Structure of a B-state intermediate committed to discard (Bd-I state)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9esh
Q-score: 0.324
Soni K, Horvath A, Dybkov O, Schwan M, Trakansuebkul S, Flemming D, Wild K, Urlaub H, Fischer T, Sinning I
Nat Struct Mol Biol (2025) [ Pubmed: 39833470 DOI: doi:10.1038/s41594-024-01480-7 ]
- U6snrna (31 kDa, RNA from Schizosaccharomyces pombe)
- Pre-mrna-processing protein 45 (62 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf5 (39 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Schizosaccharomyces pombe)
- Uncharacterized protein c20h4.06c (60 kDa, Protein from Schizosaccharomyces pombe)
- U5snrna (38 kDa, RNA from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein-associated protein b (15 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf21 (34 kDa, Protein from Schizosaccharomyces pombe)
- Unk2 (29 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf11 (148 kDa, Protein from Schizosaccharomyces pombe)
- Peptidyl-prolyl cis-trans isomerase ppi1 (16 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf15 (30 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf2 (44 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf7 (21 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf17 (37 kDa, Protein from Schizosaccharomyces pombe)
- Potassium ion (39 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor prp5 (52 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein e (9 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor spp42 (274 kDa, Protein from Schizosaccharomyces pombe)
- Unk1 (1 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf22 (102 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cdc5 (86 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 17 (63 kDa, Protein from Schizosaccharomyces pombe)
- Putative pre-mrna-splicing factor atp-dependent rna helicase c20h4.09 (73 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf14 (17 kDa, Protein from Schizosaccharomyces pombe)
- G-patch domain-containing protein c1486.03 (91 kDa, Protein from Schizosaccharomyces pombe)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein f (8 kDa, Protein from Schizosaccharomyces pombe)
- Zinc ion (65 Da, Ligand)
- Pre-mrna-splicing factor cwf10 (111 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 19 (54 kDa, Protein from Schizosaccharomyces pombe)
- Bd-i complex (Complex from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf3 (92 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna (9 kDa, RNA from Schizosaccharomyces pombe)
- Inositol hexakisphosphate (660 Da, Ligand)
- U2snrna (59 kDa, RNA from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf4 (80 kDa, Protein from Schizosaccharomyces pombe)
Structure of a B-state intermediate committed to discard (Bd-II state)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9esi
Q-score: 0.364
Soni K, Horvath A, Dybkov O, Schwan M, Trakansuebkul S, Flemming D, Wild K, Urlaub H, Fischer T, Sinning I
Nat Struct Mol Biol (2025) [ Pubmed: 39833470 DOI: doi:10.1038/s41594-024-01480-7 ]
- U6snrna (31 kDa, RNA from Schizosaccharomyces pombe)
- Pre-mrna-processing protein 45 (62 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf5 (39 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Schizosaccharomyces pombe)
- Uncharacterized protein c20h4.06c (60 kDa, Protein from Schizosaccharomyces pombe)
- U5snrna (38 kDa, RNA from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein-associated protein b (15 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf21 (34 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf11 (148 kDa, Protein from Schizosaccharomyces pombe)
- Peptidyl-prolyl cis-trans isomerase ppi1 (16 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf15 (30 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf2 (44 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf7 (21 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf17 (37 kDa, Protein from Schizosaccharomyces pombe)
- Potassium ion (39 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor prp5 (52 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein e (9 kDa, Protein from Schizosaccharomyces pombe)
- Unk1 (29 kDa, Protein from Schizosaccharomyces pombe)
- Stress response protein bis1 (43 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor spp42 (274 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf22 (102 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cdc5 (86 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 17 (63 kDa, Protein from Schizosaccharomyces pombe)
- Putative pre-mrna-splicing factor atp-dependent rna helicase c20h4.09 (73 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf14 (17 kDa, Protein from Schizosaccharomyces pombe)
- Unk2 (4 kDa, Protein from Schizosaccharomyces pombe)
- G-patch domain-containing protein c1486.03 (91 kDa, Protein from Schizosaccharomyces pombe)
- Magnesium ion (24 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Schizosaccharomyces pombe)
- Bd-ii complex (Complex from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein f (8 kDa, Protein from Schizosaccharomyces pombe)
- Zinc ion (65 Da, Ligand)
