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was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

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Tissue biology and disease modelling

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Structural biology

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Epigenetics and neurobiology

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EMD-11640

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Structure of small high-light grown Chlorella ohadii photosystem I

Release date: July 28, 2021
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7a4p
Q-score: 0.278

Caspy I, Neumann E, Fadeeva M, Liveanu V, Savitsky A, Frank A, Kalisman YL, Shkolnisky Y, Murik O, Treves H, Hartmann V, Nowaczyk MM, Schuhmann W, Rogner M, Willner I, Kaplan A, Schuster G, Nelson N, Lubitz W, Nechushtai R

Nat Plants (2021) 7 pp. 1314-1322 [ DOI: doi:10.1038/s41477-021-00983-1 Pubmed: 34462576 ]

Sample:

Phylloquinone (450 Da, Ligand)
Photosystem i reaction center subunit chloroplastic (10 kDa, Protein from Chlorella ohadii)
Psi subunit v (16 kDa, Protein from Chlorella ohadii)
1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
Photosystem i p700 chlorophyll a apoprotein a2 (81 kDa, Protein from Chlorella ohadii)
Beta,beta-caroten-4-one (550 Da, Ligand)
Photosystem i reaction center subunit chloroplastic (15 kDa, Protein from Chlorella ohadii)
Chlorophyll a-b binding protein, chloroplastic (19 kDa, Protein from Chlorella ohadii)
Glutathione reductase (26 kDa, Protein from Chlorella ohadii)
Small high light grown chlorella ohadii photosystem i (900 kDa, Complex from Chlorella ohadii)
Psi-k (8 kDa, Protein from Chlorella ohadii)
Beta-carotene (536 Da, Ligand)
(3r)-beta,beta-caroten-3-ol (552 Da, Ligand)
Ergosterol (396 Da, Ligand)
Photosystem i reaction center subunit viii (3 kDa, Protein from Chlorella ohadii)
O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
Chlorophyll b (907 Da, Ligand)
(2s)-3-{[(r)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate (453 Da, Ligand)
Psi-f (18 kDa, Protein from Chlorella ohadii)
1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
Photosystem i p700 chlorophyll a apoprotein a1 (82 kDa, Protein from Chlorella ohadii)
Photosystem i iron-sulfur center (8 kDa, Protein from Chlorella ohadii)
Photosystem i reaction center subunit ix (4 kDa, Protein from Chlorella ohadii)
Chlorophyll a-b binding protein, chloroplastic (24 kDa, Protein from Chlorella ohadii)
Chlorophyll a-b binding protein, chloroplastic (25 kDa, Protein from Chlorella ohadii)
Palmitic acid (256 Da, Ligand)
(3~{e},5~{e},7~{e})-6-methyl-8-[(6~{r})-2,2,6-trimethylcyclohexyl]octa-3,5,7-trien-2-one (260 Da, Ligand)
(3s,5r,6s,3's,5'r,6's)-5,6,5',6'-diepoxy-5,6,5',6'- tetrahydro-beta,beta-carotene-3,3'-diol (600 Da, Ligand)
Chlorophyll a isomer (893 Da, Ligand)
Sphingosine (299 Da, Ligand)
1,2-di-o-acyl-3-o-[6-deoxy-6-sulfo-alpha-d-glucopyranosyl]-sn-glycerol (795 Da, Ligand)
Tripalmitoylglycerol (807 Da, Ligand)
Chlorophyll a-b binding protein, chloroplastic (23 kDa, Protein from Chlorella ohadii)
2-(2-azanylethanoylamino)ethanoic acid (132 Da, Ligand)
Chlorophyll a-b binding protein, chloroplastic (23 kDa, Protein from Chlorella ohadii)
Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
(3r,3'r,6s)-4,5-didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol (568 Da, Ligand)
Phosphatidylethanolamine (734 Da, Ligand)
Oleic acid (282 Da, Ligand)
1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
[2-((1-oxododecanoxy-(2-hydroxy-3-propanyl))-phosphonate-oxy)-ethyl]-trimethylammonium (440 Da, Ligand)
Chlorophyll a-b binding protein, chloroplastic (25 kDa, Protein from Chlorella ohadii)
Photosystem i reaction center subunit iv (7 kDa, Protein from Chlorella ohadii)
(1~{s})-3,5,5-trimethyl-4-[(1~{e},3~{e},5~{e},7~{e},9~{e},11~{e},13~{e},15~{e},17~{e})-3,7,12,16-tetramethyl-18-[(4~{s})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-en-1-ol (568 Da, Ligand)
Iron/sulfur cluster (351 Da, Ligand)
Chlorophyll a (893 Da, Ligand)
Diacyl glycerol (625 Da, Ligand)
Dodecyl-beta-d-maltoside (510 Da, Ligand)
Photosystem i reaction center subunit xii (3 kDa, Protein from Chlorella ohadii)

