Structure of a B-state intermediate committed to discard (Bd-I state)
Soni K, Horvath A, Dybkov O, Schwan M, Trakansuebkul S, Flemming D, Wild K, Urlaub H, Fischer T, Sinning I
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01480-7 Pubmed: 39833470 ]
- Pre-mrna-splicing factor cwf11 (148 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing protein 45 (62 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf14 (17 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor spp42 (274 kDa, Protein from Schizosaccharomyces pombe)
- Peptidyl-prolyl cis-trans isomerase ppi1 (16 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf17 (37 kDa, Protein from Schizosaccharomyces pombe)
- U5snrna (38 kDa, RNA from Schizosaccharomyces pombe)
- U6snrna (31 kDa, RNA from Schizosaccharomyces pombe)
- Potassium ion (39 Da, Ligand)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein f (8 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf15 (30 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Schizosaccharomyces pombe)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna (9 kDa, RNA from Schizosaccharomyces pombe)
- Zinc ion (65 Da, Ligand)
- Pre-mrna-splicing factor cdc5 (86 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein e (9 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein-associated protein b (15 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf22 (102 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 17 (63 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf2 (44 kDa, Protein from Schizosaccharomyces pombe)
- Bd-i complex (Complex from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf5 (39 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Schizosaccharomyces pombe)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 19 (54 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf3 (92 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf10 (111 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Schizosaccharomyces pombe)
- Putative pre-mrna-splicing factor atp-dependent rna helicase c20h4.09 (73 kDa, Protein from Schizosaccharomyces pombe)
- Unk1 (1 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf21 (34 kDa, Protein from Schizosaccharomyces pombe)
- G-patch domain-containing protein c1486.03 (91 kDa, Protein from Schizosaccharomyces pombe)
- Uncharacterized protein c20h4.06c (60 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf4 (80 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf7 (21 kDa, Protein from Schizosaccharomyces pombe)
- U2snrna (59 kDa, RNA from Schizosaccharomyces pombe)
- Unk2 (29 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor prp5 (52 kDa, Protein from Schizosaccharomyces pombe)
Structure of a B-state intermediate committed to discard (Bd-II state)
Soni K, Horvath A, Dybkov O, Schwan M, Trakansuebkul S, Flemming D, Wild K, Urlaub H, Fischer T, Sinning I
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01480-7 Pubmed: 39833470 ]
- Pre-mrna-splicing factor cwf11 (148 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing protein 45 (62 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf14 (17 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor spp42 (274 kDa, Protein from Schizosaccharomyces pombe)
- Peptidyl-prolyl cis-trans isomerase ppi1 (16 kDa, Protein from Schizosaccharomyces pombe)
- Uncharacterized protein c17a2.08c (41 kDa, Protein from Schizosaccharomyces pombe)
- Unk3 (1 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf17 (37 kDa, Protein from Schizosaccharomyces pombe)
- U5snrna (38 kDa, RNA from Schizosaccharomyces pombe)
- U6snrna (31 kDa, RNA from Schizosaccharomyces pombe)
- Potassium ion (39 Da, Ligand)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Schizosaccharomyces pombe)
- Unk2 (4 kDa, Protein from Schizosaccharomyces pombe)
- Bd-ii complex (Complex from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein f (8 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf15 (30 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Schizosaccharomyces pombe)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna (9 kDa, RNA from Schizosaccharomyces pombe)
- Zinc ion (65 Da, Ligand)
- Pre-mrna-splicing factor cdc5 (86 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein e (9 kDa, Protein from Schizosaccharomyces pombe)
- Stress response protein bis1 (43 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein-associated protein b (15 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf22 (102 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 17 (63 kDa, Protein from Schizosaccharomyces pombe)
- Unk1 (29 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf2 (44 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf5 (39 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Schizosaccharomyces pombe)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-processing factor 19 (54 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf3 (92 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf10 (111 kDa, Protein from Schizosaccharomyces pombe)
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Schizosaccharomyces pombe)
