SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 034_32
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7uow
Q-score: 0.268
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Bajpai P, Raju DR, Edara VV, Davis-Gardner ME, Linderman S, Dixit K, Sharma P, Mantus G, Cheedarla N, Verkerke HP, Frank F, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Sharma A, Murali-Krishna K, Chandele A, Ortlund EA
Structure (2023) 31 pp. 801-811.e5 [ Pubmed: 37167972 DOI: doi:10.1016/j.str.2023.04.010 ]
- Sars-cov2 spike trimer in complex with monoclonal antibody (Complex)
- Monoclonal antibody 034_32 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Mab 034-32 heavy chain, mab 034-32 light chain (Complex from Homo sapiens)
- Monoclonal antibody 034_32 heavy chain (48 kDa, Protein from Homo sapiens)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-COV-2 Spike_GSAS_6P bound with three R1-32 Fabs
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 7ye9
Q-score: 0.17
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X
Nat Microbiol (2022) 7 pp. 1635-1649 [ Pubmed: 36151403 DOI: doi:10.1038/s41564-022-01235-4 ]
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Fab (Complex)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike_gsas_6p bound with three r1-32 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike_gsas_6p (Complex from Homo sapiens)
SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7yeg
Q-score: 0.149
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X
Nat Microbiol (2022) 7 pp. 1635-1649 [ Pubmed: 36151403 DOI: doi:10.1038/s41564-022-01235-4 ]
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ace2 (Complex from Homo sapiens)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Fabs (Complex)
- Zinc ion (65 Da, Ligand)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike_gsas_6p (Complex from Homo sapiens)
- Sars-cov-2 spike_gsas_6p bound with three r1-32 fabs and three ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21F2
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 7u0p
Q-score: 0.366
Kumar S, Patel A, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Davis-Gardner ME, Edara VV, Linderman S, Nayak K, Dixit K, Sharma P, Bajpai P, Singh V, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Mantus G, Goel PK, Rahi M, Davis CW, Wrammert J, Godbole S, Henry AR, Douek DC, Suthar MS, Ahmed R, Ortlund E, Sharma A, Murali-Krishna K, Chandele A
Sci Adv (2022) 8 pp. eadd2032-eadd2032 [ Pubmed: 36197988 DOI: doi:10.1126/sciadv.add2032 ]
- Sars-cov2 spike trimer in complex with monoclonal antibody (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Mab 002_s21f2 light chain (23 kDa, Protein from Homo sapiens)
- Mab 002-s21f2 (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Mab 002-s21f2 heavy chain (49 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7upl
Q-score: 0.359
Kumar S, Patel A, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Davis-Gardner ME, Edara VV, Linderman S, Nayak K, Dixit K, Sharma P, Bajpai P, Singh V, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Mantus G, Goel PK, Rahi M, Davis CW, Wrammert J, Godbole S, Henry AR, Douek DC, Suthar MS, Ahmed R, Ortlund E, Sharma A, Murali-Krishna K, Chandele A
Sci Adv (2022) 8 pp. eadd2032-eadd2032 [ Pubmed: 36197988 DOI: doi:10.1126/sciadv.add2032 ]
- Sars-cov2 spike trimer in complex with monoclonal antibody (Complex)
- Mab 002-s21f2 (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Mab 002-s21f2 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mab 002-s21f2 heavy chain (49 kDa, Protein from Homo sapiens)
Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants
Resolution: 2.39 Å
EM Method: Single-particle
Fitted PDBs: 7tpr
Q-score: 0.407
Hong J, Kwon HJ, Cachau R, Chen CZ, Dandey VP, Martin N, Esposito D, Ortega-Rodriguez U, Xu M, Borgnia MJ, Xie H, Ho M
bioRxiv (2021) [ DOI: doi:10.1101/2021.10.27.465996 Pubmed: 34751270 ]
- Spike glycoprotein (126 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Camel nanobody 8a2 (Complex from Camelus dromedarius)
- Ternary complex of sars-cov-2 spike protein ectodomain (wuhan strain) and camel nanobodies 7a3 and 8a2. (17 kDa, Complex)
- Nanobody 8a2 (13 kDa, Protein from Camelus dromedarius)
- Camel nanobody 7a3 (Complex from Camelus dromedarius)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Nanobody 7a3 (13 kDa, Protein from Camelus dromedarius)