Cryo-EM Structure of Human Serine Hydroxymethyltransferase, isoform 2 (SHMT2)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8qi7
Q-score: 0.598
Rutkiewicz M, Tran LH, Ruszkowski M
To Be Published
- Water (18 Da, Ligand)
- Shmt2 in the form of plp internal aldimine (Complex from Homo sapiens)
- Serine hydroxymethyltransferase, mitochondrial (52 kDa, Protein from Homo sapiens)
Cryo-EM structure of the Human SHMT1-RNA complex
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8a11
Q-score: 0.395
Spizzichino S, Di Fonzo F, Marabelli C, Tramonti A, Chaves-Sanjuan A, Parroni A, Boumis G, Liberati FR, Paone A, Montemiglio LC, Ardini M, Jakobi AJ, Bharadwaj A, Swuec P, Tartaglia GG, Paiardini A, Contestabile R, Mai A, Rotili D, Fiorentino F, Macone A, Giorgi A, Tria G, Rinaldo S, Bolognesi M, Giardina G, Cutruzzola F
Mol Cell (2024) [ DOI: doi:10.1016/j.molcel.2024.06.016 Pubmed: 38996576 ]
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Serine hydroxymethyltransferase, cytosolic (53 kDa, Protein from Homo sapiens)
- Human shmt1 in complex with rna (shmt2 5' utr 1-50) (53 MDa, Complex from Homo sapiens)
Cryo-EM structure of the BRISC complex bound to SHMT2
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6h3c
Q-score: 0.278
Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andres-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guerillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thoma NH
Mol Cell (2019) 75 pp. 483-497.e9 [ DOI: doi:10.1016/j.molcel.2019.06.002 Pubmed: 31253574 ]
- Shmt2 alpha (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Brisc and brca1-a complex member 1 (39 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Brisc complex (Complex from Homo sapiens)
- Serine hydroxymethyltransferase, mitochondrial (56 kDa, Protein from Homo sapiens)
- Brisc and brca1-a complex member 2 (45 kDa, Protein from Homo sapiens)
- Brisc complex subunit abraxas 2 (49 kDa, Protein from Homo sapiens)
- Lys-63-specific deubiquitinase brcc36 (38 kDa, Protein from Homo sapiens)
- Brisc complex bound to shmt2 alpha (438 kDa, Complex)
Cryo-EM structure of the Human BRISC-SHMT2 complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6r8f
Q-score: 0.451
Walden M, Tian L, Ross RL, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, George R, Ault JR, El Oualid F, Pawlowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA, Zeqiraj E
Nature (2019) 570 pp. 194-199 [ Pubmed: 31142841 DOI: doi:10.1038/s41586-019-1232-1 ]
- Merit40 (brisc and brca1-a complex member 1) (Complex from Homo sapiens)
- Brisc-shmt2 (388 MDa, Complex)
- Brisc complex subunit abraxas 2 (31 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Lys-63-specific deubiquitinase brcc36 (36 kDa, Protein from Homo sapiens)
- Serine hydroxymethyltransferase, mitochondrial (56 kDa, Protein from Homo sapiens)
- Serine hydroxymethyltransferase, mitochondrial (Complex from Homo sapiens)
- Brisc and brca1-a complex member 2,brcc45 (bre, brisc and brca1-a complex member 2) (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of the Human BRISC-SHMT2 complex, C2 reconstruction
Walden M, Tian L, Ross RL, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, George R, Ault JR, El Oualid F, Pawlowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA, Zeqiraj E
Nature (2019) 570 pp. 194-199 [ Pubmed: 31142841 DOI: doi:10.1038/s41586-019-1232-1 ]
- Abraxas2 (Protein from Homo sapiens)
- Brcc45 (bre) (Protein from Homo sapiens)
- Brcc36 (Protein from Homo sapiens)
- Merit40 (babam1) (Protein from Homo sapiens)
- Shmt2 (Protein from Homo sapiens)
- Brisc-shmt2 (388 MDa, Complex from Homo sapiens)