Human sodium-dependent vitamin C transporter 1 in an apo inward-open state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8jez
Q-score: 0.616
Kobayashi TA, Shimada H, Sano FK, Itoh Y, Enoki S, Okada Y, Kusakizako T, Nureki O
Nat Commun (2024) 15 pp. 5569-5569 [ Pubmed: 38956111 DOI: doi:10.1038/s41467-024-49899-2 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Palmitic acid (256 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Human svct1 dimer in an apo inward-open state (Complex from Homo sapiens)
- Solute carrier family 23 member 1 (64 kDa, Protein from Homo sapiens)
Human sodium-dependent vitamin C transporter 1 bound to L-ascorbic acid in an inward-open state
Kobayashi TA, Shimada H, Sano FK, Itoh Y, Enoki S, Okada Y, Kusakizako T, Nureki O
Nat Commun (2024) 15 pp. 5569-5569 [ Pubmed: 38956111 DOI: doi:10.1038/s41467-024-49899-2 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Human svct1 dimer in a substrate-bound inward-open state (Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Ascorbic acid (176 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Solute carrier family 23 member 1 (64 kDa, Protein from Homo sapiens)
Human sodium-dependent vitamin C transporter 1 in an intermediate state
Kobayashi TA, Shimada H, Sano FK, Itoh Y, Enoki S, Okada Y, Kusakizako T, Nureki O
Nat Commun (2024) 15 pp. 5569-5569 [ Pubmed: 38956111 DOI: doi:10.1038/s41467-024-49899-2 ]
Human sodium-dependent vitamin C transporter 1 in an apo occluded state
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8jf1
Q-score: 0.595
Kobayashi TA, Shimada H, Sano FK, Itoh Y, Enoki S, Okada Y, Kusakizako T, Nureki O
Nat Commun (2024) 15 pp. 5569-5569 [ Pubmed: 38956111 DOI: doi:10.1038/s41467-024-49899-2 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Human svct1 dimer in an apo occluded state (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Solute carrier family 23 member 1 (64 kDa, Protein from Homo sapiens)
Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ytw
Q-score: 0.507
Wang M, He J, Li S, Cai Q, Zhang K, She J
Nat Commun (2023) 14 pp. 1361-1361 [ Pubmed: 36914666 DOI: doi:10.1038/s41467-023-37037-3 ]
- Water (18 Da, Ligand)
- Svct1 (Complex from Mus musculus)
- Solute carrier family 23 member 1 (65 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Ascorbic acid (176 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7yty
Q-score: 0.447
Wang M, He J, Li S, Cai Q, Zhang K, She J
Nat Commun (2023) 14 pp. 1361-1361 [ Pubmed: 36914666 DOI: doi:10.1038/s41467-023-37037-3 ]
- Svct1 (Complex from Mus musculus)
- Solute carrier family 23 member 1 (65 kDa, Protein from Mus musculus)