Structure of a B-state intermediate committed to discard (Bd-I state)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9esh
Q-score: 0.324
Soni K, Horvath A, Dybkov O, Schwan M, Trakansuebkul S, Flemming D, Wild K, Urlaub H, Fischer T, Sinning I
Nat Struct Mol Biol (2025) [ Pubmed: 39833470 DOI: doi:10.1038/s41594-024-01480-7 ]
- U6snrna (31 kDa, RNA from Schizosaccharomyces pombe)
- Pre-mrna-processing protein 45 (62 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf5 (39 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Schizosaccharomyces pombe)
- Uncharacterized protein c20h4.06c (60 kDa, Protein from Schizosaccharomyces pombe)
- U5snrna (38 kDa, RNA from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein-associated protein b (15 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf21 (34 kDa, Protein from Schizosaccharomyces pombe)
- Unk2 (29 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf11 (148 kDa, Protein from Schizosaccharomyces pombe)
- Peptidyl-prolyl cis-trans isomerase ppi1 (16 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf15 (30 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf2 (44 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf7 (21 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf17 (37 kDa, Protein from Schizosaccharomyces pombe)
- Potassium ion (39 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor prp5 (52 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein e (9 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor spp42 (274 kDa, Protein from Schizosaccharomyces pombe)
- Unk1 (1 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf22 (102 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cdc5 (86 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 17 (63 kDa, Protein from Schizosaccharomyces pombe)
- Putative pre-mrna-splicing factor atp-dependent rna helicase c20h4.09 (73 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf14 (17 kDa, Protein from Schizosaccharomyces pombe)
- G-patch domain-containing protein c1486.03 (91 kDa, Protein from Schizosaccharomyces pombe)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein f (8 kDa, Protein from Schizosaccharomyces pombe)
- Zinc ion (65 Da, Ligand)
- Pre-mrna-splicing factor cwf10 (111 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 19 (54 kDa, Protein from Schizosaccharomyces pombe)
- Bd-i complex (Complex from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf3 (92 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna (9 kDa, RNA from Schizosaccharomyces pombe)
- Inositol hexakisphosphate (660 Da, Ligand)
- U2snrna (59 kDa, RNA from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf4 (80 kDa, Protein from Schizosaccharomyces pombe)
Structure of a B-state intermediate committed to discard (Bd-II state)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9esi
Q-score: 0.364
Soni K, Horvath A, Dybkov O, Schwan M, Trakansuebkul S, Flemming D, Wild K, Urlaub H, Fischer T, Sinning I
Nat Struct Mol Biol (2025) [ Pubmed: 39833470 DOI: doi:10.1038/s41594-024-01480-7 ]
- U6snrna (31 kDa, RNA from Schizosaccharomyces pombe)
- Pre-mrna-processing protein 45 (62 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf5 (39 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Schizosaccharomyces pombe)
- Uncharacterized protein c20h4.06c (60 kDa, Protein from Schizosaccharomyces pombe)
- U5snrna (38 kDa, RNA from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein-associated protein b (15 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf21 (34 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf11 (148 kDa, Protein from Schizosaccharomyces pombe)
- Peptidyl-prolyl cis-trans isomerase ppi1 (16 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf15 (30 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf2 (44 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf7 (21 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf17 (37 kDa, Protein from Schizosaccharomyces pombe)
- Potassium ion (39 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor prp5 (52 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein e (9 kDa, Protein from Schizosaccharomyces pombe)
- Unk1 (29 kDa, Protein from Schizosaccharomyces pombe)
- Stress response protein bis1 (43 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor spp42 (274 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf22 (102 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cdc5 (86 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 17 (63 kDa, Protein from Schizosaccharomyces pombe)
