ABCB1 L335C mutant (mABCB1) in the inward facing state bound to AAC
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7zk7
Q-score: 0.378
Gewering T, Waghray D, Parey K, Januliene D, Urbatsch I, Moeller A, Zhang Q
To Be Published
- (4s,11s,18s)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (692 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Atp-dependent translocase abcb1 (146 kDa, Protein from Mus musculus)
- Abcb1 (140 MDa, Complex from Mus musculus)
- (4~{s},11~{s},18~{s})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (494 Da, Ligand)
ABCB1 L971C mutant (mABCB1) in the outward facing state bound to AAC
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7zk8
Q-score: 0.511
Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90174 Pubmed: 38259172 ]
- Water (18 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Abcb1 (140 MDa, Complex from Mus musculus)
- (4~{s},11~{s},18~{s})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (494 Da, Ligand)
- Atp-dependent translocase abcb1 (140 kDa, Protein from Mus musculus)
ABCB1 V978C mutant (mABCB1) in the outward facing state bound to AAC
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7zka
Q-score: 0.533
Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90174 Pubmed: 38259172 ]
- Water (18 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Atp-dependent translocase abcb1 (146 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Abcb1 (140 MDa, Complex from Mus musculus)
- (4~{s},11~{s},18~{s})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (494 Da, Ligand)
ABCB1 V978C mutant (mABCB1) in the inward facing state
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7zkb
Q-score: 0.282
Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90174 Pubmed: 38259172 ]
- Atp-dependent translocase abcb1 (146 kDa, Protein from Mus musculus)
- Abcb1 (140 MDa, Complex from Mus musculus)
- (4~{s},11~{s},18~{s})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (494 Da, Ligand)
- (4s,11s,18s)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (692 Da, Ligand)
Cryo-EM structure of the PSI-LHCI-Lhcp supercomplex from Ostreococcus tauri
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 7yca
Q-score: 0.514
Ishii A, Shan J, Sheng X, Kim E, Watanabe A, Yokono M, Noda C, Song C, Murata K, Liu Z, Minagawa J
eLife (2023) 12 [ Pubmed: 36951548 DOI: doi:10.7554/eLife.84488 ]
- Psag (14 kDa, Protein from Ostreococcus tauri)
- Phylloquinone (450 Da, Ligand)
- Chlorophyll a-b binding protein, chloroplastic (26 kDa, Protein from Ostreococcus tauri)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- Photosystem i reaction center subunit ix (4 kDa, Protein from Ostreococcus tauri)
- Chlorophyll a-b binding protein, chloroplastic (29 kDa, Protein from Ostreococcus tauri)
- Beta-carotene (536 Da, Ligand)
- Chlorophyll a-b binding protein, chloroplastic (25 kDa, Protein from Ostreococcus tauri)
- Photosystem i psan, reaction centre subunit n (14 kDa, Protein from Ostreococcus tauri)
- Photosystem i psah, reaction centre subunit vi (17 kDa, Protein from Ostreococcus tauri)
- Psi subunit v (21 kDa, Protein from Ostreococcus tauri)
- (1r,3r)-6-{(3e,5e,7e,9e,11e,13e,15e,17e)-18-[(1s,4r,6r)-4-hydroxy-2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenylidene}-1,5,5-trimethylcyclohexane-1,3-diol (600 Da, Ligand)
- Lhca6 (26 kDa, Protein from Ostreococcus tauri)
- Photosystem i reaction center subunit ii, chloroplastic (20 kDa, Protein from Ostreococcus tauri)
- Photosystem i reaction center subunit viii (3 kDa, Protein from Ostreococcus tauri)
- Chlorophyll b (907 Da, Ligand)
- Chlorophyll c2 (608 Da, Ligand)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Photosystem i p700 chlorophyll a apoprotein a2 (81 kDa, Protein from Ostreococcus tauri)
- Water (18 Da, Ligand)
- Photosystem i-light-harvesting complex i-prasinophyte-specific lhc protein (psi-lhci-lhcp) supercomplex (Complex from Ostreococcus tauri)
- Psao (15 kDa, Protein from Ostreococcus tauri)
- Chlorophyll a-b binding protein, chloroplastic (24 kDa, Protein from Ostreococcus tauri)
- (3s,5r,6s,3's,5'r,6's)-5,6,5',6'-diepoxy-5,6,5',6'- tetrahydro-beta,beta-carotene-3,3'-diol (600 Da, Ligand)
- Photosystem i reaction center subunit iii (24 kDa, Protein from Ostreococcus tauri)
- Chlorophyll a isomer (893 Da, Ligand)
- Photosystem i reaction centre subunit iv (11 kDa, Protein from Ostreococcus tauri)
- Photosystem i p700 chlorophyll a apoprotein a1 (83 kDa, Protein from Ostreococcus tauri)
- 1,2-di-o-acyl-3-o-[6-deoxy-6-sulfo-alpha-d-glucopyranosyl]-sn-glycerol (795 Da, Ligand)
- Photosystem i reaction center subunit xii (3 kDa, Protein from Ostreococcus tauri)
- (1~{s})-3,5,5-trimethyl-4-[(3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e},17~{e})-3,7,12,16-tetramethyl-18-[(1~{r},4~{r})-2,6,6-trimethyl-4-oxidanyl-cyclohex-2-en-1-yl]octadeca-3,5,7,9,11,13,15,17-octaenyl]cyclohex-3-en-1-ol (570 Da, Ligand)
- Chlorophyll a-b binding protein, chloroplastic (23 kDa, Protein from Ostreococcus tauri)
- (3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e},17~{e})-1-[(1~{s},4~{s})-2,2-dimethyl-6-methylidene-1,4-bis(oxidanyl)cyclohexyl]-3,7,12,16-tetramethyl-18-[(1~{r},4~{r})-2,6,6-trimethyl-4-oxidanyl-cyclohex-2-en-1-yl]octadeca-3,5,7,9,11,13,15,17-octaen-2-one (600 Da, Ligand)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Chlorophyll a-b binding protein, chloroplastic (24 kDa, Protein from Ostreococcus tauri)
- Lhca1 (24 kDa, Protein from Ostreococcus tauri)
- Photosystem i iron-sulfur center (8 kDa, Protein from Ostreococcus tauri)
- Photosystem i psag/psak protein (13 kDa, Protein from Ostreococcus tauri)