- Pre-mrna-splicing factor cwf10 (111 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Schizosaccharomyces pombe)
- Unk3 (1 kDa, Protein from Schizosaccharomyces pombe)
- Uncharacterized protein c17a2.08c (41 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 19 (54 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf3 (92 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna (9 kDa, RNA from Schizosaccharomyces pombe)
- Protein saf4 (34 kDa, Protein from Schizosaccharomyces pombe)
- U2snrna (59 kDa, RNA from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf4 (80 kDa, Protein from Schizosaccharomyces pombe)
Structure of the human 20S U5 snRNP core
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8q91
Q-score: 0.417
Schneider S, Brandina I, Peter D, Lagad S, Fraudeau A, Portell-Montserrat J, Tholen J, Zhao J, Galej WP
Nat Struct Mol Biol (2024) 31 pp. 752-756 [ Pubmed: 38467877 DOI: doi:10.1038/s41594-024-01250-5 ]
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Probable atp-dependent rna helicase ddx23 (95 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Cd2 antigen cytoplasmic tail-binding protein 2 (37 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- 20s u5 snrnp complex purified from hek293f cell line (1 MDa, Complex from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
Structure of the human 20S U5 snRNP
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8rc0
Q-score: 0.309
Schneider S, Brandina I, Peter D, Lagad S, Fraudeau A, Portell-Montserrat J, Tholen J, Zhao J, Galej WP
Nat Struct Mol Biol (2024) 31 pp. 752-756 [ Pubmed: 38467877 DOI: doi:10.1038/s41594-024-01250-5 ]
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Probable atp-dependent rna helicase ddx23 (95 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 6 (107 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Cd2 antigen cytoplasmic tail-binding protein 2 (37 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- 20s u5 snrnp complex purified from hek293f cell line (1 MDa, Complex from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
Saccharomyces cerevisiae spliceosomal E complex (UBC4)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6n7p
Q-score: 0.352
Li X, Liu S, Zhang L, Issaian A, Hill RC, Espinosa S, Shi S, Cui Y, Kappel K, Das R, Hansen KC, Zhou ZH, Zhao R
Nature (2019) 573 pp. 375-380 [ Pubmed: 31485080 DOI: doi:10.1038/s41586-019-1523-6 ]
- U1 small nuclear ribonucleoprotein 70 kda homolog (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein component prp42 (65 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Nuclear cap-binding protein complex subunit 1 (100 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein a (40 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Pre-mrna-processing factor 39 (74 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Pre-mrna-processing protein prp40 (69 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein c (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein component snu71,u1 small nuclear ribonucleoprotein component snu71,snu71 (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 56 kda u1 small nuclear ribonucleoprotein component (56 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Protein luc7 (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Nuclear cap-binding protein subunit 2 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Protein nam8 (57 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- U1 snrna (182 kDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubc4 pre-mrna (81 kDa, RNA from Saccharomyces cerevisiae S288C)
- Saccharomyces cerevisiae spliceosomal e complex (ebc4) (Complex from Saccharomyces cerevisiae)
Saccharomyces cerevisiae spliceosomal E complex (ACT1)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6n7r
Q-score: 0.427
Li X, Liu S, Zhang L, Issaian A, Hill RC, Espinosa S, Shi S, Cui Y, Kappel K, Das R, Hansen KC, Zhou ZH, Zhao R
Nature (2019) 573 pp. 375-380 [ Pubmed: 31485080 DOI: doi:10.1038/s41586-019-1523-6 ]
- U1 snrna (182 kDa, RNA from Saccharomyces cerevisiae)
- U1 small nuclear ribonucleoprotein 70 kda homolog (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein component prp42 (65 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein a (40 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Pre-mrna-processing factor 39 (74 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Saccharomyces cerevisiae spliceosomal e complex (act1) (Complex from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Act1 pre-mrna (70 kDa, RNA from Saccharomyces cerevisiae S288C)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein c (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 56 kda u1 small nuclear ribonucleoprotein component (56 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Protein luc7 (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Protein nam8 (57 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein component snu71,u1 small nuclear ribonucleoprotein component snu71,snu71 (9 kDa, Protein from Saccharomyces cerevisiae S288C)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)