- Putative pre-mrna-splicing factor atp-dependent rna helicase c20h4.09 (73 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf14 (17 kDa, Protein from Schizosaccharomyces pombe)
- Unk2 (4 kDa, Protein from Schizosaccharomyces pombe)
- G-patch domain-containing protein c1486.03 (91 kDa, Protein from Schizosaccharomyces pombe)
- Magnesium ion (24 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Schizosaccharomyces pombe)
- Bd-ii complex (Complex from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein f (8 kDa, Protein from Schizosaccharomyces pombe)
- Zinc ion (65 Da, Ligand)
- Pre-mrna-splicing factor cwf10 (111 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Schizosaccharomyces pombe)
- Unk3 (1 kDa, Protein from Schizosaccharomyces pombe)
- Uncharacterized protein c17a2.08c (41 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 19 (54 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf3 (92 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna (9 kDa, RNA from Schizosaccharomyces pombe)
- Protein saf4 (34 kDa, Protein from Schizosaccharomyces pombe)
- U2snrna (59 kDa, RNA from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf4 (80 kDa, Protein from Schizosaccharomyces pombe)
Cryo-EM map of the Chlamydomonas C* complex from Cdc5L-Flag dataset
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xi2
Q-score: 0.381
EMBO J (2024) [ Pubmed: 39415054 DOI: doi:10.1038/s44318-024-00274-3 ]
- Rna (173-mer) (55 kDa, RNA from Chlamydomonas reinhardtii)
- Ppiase cyclophilin-type domain-containing protein (61 kDa, Protein from Chlamydomonas reinhardtii)
- Crooked neck protein (96 kDa, Protein from Chlamydomonas reinhardtii)
- U5 snrna (35 kDa, RNA from Chlamydomonas reinhardtii)
- Peptidyl-prolyl cis-trans isomerase (17 kDa, Protein from Chlamydomonas reinhardtii)
- U2 snrna (61 kDa, RNA from Chlamydomonas reinhardtii)
- Intron-binding protein aquarius (201 kDa, Protein from Chlamydomonas reinhardtii)
- Mi domain-containing protein (102 kDa, Protein from Chlamydomonas reinhardtii)
- Cwf21 domain-containing protein (80 kDa, Protein from Chlamydomonas reinhardtii)
- Elongation factor tu, chloroplastic (109 kDa, Protein from Chlamydomonas reinhardtii)
- U6 snrna (32 kDa, RNA from Chlamydomonas reinhardtii)
- Pre-mrna-processing factor 19 (54 kDa, Protein from Chlamydomonas reinhardtii)
- Sm protein f (9 kDa, Protein from Chlamydomonas reinhardtii)
- Rna (5'-r(p*cp*cp*gp*ap*ap*cp*g)-3') (2 kDa, RNA from Chlamydomonas reinhardtii)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Chlamydomonas reinhardtii)
- Mpn domain-containing protein (278 kDa, Protein from Chlamydomonas reinhardtii)
- Small nuclear ribonucleoprotein sm d1 (12 kDa, Protein from Chlamydomonas reinhardtii)
- U5-40k (39 kDa, Protein from Chlamydomonas reinhardtii)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Chlamydomonas reinhardtii)
- Prp17 (63 kDa, Protein from Chlamydomonas reinhardtii)
- Chlamydomonas c* complex (Complex from Chlamydomonas reinhardtii)
- Plrg1 (56 kDa, Protein from Chlamydomonas reinhardtii)
- Syf1 (104 kDa, Protein from Chlamydomonas reinhardtii)
- Rbm22 (44 kDa, Protein from Chlamydomonas reinhardtii)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Chlamydomonas reinhardtii)
- Sm domain-containing protein (27 kDa, Protein from Chlamydomonas reinhardtii)
- Ski-interacting protein skip snw domain-containing protein (73 kDa, Protein from Chlamydomonas reinhardtii)
- Zinc ion (65 Da, Ligand)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Chlamydomonas reinhardtii)
- Cwf15/cwc15 cell cycle control protein (26 kDa, Protein from Chlamydomonas reinhardtii)
- G10 protein (26 kDa, Protein from Chlamydomonas reinhardtii)
- Cdc5l (91 kDa, Protein from Chlamydomonas reinhardtii)
- Pre-mrna-splicing factor spf27 (32 kDa, Protein from Chlamydomonas reinhardtii)
Human spliceosomal PM5 C* complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8c6j
Q-score: 0.353
Dybkov O, Preussner M, El Ayoubi L, Feng VY, Harnisch C, Merz K, Leupold P, Yudichev P, Agafonov DE, Will CL, Girard C, Dienemann C, Urlaub H, Kastner B, Heyd F, Luehrmann R
Sci Adv (2023) 9 pp. eadf1785- [ Pubmed: 36867703 DOI: doi:10.1126/sciadv.adf1785 ]
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Homo sapiens)
- Human spliceosomal c* complex assembled on pm5 pre-mrna (Complex from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Prkr-interacting protein 1 (21 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 17 (65 kDa, Protein from Homo sapiens)
