 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us11 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es8 (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5 (31 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es28 (7 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es24 (15 kDa, Protein from Homo sapiens)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es25 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es19 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us4 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es17 (15 kDa, Protein from Homo sapiens)
- 18s rrna (604 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us15 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es27 (9 kDa, Protein from Homo sapiens)
- Rna-binding protein pno1 (27 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
Cryo-EM structure of human uMtCK1 in complex with ADP and covalent inhibitor CKi
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 9b16
Q-score: 0.509
Demir M, Koepping L, Li Y, Fujimoto L, Bobkov A, Zhao J, Hitosugi T, Sergienko E
Structure (2025) [ Pubmed: 39904336 DOI: doi:10.1016/j.str.2025.01.008 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- (2s)-4-(chloroacetyl)-3,4-dihydro-2h-1,4-benzoxazine-2-carboxamide (254 Da, Ligand)
- Creatine kinase u-type, mitochondrial (47 kDa, Protein from Homo sapiens)
- Octameric u-type mitochondrial creatine kinase (Complex from Homo sapiens)
The structure of type III CRISPR-associated deaminase in complex cA4
Resolution: 2.28 Å
EM Method: Single-particle
Fitted PDBs: 8z3r
Q-score: 0.605
Li Y, Li Z, Yan P, Hua C, Kong J, Wu W, Cui Y, Duan Y, Li S, Li G, Ji S, Chen Y, Zhao Y, Yang P, Hu C, Lu M, Chen M, Xiao Y
Science (2024) pp. eadr0393-eadr0393 [ DOI: doi:10.1126/science.adr0393 Pubmed: 39666823 ]
- Crispr-associated adenosine deaminase (Complex from Limisphaera ngatamarikiensis)
- Zinc ion (65 Da, Ligand)
- Adenosine deaminase domain-containing protein (70 kDa, Protein from Limisphaera ngatamarikiensis)
- 3'-o-[(r)-{[(2s,3as,4s,6s,6as)-6-(6-amino-9h-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2h-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine (658 Da, Ligand)
Cryo-EM structure of the human 40S ribosome with LARP1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xp2
Q-score: 0.462
Saba JA, Huang Z, Schole KL, Ye X, Bhatt SD, Li Y, Timp W, Cheng J, Green R
EMBO J (2024) 43 pp. 6555-6572 [ Pubmed: 39533057 DOI: doi:10.1038/s44318-024-00294-z ]
- 40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- Larp1-40s ribosome (Complex from Homo sapiens)
- 40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
- La-related protein 1 (123 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 18s rrna (602 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human 40S ribosome with LARP1 and LRRC47
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8xp3
Q-score: 0.413
Saba JA, Huang Z, Schole KL, Ye X, Bhatt SD, Li Y, Timp W, Cheng J, Green R
EMBO J (2024) 43 pp. 6555-6572 [ Pubmed: 39533057 DOI: doi:10.1038/s44318-024-00294-z ]
- 40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- Leucine-rich repeat-containing protein 47 (63 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
- La-related protein 1 (123 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 18s rrna (602 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
- Larp1-lrrc47-40s ribosome (Complex from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190.
