EDS1-SAG101-NRG1A L134E heterotrimer
Xiao Y, Wu X, Wang Z, Ji K, Zhao Y, Zhang Y, Wan L
Nature (2025) [ DOI: doi:10.1038/s41586-024-08517-3 Pubmed: 39939758 ]
- Eds1-sag101-nrg1a l134e heterotrimer (Complex from Arabidopsis thaliana)
- Probable disease resistance protein at5g66900 (92 kDa, Protein from Arabidopsis thaliana)
- [[(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-4-[(2~{s},3~{r},4~{s},5~{r})-5-[[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (1 kDa, Ligand)
- Senescence-associated carboxylesterase 101 (62 kDa, Protein from Arabidopsis thaliana)
- Protein eds1 (71 kDa, Protein from Arabidopsis thaliana)
EDS1-SAG101-NRG1C heterotrimer
Xiao Y, Wu X, Wang Z, Ji K, Zhao Y, Zhang Y, Wan L
Nature (2025) [ DOI: doi:10.1038/s41586-024-08517-3 Pubmed: 39939758 ]
- [[(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-4-[(2~{s},3~{r},4~{s},5~{r})-5-[[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (1 kDa, Ligand)
- Senescence-associated carboxylesterase 101 (62 kDa, Protein from Arabidopsis thaliana)
- Probable disease resistance protein at5g66890 (47 kDa, Protein from Arabidopsis thaliana)
- Eds1-sag101-nrg1c heterotrimer (Complex from Arabidopsis thaliana)
- Protein eds1 (71 kDa, Protein from Arabidopsis thaliana)
Cryo-EM structure of the INT-777-bound GPBAR-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7cfn
Q-score: 0.53
Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y
Nature (2020) 587 pp. 499-504 [ Pubmed: 32698187 DOI: doi:10.1038/s41586-020-2569-1 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Int-777-bound gpbar-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- G-protein coupled bile acid receptor 1 (Complex)
- Nanobody-35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunits (Complex from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- G-protein coupled bile acid receptor 1 (35 kDa, Protein from Homo sapiens)
- (2s,4r)-4-[(3r,5s,6r,7r,8r,9s,10s,12s,13r,14s,17r)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid (450 Da, Ligand)