- Nitric oxide synthase-interacting protein (33 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor cwc22 homolog (57 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- Pm5 intron (74 kDa, RNA from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Protein fam50a (40 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase-like 3 (18 kDa, Protein from Homo sapiens)
- Atp-dependent rna helicase dhx8 (139 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Splicing factor cactin (88 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
- U5 snrna (36 kDa, RNA from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Sting er exit protein (25 kDa, Protein from Homo sapiens)
- Probable atp-dependent rna helicase ddx41 (69 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Crooked neck-like protein 1 (83 kDa, Protein from Homo sapiens)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Homo sapiens)
- Rna-binding protein 8a (19 kDa, Protein from Homo sapiens)
- Protein fam32a (13 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Splicing regulator sde2 (49 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Protein mago nashi homolog (17 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Eukaryotic initiation factor 4a-iii (46 kDa, Protein from Homo sapiens)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 19 (55 kDa, Protein from Homo sapiens)
- Intron-binding protein aquarius (171 kDa, Protein from Homo sapiens)
- Pm5 5' exon (78 kDa, RNA from Homo sapiens)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor slu7 (68 kDa, Protein from Homo sapiens)
- Splicing factor ess-2 homolog (52 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Homo sapiens)
- Splicing factor c9orf78 (33 kDa, Protein from Homo sapiens)
- Nf-kappa-b-activating protein (47 kDa, Protein from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7dvq
Q-score: 0.432
Bai R, Wan R, Wang L, Xu K, Zhang Q, Lei J, Shi Y
Science (2021) 371 [ DOI: doi:10.1126/science.abg0879 Pubmed: 33509932 ]
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Sodium channel modifier 1 (25 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- G-patch domain and kow motifs-containing protein (52 kDa, Protein from Homo sapiens)
- The activated human minor spliceosome (human minor bact complex) (Complex from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Cysteine-rich pdz-binding protein (11 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- U6atac snrna (39 kDa, RNA from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- U12 snrna (48 kDa, RNA from Homo sapiens)
- Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Ring finger protein 113a (38 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Homo sapiens)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Homo sapiens)
- 5'-o-[(s)-hydroxy{[(r)-hydroxy{[(s)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine (537 Da, Ligand)
- Smad nuclear-interacting protein 1 (45 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Armadillo repeat-containing protein 7 (21 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase cwc27 homolog (53 kDa, Protein from Homo sapiens)
- Rna-binding protein 48 (41 kDa, Protein from Homo sapiens)
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from Homo sapiens)
- Pre-mrna (44 kDa, RNA from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- Bud13 homolog (70 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound, composite map
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7b9v
Q-score: 0.378
Wilkinson ME, Fica SM, Galej WP, Nagai K
Mol Cell (2021) 81 pp. 1439- [ Pubmed: 33705709 DOI: doi:10.1016/j.molcel.2021.02.021 ]
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor slu7 (44 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 18 (28 kDa, Protein from Saccharomyces cerevisiae)
- 5' exon of ubc4 mrna (15 kDa, RNA from Saccharomyces cerevisiae)
- Yeast c complex spliceosome with prp18/slu7 bound (2 MDa, Complex from Saccharomyces cerevisiae)
- Syf1 isoform 1 (100 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor slt11 (40 kDa, Protein from Saccharomyces cerevisiae)
- Unassigned structure (20 kDa, Protein from Saccharomyces cerevisiae)
- Ntc20 isoform 1 (15 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (68 kDa, RNA from Saccharomyces cerevisiae)
- Cwc22 isoform 1 (67 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae)
- U2 snrna (376 kDa, RNA from Saccharomyces cerevisiae)
- Potassium ion (39 Da, Ligand)