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8y38
Q-score: 0.537
Ma CX, Li Y, Liu WT, Li Y, Zhao F, Lian XT, Ding J, Liu SM, Liu XP, Fan BZ, Liu LY, Xue F, Li J, Zhang JR, Xue Z, Pei XT, Lin JZ, Liang JH
Cell Discov (2024) 10 pp. 75-75 [ Pubmed: 38992047 DOI: doi:10.1038/s41421-024-00702-y ]
- Small ribosomal subunit protein bs20 (9 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us7 (17 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul5 (19 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us5 (17 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl27 (8 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul29 (7 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us4 (23 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul24 (11 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us12 (16 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl17 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul14 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us2 (26 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul30 (6 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs18 (9 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul13 (16 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs16 (10 kDa, Protein from Staphylococcus aureus)
- Staphylococcus aureus 70s ribosome (strain 15b196) in complex with mcx-190. (Complex from Staphylococcus aureus)
- Small ribosomal subunit protein us15 (10 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us9 (14 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul4 (22 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul18 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul2 (29 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us19 (12 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us10 (11 kDa, Protein from Staphylococcus aureus)
- Water (18 Da, Ligand)
- Large ribosomal subunit protein bl21 (11 kDa, Protein from Staphylococcus aureus)
- 16s ribosomal rna (500 kDa, RNA from Staphylococcus aureus)
- Large ribosomal subunit protein bl25 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl19 (13 kDa, Protein from Staphylococcus aureus)
- 5s ribosomal rna (36 kDa, RNA from Staphylococcus aureus)
- Small ribosomal subunit protein us14b (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl33b (5 kDa, Protein from Staphylococcus aureus)
- 23s ribosomal rna (946 kDa, RNA from Staphylococcus aureus)
- Small ribosomal subunit protein bs6 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl34 (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul6 (19 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl31b (6 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul15 (15 kDa, Protein from Staphylococcus aureus)
- Magnesium ion (24 Da, Ligand)
- 7-[4-[3-[[(1~{s},2~{r},5~{r},6~{s},7~{s},8~{r},9~{r},11~{r},13~{r},14~{r})-8-[(2~{s},3~{r},4~{s},6~{r})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid (969 Da, Ligand)
- Large ribosomal subunit protein ul3 (23 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us3 (24 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl20 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl32 (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl35 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl36 (4 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul23 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul16 (15 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul22 (12 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl28 (6 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us11 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us17 (10 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us13 (13 kDa, Protein from Staphylococcus aureus)
cryo-EM structure of Staphylococcus aureus(ATCC 29213) 70S ribosome in complex with MCX-190.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8y39
Q-score: 0.353
Ma CX, Li Y, Liu WT, Li Y, Zhao F, Lian XT, Ding J, Liu SM, Liu XP, Fan BZ, Liu LY, Xue F, Li J, Zhang JR, Xue Z, Pei XT, Lin JZ, Liang JH
Cell Discov (2024) 10 pp. 75-75 [ Pubmed: 38992047 DOI: doi:10.1038/s41421-024-00702-y ]
- Small ribosomal subunit protein bs20 (9 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us7 (17 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul5 (19 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us5 (17 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl27 (8 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul29 (7 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us4 (23 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul24 (11 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us12 (16 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl17 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul14 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us2 (26 kDa, Protein from Staphylococcus aureus)
- 23s ribosomal rna (946 kDa, RNA from Staphylococcus aureus)
- Large ribosomal subunit protein ul30 (6 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs18 (9 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul13 (16 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs16 (10 kDa, Protein from Staphylococcus aureus)
- Staphylococcus aureus(atcc 29213) 70s ribosome in complex with mcx-190. (Complex from Staphylococcus aureus)
- Small ribosomal subunit protein us15 (10 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us9 (14 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul4 (22 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul18 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul2 (29 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us19 (12 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us10 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl21 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl25 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl19 (13 kDa, Protein from Staphylococcus aureus)
- 5s ribosomal rna (36 kDa, RNA from Staphylococcus aureus)
- Small ribosomal subunit protein us14b (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl33b (5 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs6 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl34 (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul6 (19 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl31b (6 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul15 (15 kDa, Protein from Staphylococcus aureus)
- Magnesium ion (24 Da, Ligand)
- 7-[4-[3-[[(1~{s},2~{r},5~{r},6~{s},7~{s},8~{r},9~{r},11~{r},13~{r},14~{r})-8-[(2~{s},3~{r},4~{s},6~{r})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid (969 Da, Ligand)
- Large ribosomal subunit protein ul3 (23 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us3 (24 kDa, Protein from Staphylococcus aureus)
- 16s ribosomal rna (500 kDa, RNA from Staphylococcus aureus)
- Large ribosomal subunit protein bl20 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl32 (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl35 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl36 (4 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul23 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul16 (15 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul22 (12 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl28 (6 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us11 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us17 (10 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us13 (13 kDa, Protein from Staphylococcus aureus)