cryo-EM structure of the human respiratory complex II
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8gs8
Q-score: 0.577
Du Z, Zhou X, Lai Y, Xu J, Zhang Y, Zhou S, Feng Z, Yu L, Tang Y, Wang W, Yu L, Tian C, Ran T, Chen H, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
PNAS (2023) 120 pp. e2216713120-e2216713120 [ DOI: doi:10.1073/pnas.2216713120 Pubmed: 37098072 ]
- Fe3-s4 cluster (295 Da, Ligand)
- Ubiquinone-1 (250 Da, Ligand)
- Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (17 kDa, Protein from Homo sapiens)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- (1s)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (720 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- The human mitochondrial complex ii, composed of sdha, sdhb, sdhc and sdhd (Complex from Homo sapiens)
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (18 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (31 kDa, Protein from Homo sapiens)
- Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (72 kDa, Protein from Homo sapiens)
- Flavin-adenine dinucleotide (785 Da, Ligand)
human KCNQ1-CaM-ML277-PIP2 complex in state A
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xnl
Q-score: 0.412
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ DOI: doi:10.1073/pnas.2207067119 Pubmed: 36763058 ]
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Human kcnq1-cam-ml277-pip2 complex in state a (Cellular component from Homo sapiens)
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
human KCNQ1-CaM-ML277-PIP2 complex in state B
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7xnn
Q-score: 0.428
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ DOI: doi:10.1073/pnas.2207067119 Pubmed: 36763058 ]
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
- Human kcnq1-cam-ml277-pip2 complex in state b (Cellular component from Homo sapiens)