- Iron/sulfur cluster (351 Da, Ligand)
- Chlorophyll a (893 Da, Ligand)
Cryo-EM structure of the Lhcp complex from Ostreococcus tauri
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8hg3
Q-score: 0.479
Ishii A, Shan J, Sheng X, Kim E, Watanabe A, Yokono M, Noda C, Song C, Murata K, Liu Z, Minagawa J
eLife (2023) 12 [ Pubmed: 36951548 DOI: doi:10.7554/eLife.84488 ]
- (1r,3r)-6-{(3e,5e,7e,9e,11e,13e,15e,17e)-18-[(1s,4r,6r)-4-hydroxy-2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenylidene}-1,5,5-trimethylcyclohexane-1,3-diol (600 Da, Ligand)
- Chlorophyll a-b binding protein, chloroplastic (24 kDa, Protein from Ostreococcus tauri)
- Chlorophyll b (907 Da, Ligand)
- Chlorophyll c2 (608 Da, Ligand)
- Prasinophyte-specific lhc protein (lhcp) complex (Complex from Ostreococcus tauri)
- Chlorophyll a (893 Da, Ligand)
- (1~{s})-3,5,5-trimethyl-4-[(3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e},17~{e})-3,7,12,16-tetramethyl-18-[(1~{r},4~{r})-2,6,6-trimethyl-4-oxidanyl-cyclohex-2-en-1-yl]octadeca-3,5,7,9,11,13,15,17-octaenyl]cyclohex-3-en-1-ol (570 Da, Ligand)
- (3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e},17~{e})-1-[(1~{s},4~{s})-2,2-dimethyl-6-methylidene-1,4-bis(oxidanyl)cyclohexyl]-3,7,12,16-tetramethyl-18-[(1~{r},4~{r})-2,6,6-trimethyl-4-oxidanyl-cyclohex-2-en-1-yl]octadeca-3,5,7,9,11,13,15,17-octaen-2-one (600 Da, Ligand)
Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7z3n
Q-score: 0.412
Kisonaite M, Wild K, Lapouge K, Gese GV, Kellner N, Hurt E, Sinning I
Nat Struct Mol Biol (2023) 30 pp. 670-677 [ Pubmed: 37081320 DOI: doi:10.1038/s41594-023-00973-1 ]
- 60s ribosomal protein l33-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s26 (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l20 (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Dolichyl-diphosphooligosaccharide--protein glycotransferase (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s7 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l36 (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l19 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s6 (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s16-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s4 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s acidic ribosomal protein p0 (33 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l28-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l41-a (3 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l23-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein s27-like protein (8 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l44-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s2-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein us14 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s27a-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 26s rrna (1 MDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s21-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l12-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l43-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s28-like protein (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s12 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s30 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s9-like protein (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l21-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El38 (9 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El24 (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s17-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l17-like protein (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l5-like protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative heat shock protein (62 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s19-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chaetomium thermophilum rac on 80s ribosome (Complex from Chaetomium thermophilum var. thermophilum DSM 1495)
- 40s ribosomal protein s3-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l26-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l25-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l13 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s5-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s10-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosome associated protein (51 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ul6 (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l27 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s15-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l30-like protein (11 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l3-like protein (44 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l32-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative guanine nucleotide-binding protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l18-like protein (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s23-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l6 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s25 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l10-like protein (25 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s11-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s20-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l4-like protein (39 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l37 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Magnesium ion (24 Da, Ligand)
