Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8rql
Q-score: 0.48
Peri L, Matzov D, Huxley DR, Rainish A, Fierro F, Sapir L, Pfeiffer T, Waterloo L, Hubner H, Peleg Y, Gmeiner P, McCormick PJ, Weikert D, Niv MY, Shalev-Benami M
Nat Commun (2024) 15 pp. 9991-9991 [ DOI: doi:10.1038/s41467-024-54157-6 Pubmed: 39557861 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(t) subunit alpha-3 (25 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Human taste receptor type 2 member 14 in complex with g-proteins (Complex from Homo sapiens)
- Human taste receptor type 2 member 14 in complex with g-proteins (118 MDa, Complex)
- 2-[[3-(trifluoromethyl)phenyl]amino] benzoic acid (281 Da, Ligand)
- Scfv16 (antibody) (Complex from Mus musculoides)
- Taste receptor type 2 member 14 (36 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculoides)
Structure of Niacin-GPR109A-G protein complex
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8iy9
Q-score: 0.494
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (antibody fragment) (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Structure of gpr109a-g protein in complex with niacin (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of MK6892-GPR109A-G-protein complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8iyh
Q-score: 0.498
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Scfv16 antibody (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Structure of mk6892-gpr109a-g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of GSK256073-GPR109A-G-protein complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8iyw
Q-score: 0.469
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- 8-chloranyl-3-pentyl-7h-purine-2,6-dione (256 Da, Ligand)
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Structure of gsk256073-gpr109a-g-protein complex (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of Acipimox-GPR109A-G protein complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8jer
Q-score: 0.468
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)
- Acipimox-gpr109a-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of MMF-GPR109A-G protein complex
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8jhn
Q-score: 0.441
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 (antibody) (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Gpr109a-g protein in complex with mmf (Complex from Homo sapiens)
- Hydrocarboxylic acid receptor 2/gpr109a (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (antibody) (Complex from Mus musculus)
- G protein subunit alpha o1,guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s) /g(t) subunit beta-1 (Complex from Homo sapiens)
- Monomethyl fumarate (130 Da, Ligand)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8feg
Q-score: 0.471
Muratspahic E, Deibler K, Han J, Tomasevic N, Jadhav KB, Olive-Marti AL, Hochrainer N, Hellinger R, Koehbach J, Fay JF, Rahman MH, Hegazy L, Craven TW, Varga BR, Bhardwaj G, Appourchaux K, Majumdar S, Muttenthaler M, Hosseinzadeh P, Craik DJ, Spetea M, Che T, Baker D, Gruber CW
Nat Commun (2023) 14 pp. 8064- [ DOI: doi:10.1016/0006-2952(73)90196-2 Pubmed: 38052802 ]
- Kappa opioid receptor in complex with gi1 heterotrimer and a peptide ligand (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Ace-tyr-ala-dty-thr-thr-cys-thr-dpn-xt9 (1 kDa, Protein from synthetic construct)
- Kappa-type opioid receptor (34 kDa, Protein from Homo sapiens)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)