- U6 snrna (35 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-processing protein 45 (42 kDa, Protein from Saccharomyces cerevisiae)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pre-mrna-splicing factor atp-dependent rna helicase prp16 (121 kDa, Protein from Saccharomyces cerevisiae)
- Branched intron and 3' exon of ubc4 pre-mrna (30 kDa, RNA from Saccharomyces cerevisiae)
- Hlj1_g0053790.mrna.1.cds.1 (27 kDa, Protein from Saccharomyces cerevisiae)
- Bj4_g0054360.mrna.1.cds.1 (50 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc21 (15 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing helicase brr2 (246 kDa, Protein from Saccharomyces cerevisiae)
- Cdc40 isoform 1 (52 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc15 (19 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-processing factor 19 (56 kDa, Protein from Saccharomyces cerevisiae)
- D-chiro inositol hexakisphosphate (660 Da, Ligand)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor isy1 (27 kDa, Protein from Saccharomyces cerevisiae)
- Clf1 isoform 1 (82 kDa, Protein from Saccharomyces cerevisiae)
- Bud31 isoform 1 (18 kDa, Protein from Saccharomyces cerevisiae)
- Y55_g0042700.mrna.1.cds.1 (67 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc2 (38 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (279 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor syf2 (24 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor snu114 (114 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Bj4_g0027490.mrna.1.cds.1 (12 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc25 (20 kDa, Protein from Saccharomyces cerevisiae)
- Snt309 isoform 1 (20 kDa, Protein from Saccharomyces cerevisiae)
- Splicing factor yju2 (33 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 8.0 Å
EM Method: Single-particle
Fitted PDBs: 7abi
Q-score: 0.145
Townsend C, Leelaram MN, Agafonov DE, Dybkov O, Will CL, Bertram K, Urlaub H, Kastner B, Stark H, Luhrmann R
Science (2020) 370 [ DOI: doi:10.1126/science.abc3753 Pubmed: 33243851 ]
- Ubiquitin-like protein 5 (8 kDa, Protein from Human)
- Snw domain-containing protein 1 (61 kDa, Protein from Human)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Human)
- Zinc finger matrin-type protein 2 (23 kDa, Protein from Human)
- Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from Human)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Human)
- Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Human)
- Smad nuclear-interacting protein 1 (45 kDa, Protein from Human)
- Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Human)
- U6 snrna (34 kDa, RNA from Human)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Human)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Human)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Human)
- U2 snrna (60 kDa, RNA from Human)
- Protein bud31 homolog (17 kDa, Protein from Human)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Human)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Human)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Human)
- Human pre-bact-2 spliceosome (Complex)
- Beta-catenin-like protein 1 (65 kDa, Protein from Human)
- Cell division cycle 5-like protein (92 kDa, Protein from Human)
- Pre-mrna-splicing factor 38a (37 kDa, Protein from Human)
- Intron-binding protein aquarius (171 kDa, Protein from Human)
- Crooked neck-like protein 1 (100 kDa, Protein from Human)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Human)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Human)
- Human pre-bact-2 spliceosome (Complex from Homo sapiens)
- Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Human)
- Splicing factor 3b subunit 4 (44 kDa, Protein from Human)
- Dna/rna-binding protein kin17 (45 kDa, Protein from Human)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Human)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Human)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Human)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Human)
- Magnesium ion (24 Da, Ligand)
- Minx m3 pre-mrna (Complex from synthetic construct)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Human)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Human)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Human)
- Bud13 homolog (70 kDa, Protein from Human)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Human)
- Microfibrillar-associated protein 1 (52 kDa, Protein from Human)
- Inositol hexakisphosphate (660 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Human)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Human)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Human)