- Nascent chain (2 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5s rrna (38 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein el39 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l15 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l34-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s0 (31 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s8 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l29 (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l16-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l7-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s1 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5.8s rrna (50 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l8 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l2-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s13-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Habp4_pai-rbp1 domain-containing protein (32 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 18s rrna (578 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s24 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7z3o
Q-score: 0.462
Kisonaite M, Wild K, Lapouge K, Gese GV, Kellner N, Hurt E, Sinning I
Nat Struct Mol Biol (2023) 30 pp. 670-677 [ Pubmed: 37081320 DOI: doi:10.1038/s41594-023-00973-1 ]
- 60s ribosomal protein l33-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s26 (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l20 (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Dolichyl-diphosphooligosaccharide--protein glycotransferase (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s7 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l36 (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l19 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s6 (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s16-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s4 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s acidic ribosomal protein p0 (33 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l28-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l41-a (3 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l23-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein s27-like protein (8 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l44-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s2-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein us14 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s27a-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 26s rrna (1 MDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s21-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l12-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l43-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s28-like protein (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s12 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s30 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s9-like protein (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l21-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El38 (9 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El24 (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s17-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l17-like protein (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l5-like protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative heat shock protein (62 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s19-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chaetomium thermophilum rac on 80s ribosome (Complex from Chaetomium thermophilum var. thermophilum DSM 1495)
- 40s ribosomal protein s3-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l26-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l25-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l13 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s5-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s10-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosome associated protein (51 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ul6 (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l27 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s15-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l30-like protein (11 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l3-like protein (44 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l32-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative guanine nucleotide-binding protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l18-like protein (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s23-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l6 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s25 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l10-like protein (25 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s11-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s20-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l4-like protein (39 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l37 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Magnesium ion (24 Da, Ligand)
- Nascent chain (2 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5s rrna (38 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein el39 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l15 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l34-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s0 (31 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s8 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l29 (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l16-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l7-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s1 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5.8s rrna (50 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l8 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l2-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s13-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Habp4_pai-rbp1 domain-containing protein (32 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 18s rrna (578 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s24 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7zta
