Cryo-EM structure of SARS-CoV-2 spike in complex with VHH14
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7xy3
Q-score: 0.278
Wang K, Cao D, Liu L, Fan X, Wang H, Zhang X, Yang P
To Be Published
- Vhh14 (17 kDa, Protein from Camelus bactrianus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vhh14 (Complex from Camelus bactrianus)
- Sars-cov-2 spike in complex with vhh14 (Complex)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 spike in complex with VHH21
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7xy4
Q-score: 0.43
Wang K, Cao D, Liu L, Fan X, Wang H, Zhang X, Yang P
To Be Published
- Vhh21 (Complex from Camelus bactrianus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vhh21 (16 kDa, Protein from Camelus bactrianus)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with vhh21 (Complex)
SARS-CoV-2 spike in complex with AHB2-2GS-SB175
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uhc
Q-score: 0.465
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Multivalent miniprotein inhibitor ahb2-2gs-sb175 (17 kDa, Protein from synthetic construct)
- Sars-cov-2 spike in complex with multivalent minibinder ahb2-2gs-sb175 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hexapro spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor ahb2-2gs-sb175 (Complex from Synthetic construct)
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7fjn
Q-score: 0.27
Liang Q, Wang Y, Zhang S, Sun J, Sun W, Li J, Liu Y, Li M, Cheng L, Jiang Y, Wang R, Zhang R, Yang Z, Ren Y, Chen P, Gao P, Yan H, Zhang Z, Zhang Q, Shi X, Wang J, Liu W, Wang X, Ying B, Zhao J, Qi H, Zhang L
iScience (2022) 25 pp. 104043-104043 [ Pubmed: 35291264 DOI: doi:10.1016/j.isci.2022.104043 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S protein of south african (b.1.351) sars-cov-2 (Complex from Homo sapiens)
- T6 light chain (12 kDa, Protein from Homo sapiens)
- T6 heavy chain (12 kDa, Protein from Homo sapiens)
- T6 fab (Complex)
- Spike glycoprotein,envelope glycoprotein (141 kDa, Protein from Human immunodeficiency virus 1)
- S protein of south african (b.1.351) sars-cov-2 spike in complex with t6 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Spike (2P) in complex with G32R7 Fab (RBD and NTD local reconstruction)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7n64
Q-score: 0.393
Tong P, Gautam A, Windsor I, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Lelis FJN, Habibi S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR
bioRxiv (2021) [ DOI: doi:10.1101/2021.03.10.434840 Pubmed: 33758863 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with g32r7 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- G32r7 fab heavy chain (25 kDa, Protein from Homo sapiens)
- G32r7 fab light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7mm0
Q-score: 0.384
Wang L, Zhou T, Zhang Y, Yang ES, Schramm CA, Shi W, Pegu A, Oloniniyi OK, Henry AR, Darko S, Narpala SR, Hatcher C, Martinez DR, Tsybovsky Y, Phung E, Abiona OM, Antia A, Cale EM, Chang LA, Choe M, Corbett KS, Davis RL, DiPiazza AT, Gordon IJ, Hait SH, Hermanus T, Kgagudi P, Laboune F, Leung K, Liu T, Mason RD, Nazzari AF, Novik L, O'Connell S, O'Dell S, Olia AS, Schmidt SD, Stephens T, Stringham CD, Talana CA, Teng IT, Wagner DA, Widge AT, Zhang B, Roederer M, Ledgerwood JE, Ruckwardt TJ, Gaudinski MR, Moore PL, Doria-Rose NA, Baric RS, Graham BS, McDermott AB, Douek DC, Kwong PD, Mascola JR, Sullivan NJ, Misasi J
Science (2021) 373 [ DOI: doi:10.1126/science.abh1766 Pubmed: 34210892 ]
- B1-182.1 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (132 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- B1-182.1 fab light chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with neutralizing antibody b1-182.1 (539 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
CryoEM structure of neutralizing nanobody Nb30 in complex with SARS-CoV2 spike
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 7my2
Q-score: 0.467
Xu J, Xu K, Jung S, Conte A, Lieberman J, Muecksch F, Lorenzi JCC, Park S, Schmidt F, Wang Z, Huang Y, Luo Y, Nair MS, Wang P, Schulz JE, Tessarollo L, Bylund T, Chuang GY, Olia AS, Stephens T, Teng IT, Tsybovsky Y, Zhou T, Munster V, Ho DD, Hatziioannou T, Bieniasz PD, Nussenzweig MC, Kwong PD, Casellas R
Nature (2021) 595 pp. 278-282 [ DOI: doi:10.1038/s41586-021-03676-z Pubmed: 34098567 ]
- Nanobody nb30 (14 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov2 spike in complex with nanobody nb30 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Nanobody nb30 (Complex from Mus musculus)
- Sars-cov2 spike (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
CryoEM structure of neutralizing nanobody Nb12 in complex with SARS-CoV2 spike
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7my3
Q-score: 0.491
Xu J, Xu K, Jung S, Conte A, Lieberman J, Muecksch F, Lorenzi JCC, Park S, Schmidt F, Wang Z, Huang Y, Luo Y, Nair MS, Wang P, Schulz JE, Tessarollo L, Bylund T, Chuang GY, Olia AS, Stephens T, Teng IT, Tsybovsky Y, Zhou T, Munster V, Ho DD, Hatziioannou T, Bieniasz PD, Nussenzweig MC, Kwong PD, Casellas R
Nature (2021) 595 pp. 278-282 [ DOI: doi:10.1038/s41586-021-03676-z Pubmed: 34098567 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody nb12 (13 kDa, Protein from Mus musculus)
- Nanobody nb12 (Complex from Mus musculus)
- Sars-cov2 spike in complex with nanobody nb12 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov2 spike (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)