- U5 snrna (36 kDa, RNA from Human)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Human)
- Pleiotropic regulator 1 (57 kDa, Protein from Human)
- Minx m3 pre-mrna (103 kDa, RNA from synthetic construct)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Human)
Resolution: 7.8 Å
EM Method: Single-particle
Fitted PDBs: 7abg
Q-score: 0.147
Townsend C, Leelaram MN, Agafonov DE, Dybkov O, Will CL, Bertram K, Urlaub H, Kastner B, Stark H, Luhrmann R
Science (2020) 370 [ DOI: doi:10.1126/science.abc3753 Pubmed: 33243851 ]
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Pre-bact-1 spliceosomal complex (Complex from Homo sapiens)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm7 (11 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor 38a (37 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm4 (15 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm3 (11 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- Serine/arginine-rich splicing factor 1 (27 kDa, Protein from Homo sapiens)
- Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- 7-methyl-guanosine-5'-triphosphate-5'-guanosine (803 Da, Ligand)
- U6 snrna-associated sm-like protein lsm6 (9 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- Zinc finger matrin-type protein 2 (23 kDa, Protein from Homo sapiens)
- Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
- U5 snrna (36 kDa, RNA from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Smad nuclear-interacting protein 1 (45 kDa, Protein from Homo sapiens)
- Pre-bact-1 spliceosomal complex (Complex)
- Transcription elongation regulator 1 (124 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- Minx m3 pre-mrna (73 kDa, RNA from synthetic construct)
- Nuclear cap-binding protein subunit 2 (18 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Microfibrillar-associated protein 1 (52 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm5 (9 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm8 (10 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Ubiquitin-like protein 5 (8 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Nuclear cap-binding protein subunit 1 (91 kDa, Protein from Homo sapiens)
- U6 snrna-associated sm-like protein lsm2 (10 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- Ww domain-binding protein 11 (70 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
Resolution: 7.1 Å
EM Method: Single-particle
Fitted PDBs: 6y53
Q-score: 0.057
Zhang Z, Will CL, Bertram K, Dybkov O, Hartmuth K, Agafonov DE, Hofele R, Urlaub H, Kastner B, Luhrmann R, Stark H
Nature (2020) 583 pp. 310-313 [ Pubmed: 32494006 DOI: doi:10.1038/s41586-020-2344-3 ]
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Hiv tat-specific factor 1 (85 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Probable atp-dependent rna helicase ddx46 (117 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- Human 17s u2 snrnp (Complex from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
Saccharomyces cerevisiae spliceosomal E complex (UBC4)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6n7p
Q-score: 0.352
Li X, Liu S, Zhang L, Issaian A, Hill RC, Espinosa S, Shi S, Cui Y, Kappel K, Das R, Hansen KC, Zhou ZH, Zhao R
Nature (2019) 573 pp. 375-380 [ Pubmed: 31485080 DOI: doi:10.1038/s41586-019-1523-6 ]
- U1 small nuclear ribonucleoprotein 70 kda homolog (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein component prp42 (65 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Nuclear cap-binding protein complex subunit 1 (100 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein a (40 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Pre-mrna-processing factor 39 (74 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Pre-mrna-processing protein prp40 (69 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein c (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- U1 small nuclear ribonucleoprotein component snu71,u1 small nuclear ribonucleoprotein component snu71,snu71 (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 56 kda u1 small nuclear ribonucleoprotein component (56 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Protein luc7 (30 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Nuclear cap-binding protein subunit 2 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Protein nam8 (57 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- U1 snrna (182 kDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubc4 pre-mrna (81 kDa, RNA from Saccharomyces cerevisiae S288C)
- Saccharomyces cerevisiae spliceosomal e complex (ebc4) (Complex from Saccharomyces cerevisiae)