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EMD-10320

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IC2A cryo-EM map of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi

Release date: Feb. 19, 2020
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6sw9
Q-score: 0.337

Coureux PD, Lazennec-Schurdevin C, Bourcier S, Mechulam Y, Schmitt E

Commun Biol (2020) 3 pp. 58-58 [ DOI: doi:10.1038/s42003-020-0780-0 Pubmed: 32029867 ]

Sample:

30s ribosomal protein s27e (7 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s4e (28 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Translation initiation factor 1a (13 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Trna (Complex from Escherichia coli)
Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
30s ribosomal protein s3ae (22 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s12 (16 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s17 (13 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
50s ribosomal protein l7ae (13 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
16s ribosomal rna (487 kDa, RNA from Pyrococcus abyssi GE5)
Initiator met-trna fmet from e. coli (a1u72 variant) (24 kDa, RNA from Escherichia coli)
30s ribosomal protein s19 (15 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Translation initiation factor 2 subunit gamma (45 kDa, Protein from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2))
Methionine (149 Da, Ligand)
30s ribosomal protein s28e (8 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Zn-ribbon rna-binding protein involved in translation (7 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s27ae (5 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s9 (15 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Water (18 Da, Ligand)
30s ribosomal protein s11 (14 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Archaeal translation initiation complex devoid of aif1 - ic2a state (1 MDa, Complex)
Mrna (Complex from Pyrococcus abyssi GE5)
Ribosome (Complex from Pyrococcus abyssi GE5)
30s ribosomal protein s8e (14 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Translation initiation factor 2 subunits alpha, beta and gamma (Complex from Saccharolobus solfataricus P2)
30s ribosomal protein s13 (16 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Translation initiation factor 2 subunit beta (14 kDa, Protein from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2))
30s ribosomal protein s19e (17 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s15 (18 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s7 (24 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s24e (11 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Magnesium ion (24 Da, Ligand)
Mrna (6 kDa, RNA from Pyrococcus abyssi GE5)
30s ribosomal protein s6e (14 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s17e (8 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s2 (23 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
Zinc ion (65 Da, Ligand)
30s ribosomal protein s4 (21 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s10 (11 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s5 (26 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
50s ribosomal protein l41e (4 kDa, Protein from Pyrococcus abyssi GE5)
Translation initiation factor 1a (Complex from Pyrococcus abyssi GE5)
Translation initiation factor 2 subunit alpha (28 kDa, Protein from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2))
30s ribosomal protein s3 (23 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s8 (14 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))
30s ribosomal protein s14 type z (6 kDa, Protein from Pyrococcus abyssi (strain GE5 / Orsay))

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EMD-9702

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Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii)

Release date: May 29, 2019
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6ip6
Q-score: 0.184

Yokoyama T, Machida K, Iwasaki W, Shigeta T, Nishimoto M, Takahashi M, Sakamoto A, Yonemochi M, Harada Y, Shigematsu H, Shirouzu M, Tadakuma H, Imataka H, Ito T

Mol Cell (2019) 74 pp. 1205-1214.e8 [ DOI: doi:10.1016/j.molcel.2019.04.022 Pubmed: 31080011 ]

Sample:

Human 80s ribosome (Complex from Homo sapiens)
40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l37 (11 kDa, Protein from Homo sapiens)
40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
60s ribosomal protein l17 (21 kDa, Protein from Homo sapiens)
Hcv-ires rna (93 kDa, RNA from Homo sapiens)
Nascent peptide (1 kDa, Protein from Homo sapiens)
60s ribosomal protein l15 (24 kDa, Protein from Homo sapiens)
40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
60s ribosomal protein l13a (23 kDa, Protein from Homo sapiens)
5.8s ribosomal rna (50 kDa, RNA from Homo sapiens)
40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
60s ribosomal protein l18 (21 kDa, Protein from Homo sapiens)
60s ribosomal protein l10-like (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l21 (18 kDa, Protein from Homo sapiens)
40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
60s ribosomal protein l35 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
60s ribosomal protein l35a (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
60s ribosomal protein l9 (21 kDa, Protein from Homo sapiens)
P-site trna (24 kDa, RNA from Homo sapiens)
40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
60s ribosomal protein l23a (17 kDa, Protein from Homo sapiens)
40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
60s ribosomal protein l27 (15 kDa, Protein from Homo sapiens)
60s ribosomal protein l11 (20 kDa, Protein from Homo sapiens)
60s ribosomal protein l34 (13 kDa, Protein from Homo sapiens)
60s ribosomal protein l14 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l7a (30 kDa, Protein from Homo sapiens)
18s ribosomal rna (602 kDa, RNA from Homo sapiens)
5s ribosomal rna (38 kDa, RNA from Homo sapiens)
60s ribosomal protein l13 (24 kDa, Protein from Homo sapiens)
60s ribosomal protein l32 (15 kDa, Protein from Homo sapiens)
60s ribosomal protein l37a (10 kDa, Protein from Homo sapiens)
60s ribosomal protein l23 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
60s ribosomal protein l39 (6 kDa, Protein from Homo sapiens)
40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
60s ribosomal protein l36 (12 kDa, Protein from Homo sapiens)
40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l24 (17 kDa, Protein from Homo sapiens)
60s ribosomal protein l36a (12 kDa, Protein from Homo sapiens)
60s ribosomal protein l19 (23 kDa, Protein from Homo sapiens)
60s ribosomal protein l5 (34 kDa, Protein from Homo sapiens)
60s ribosomal protein l27a (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l30 (12 kDa, Protein from Homo sapiens)
60s ribosomal protein l6 (32 kDa, Protein from Homo sapiens)
60s ribosomal protein l4 (47 kDa, Protein from Homo sapiens)
40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
60s ribosomal protein l31 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l22 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l7 (29 kDa, Protein from Homo sapiens)
40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
60s ribosomal protein l29 (17 kDa, Protein from Homo sapiens)
60s ribosomal protein l3 (46 kDa, Protein from Homo sapiens)
60s ribosomal protein l28 (15 kDa, Protein from Homo sapiens)
60s ribosomal protein l38 (8 kDa, Protein from Homo sapiens)
Mrna (1 kDa, RNA from Homo sapiens)
Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
60s ribosomal protein l8 (28 kDa, Protein from Homo sapiens)
60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Homo sapiens)
60s ribosomal protein l18a (20 kDa, Protein from Homo sapiens)
40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
60s ribosomal protein l26 (17 kDa, Protein from Homo sapiens)
28s ribosomal rna (1 MDa, RNA from Homo sapiens)

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EMD-3844

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80S from Trypanosoma cruzi

Release date: Nov. 15, 2017
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 5opt
Q-score: 0.284

Brito Querido J, Mancera-Martinez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y

Structure (2017) 25 pp. 1785-1794.e3 [ DOI: doi:10.1016/j.str.2017.09.014 Pubmed: 29107485 ]

Sample:

40s ribosomal protein s9, putative (22 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s14, putative (15 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s11, putative (20 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s10, putative (18 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s2, putative (28 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s30 (7 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s24 (15 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s12 (15 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
Ribosomal protein s19, putative (18 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s17, putative (22 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s13, putative (17 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s3, putative (24 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
Ribosomal protein s29, putative (6 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s6 (28 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s18, putative (17 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s8 (25 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s3a-2 (29 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
Rna-binding protein, putative (27 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s33, putative (12 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
Ubiquitin/ribosomal protein s27a, putative (16 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s16, putative (16 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s15a, putative (14 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
Ribosomal protein s7, putative (24 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
Activated protein kinase c receptor, putative (35 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s4 (30 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s21, putative (26 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
18s rrna (746 kDa, RNA from Trypanosoma cruzi)
40s ribosomal protein s27, putative (9 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
Ribosomal protein s25, putative (12 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s15, putative (17 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
Ribosomal protein s20, putative (13 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s5, putative (21 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
80s ribosome from trypanosoma cruzi (Complex from Trypanosoma cruzi)
40s ribosomal protein s23, putative (15 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein s26 (12 kDa, Protein from Trypanosoma cruzi (strain CL Brener))
40s ribosomal protein sa (27 kDa, Protein from Trypanosoma cruzi (strain CL Brener))

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