Q-score: 0.565
Leroy EC, Perry TN, Renault TT, Innis CA
Nat Chem Biol (2023) 19 pp. 1091-1096 [ DOI: doi:10.1038/s41589-023-01343-0 Pubmed: 37322159 ]
- Trna-gln (24 kDa, RNA from Escherichia coli K-12)
- 50s ribosomal protein l15 (15 kDa, Protein from Escherichia coli K-12)
- Trna-lys (24 kDa, RNA from Escherichia coli K-12)
- 30s ribosomal protein s17 (9 kDa, Protein from Escherichia coli K-12)
- Structure of an escherichia coli 70s ribosome stalled by tetracenomycin x during translation of an maaapqk(c) peptide (Complex from Escherichia coli K-12)
- Trna-cys (a site) (Complex from Escherichia coli K-12)
- 30s ribosomal protein s20 (9 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s13 (12 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l23 (10 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l29 (7 kDa, Protein from Escherichia coli K-12)
- Glutamine (146 Da, Ligand)
- 5s ribosomal rna (38 kDa, RNA from Escherichia coli K-12)
- 50s ribosomal protein l14 (13 kDa, Protein from Escherichia coli K-12)
- Trna-gln (e site) (Complex from Escherichia coli K-12)
- 50s ribosomal protein l35 (7 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l4 (22 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s15 (10 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal subunit (Complex from Escherichia coli K-12)
- 30s ribosomal protein s21 (6 kDa, Protein from Escherichia coli K-12)
- Potassium ion (39 Da, Ligand)
- 50s ribosomal protein l3 (22 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s7 (16 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s9 (14 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l22 (12 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l27 (9 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l13 (16 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l16 (15 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l21 (11 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l30 (6 kDa, Protein from Escherichia coli K-12)
- Mrna (4 kDa, RNA from Escherichia coli K-12)
- Cysteine (121 Da, Ligand)
- 30s ribosomal protein s11 (12 kDa, Protein from Escherichia coli K-12)
- Trna-cys (23 kDa, RNA from Escherichia coli K-12)
- 30s ribosomal protein s5 (16 kDa, Protein from Escherichia coli K-12)
- Water (18 Da, Ligand)
- 50s ribosomal protein l25 (10 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s16 (9 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l31 (7 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s14 (11 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s2 (24 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l20 (13 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l24 (11 kDa, Protein from Escherichia coli K-12)
- Maaapqk nascent peptide (716 Da, Protein from Escherichia coli K-12)
- 30s ribosomal protein s8 (14 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s3 (23 kDa, Protein from Escherichia coli K-12)
- Magnesium ion (24 Da, Ligand)
- 23s ribosomal rna (941 kDa, RNA from Escherichia coli K-12)
- 50s ribosomal subunit (Complex from Escherichia coli K-12)
- Zinc ion (65 Da, Ligand)
- 30s ribosomal protein s4 (23 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l34 (5 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l28 (8 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l36 (4 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l2 (29 kDa, Protein from Escherichia coli K-12)
- Tetracenomycin x (486 Da, Ligand)
- 50s ribosomal protein l17 (13 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l19 (13 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s10 (11 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l32 (6 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l18 (12 kDa, Protein from Escherichia coli K-12)
- Mrna (Complex from Escherichia coli K-12)
- 50s ribosomal protein l6 (18 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l9 (15 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s19 (9 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s12 (13 kDa, Protein from Escherichia coli K-12)
- Maaapqk-trna-lys (p site) (Complex)
- 50s ribosomal protein l33 (5 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l5 (20 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s6, fully modified isoform (12 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s18 (7 kDa, Protein from Escherichia coli K-12)
- 16s ribosomal rna (497 kDa, RNA from Escherichia coli K-12)
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the arylsulfonamide inhibitor GNE-3565
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8f0r
Q-score: 0.556
Kschonsak M, Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J, Ciferri C, Tellis JC
eLife (2023) 12 [ Pubmed: 36975198 DOI: doi:10.7554/eLife.84151 ]
- Sodium channel protein pafpc1,sodium channel protein type 9 subunit alpha chimera (184 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Vsd4-nav1.7-navpas channel chimera bound to the arylsulfonamide inhibitor gne-3565 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 5-chloro-4-({(1s,2s,4s)-2-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]cyclohexyl}amino)-2-fluoro-n-(pyrimidin-4-yl)benzene-1-sulfonamide (572 Da, Ligand)