Locally refined region of SARS-CoV-2 spike in complex with antibodies 9G11 and 3E2.
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 9lae
Q-score: 0.522
Jiang W, Jiang Y, Sun H, Deng T, Yu K, Fang Q, Ge H, Lan M, Lin Y, Fang Z, Zhang Y, Zhou L, Li T, Yu H, Zheng Q, Li S, Xia N, Gu Y
Emerg Microbes Infect (2024) 13 pp. 2406300- [ DOI: doi:10.1038/s41467-023-39265-z Pubmed: 39470577 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with antibodies 9g11 and 3e2 (Complex)
- Light chain of 9g11 (11 kDa, Protein from Mus musculus)
- Heavy chain of 3e2 (13 kDa, Protein from Mus musculus)
- The fab of 3e2 (Complex from Mus musculus)
- Heavy chain of 9g11 (13 kDa, Protein from Mus musculus)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of 3e2 (11 kDa, Protein from Mus musculus)
- The fab of 9g11 (Complex from Mus musculus)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Structure of SARS-CoV-2 Spike in complex with antibodies 3E2, 9G11 and 13H7.
Structure of SARS-CoV-2 Spike in complex with antibodies 3E2, 9G11 and 13H7 (C1)
Jiang W, Jiang Y, Sun H, Deng T, Yu K, Fang Q, Ge H, Lan M, Lin Y, Fang Z, Zhang Y, Zhou L, Li T, Yu H, Zheng Q, Li S, Xia N, Gu Y
Emerg Microbes Infect (2024) 13 pp. 2406300-2406300 [ DOI: doi:10.1080/22221751.2024.2406300 Pubmed: 39470577 ]
- The fab of 13h7 (Complex from Mus)
- Sars-cov-2 spike (Complex from Homo sapiens)
- The fab of 9g11 (Complex from Mus)
- The fab of 3e2 (Complex)
- Sars-cov-2 spike in complex with 3e2, 9g11 and 13h7 fab (Complex)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8via
Q-score: 0.302
Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, Gonzalez-Dominguez I, Edgar JE, Bournazos S, Sun W, Carreno JM, Simon V, Ellebedy AH, Bajic G, Krammer F
Cell Rep (2024) 43 pp. 114922-114922 [ DOI: doi:10.1016/j.celrep.2024.114922 Pubmed: 39504245 ]
- Spike protein s1 (74 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pvi.v5-4 light chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with pvi.v5-4 fab (500 MDa, Complex from Homo sapiens)
- Pvi.v5-4 heavy chain (25 kDa, Protein from Homo sapiens)
- Spike protein s2 (62 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Hannula L, Kuivanen S, Lasham J, Kant R, Kareinen L, Bogacheva M, Strandin T, Sironen T, Hepojoki J, Sharma V, Saviranta P, Kipar A, Vapalahti O, Huiskonen JT, Rissanen I
Microbiol Spectr (2024) 12 pp. e0419922-e0419922 [ DOI: doi:10.1128/spectrum.04199-22 Pubmed: 38363137 ]
CryoEM reconstruction of SARS-CoV-2 Spike in complex with nanobody tri-TMH (closed conformation)
Hannula L, Kuivanen S, Lasham J, Kant R, Kareinen L, Bogacheva M, Strandin T, Sironen T, Hepojoki J, Sharma V, Saviranta P, Kipar A, Vapalahti O, Huiskonen JT, Rissanen I
Microbiol Spectr (2024) 12 pp. e0419922-e0419922 [ DOI: doi:10.1128/spectrum.04199-22 Pubmed: 38363137 ]
Cryo-EM structure of SARS-CoV-2 spike in complex with VHH14
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7xy3
Q-score: 0.278
Wang K, Cao D, Liu L, Fan X, Wang H, Zhang X, Yang P
To Be Published
- Vhh14 (17 kDa, Protein from Camelus bactrianus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vhh14 (Complex from Camelus bactrianus)
- Sars-cov-2 spike in complex with vhh14 (Complex)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 spike in complex with VHH21
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7xy4
Q-score: 0.43
Wang K, Cao D, Liu L, Fan X, Wang H, Zhang X, Yang P
To Be Published
- Vhh21 (Complex from Camelus bactrianus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vhh21 (16 kDa, Protein from Camelus bactrianus)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with vhh21 (Complex)
SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7y0n
Q-score: 0.333
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- R15-f7 (Complex)
- Complex of sars-cov-2 spike in complex with r15-f7 and p14-f18-35 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of r15-f7 (11 kDa, Protein from Homo sapiens)
- P14 (Complex from Homo sapiens)
- Spike glycoprotein (127 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- P14 nanobody (13 kDa, Protein from Vicugna pacos)
- Heavy chain of r15-f7 (12 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike (Complex from Vicugna pacos)
Interface of SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7y0o
Q-score: 0.3
To Be Published
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- P14 nanobody (13 kDa, Protein from Vicugna pacos)
- Complex of sars-cov-2 spike in complex with r15-f7 and p14-f18-35 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of r15 (11 kDa, Protein from Homo sapiens)
- P14 (Complex)
- Heavy chain of r15 (12 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike (Complex from Homo sapiens)
- R15 (Complex from Vicugna pacos)
- Water (18 Da, Ligand)