Cryo-EM structure of SARS-CoV-2 spike in complex with VHH14
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7xy3
Q-score: 0.278
Wang K, Cao D, Liu L, Fan X, Wang H, Zhang X, Yang P
To Be Published
- Vhh14 (17 kDa, Protein from Camelus bactrianus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vhh14 (Complex from Camelus bactrianus)
- Sars-cov-2 spike in complex with vhh14 (Complex)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
Interface of SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7y0o
Q-score: 0.3
To Be Published
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- P14 nanobody (13 kDa, Protein from Vicugna pacos)
- Complex of sars-cov-2 spike in complex with r15-f7 and p14-f18-35 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of r15 (11 kDa, Protein from Homo sapiens)
- P14 (Complex)
- Heavy chain of r15 (12 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike (Complex from Homo sapiens)
- R15 (Complex from Vicugna pacos)
- Water (18 Da, Ligand)
SARS-CoV-2 Spike in complex with biparatopic nanobody BP10
Pymm P, Redmond SJ, Dolezal O, Mordant F, Lopez E, Cooney JP, Davidson KC, Haycroft ER, Tan CW, Seneviratna R, Grimley SL, Purcell DFJ, Kent SJ, Wheatley AK, Wang LF, Leis A, Glukhova A, Pellegrini M, Chung AW, Subbarao K, Uldrich AP, Tham WH, Godfrey DI, Gherardin NA
iScience (2022) 25 pp. 105259-105259 [ DOI: doi:10.1016/j.isci.2022.105259 Pubmed: 36213007 ]
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with biparatopic nanobody bp10 (1 MDa, Complex)
- Bp10 biparatopic nanobody (Complex from Vicugna pacos)
- Bp10 biparatopic nanobody (Protein from Vicugna pacos)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with multivalent miniprotein inhibitor FUS31-G10 (2RBDs open)
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus31-g10 (Complex from Synthetic construct)
- Sars-cov-2 spike in complex with multivalent miniprotein inhibitor fus31-g10 (2rbds open) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus31-g10 (Protein from Synthetic construct)
SARS-CoV-2 spike in complex with multivalent miniprotein inhibitor FUS31-G10 (3RBDs open)
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- Multivalent miniprotein inhibitor fus31-g10 (Complex from Synthetic construct)
- Sars-cov-2 spike in complex with multivalent miniprotein inhibitor fus31-g10 (3rbds open) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor fus31-g10 (Protein from Synthetic construct)
Structure of SARS-CoV-2 spike in complex with polyclonal Fab12
Bangaru S, Antanasijevic A, Kose N, Sewall LM, Jackson AM, Suryadevara N, Zhan X, Torres JL, Copps J, de la Pena AT, Crowe Jr JE, Ward AB
Sci Adv (2022) 8 pp. eabn2911-eabn2911 [ Pubmed: 35507649 DOI: doi:10.1126/sciadv.abn2911 ]
Structure of SARS-CoV-2 spike in complex with polyclonal Fab13
Bangaru S, Antanasijevic A, Kose N, Sewall LM, Jackson AM, Suryadevara N, Zhan X, Torres JL, Copps J, de la Pena AT, Crowe Jr JE, Ward AB
Sci Adv (2022) 8 pp. eabn2911-eabn2911 [ Pubmed: 35507649 DOI: doi:10.1126/sciadv.abn2911 ]
Structure of SARS-CoV-2 spike in complex with polyclonal Fab14
Bangaru S, Antanasijevic A, Kose N, Sewall LM, Jackson AM, Suryadevara N, Zhan X, Torres JL, Copps J, de la Pena AT, Crowe Jr JE, Ward AB
Sci Adv (2022) 8 pp. eabn2911-eabn2911 [ Pubmed: 35507649 DOI: doi:10.1126/sciadv.abn2911 ]
Structure of SARS-CoV-2 spike in complex with polyclonal Fab15
Bangaru S, Antanasijevic A, Kose N, Sewall LM, Jackson AM, Suryadevara N, Zhan X, Torres JL, Copps J, de la Pena AT, Crowe Jr JE, Ward AB
Sci Adv (2022) 8 pp. eabn2911-eabn2911 [ Pubmed: 35507649 DOI: doi:10.1126/sciadv.abn2911 ]
Resolution: 4.18 Å
EM Method: Single-particle
Fitted PDBs: 7rq6
Q-score: 0.33
Beaudoin-Bussieres G, Chen Y, Ullah I, Prevost J, Tolbert WD, Symmes K, Ding S, Benlarbi M, Gong SY, Tauzin A, Gasser R, Chatterjee D, Vezina D, Goyette G, Richard J, Zhou F, Stamatatos L, McGuire AT, Charest H, Roger M, Pozharski E, Kumar P, Mothes W, Uchil PD, Pazgier M, Finzi A
Cell Rep (2022) 38 pp. 110368-110368 [ DOI: doi:10.1016/j.celrep.2022.110368 Pubmed: 35123652 ]
- Cv3-13 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 spike in complex with non-neutralizing, ntd-directed human antibody cv3-13 (670 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cv3-13 fab heavy chain (24 kDa, Protein from Homo sapiens)