- Putative pre-mrna-splicing factor atp-dependent rna helicase c20h4.09 (73 kDa, Protein from Schizosaccharomyces pombe)
- Protein saf4 (34 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf21 (34 kDa, Protein from Schizosaccharomyces pombe)
- G-patch domain-containing protein c1486.03 (91 kDa, Protein from Schizosaccharomyces pombe)
- Uncharacterized protein c20h4.06c (60 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf4 (80 kDa, Protein from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor cwf7 (21 kDa, Protein from Schizosaccharomyces pombe)
- U2snrna (59 kDa, RNA from Schizosaccharomyces pombe)
- Pre-mrna-splicing factor prp5 (52 kDa, Protein from Schizosaccharomyces pombe)
Yeast post-catalytic P complex spliceosome, state I, overall map
Resolution: 2.31 Å
EM Method: Single-particle
Fitted PDBs: 9dtr
Q-score: 0.419
Senn KA, Lipinski KA, Zeps NJ, Griffin AF, Wilkinson ME, Hoskins AA
bioRxiv (2024) [ DOI: doi:10.1101/2024.05.04.592262 Pubmed: 38746449 ]
- Small nuclear ribonucleoprotein sm d3 (11 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 18 (28 kDa, Protein from Saccharomyces cerevisiae)
- Yeast post-catalytic p complex spliceosome (2 MDa, Complex from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Saccharomyces cerevisiae)
- Ubc4 lariat-intron (30 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor atp-dependent rna helicase prp22 (130 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Pre-mrna-splicing factor cwc22 (67 kDa, Protein from Saccharomyces cerevisiae)
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Pre-mrna-splicing factor cef1 (67 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc2 (38 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Small nuclear ribonucleoprotein sm d1 (16 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein-associated protein b (22 kDa, Protein from Saccharomyces cerevisiae)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ubc4 mrna spliced exons (13 kDa, RNA from Saccharomyces cerevisiae)
- Inositol hexakisphosphate (660 Da, Ligand)
- U6 snrna (35 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-processing protein 45 (42 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor prp46 (50 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Saccharomyces cerevisiae)
- U2 small nuclear ribonucleoprotein a' (27 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor 8 (279 kDa, Protein from Saccharomyces cerevisiae)
- U2 small nuclear ribonucleoprotein b'' (12 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor snt309 (20 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor ntc20 (15 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor snu114 (114 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-processing factor 19 (56 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor bud31 (18 kDa, Protein from Saccharomyces cerevisiae)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor isy1 (28 kDa, Protein from Saccharomyces cerevisiae)
- U5 snrna (68 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor syf2 (24 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-processing factor 17 (52 kDa, Protein from Saccharomyces cerevisiae)
- U2 snrna (376 kDa, RNA from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor slt11 (40 kDa, Protein from Saccharomyces cerevisiae)
- Protein fyv6 (20 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc15 (19 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor clf1 (82 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor slu7 (44 kDa, Protein from Saccharomyces cerevisiae)
- Pre-mrna-splicing factor cwc21 (15 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM map of the Chlamydomonas C* complex from Cdc5L-Flag dataset
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xi2
Q-score: 0.381
EMBO J (2024) [ Pubmed: 39415054 DOI: doi:10.1038/s44318-024-00274-3 ]
- Magnesium ion (24 Da, Ligand)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Chlamydomonas reinhardtii)
- Syf1 (104 kDa, Protein from Chlamydomonas reinhardtii)
- Rbm22 (44 kDa, Protein from Chlamydomonas reinhardtii)
- Intron-binding protein aquarius (201 kDa, Protein from Chlamydomonas reinhardtii)
- Cdc5l (91 kDa, Protein from Chlamydomonas reinhardtii)
- Zinc ion (65 Da, Ligand)
- U5-40k (39 kDa, Protein from Chlamydomonas reinhardtii)
- Pre-mrna-splicing factor spf27 (32 kDa, Protein from Chlamydomonas reinhardtii)
- Sm protein f (9 kDa, Protein from Chlamydomonas reinhardtii)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- G10 protein (26 kDa, Protein from Chlamydomonas reinhardtii)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Chlamydomonas reinhardtii)
- U2 snrna (61 kDa, RNA from Chlamydomonas reinhardtii)
- Cwf21 domain-containing protein (80 kDa, Protein from Chlamydomonas reinhardtii)
- Ski-interacting protein skip snw domain-containing protein (73 kDa, Protein from Chlamydomonas reinhardtii)
- Mi domain-containing protein (102 kDa, Protein from Chlamydomonas reinhardtii)
- Plrg1 (56 kDa, Protein from Chlamydomonas reinhardtii)
- Rna (5'-r(p*cp*cp*gp*ap*ap*cp*g)-3') (2 kDa, RNA from Chlamydomonas reinhardtii)
- Rna (173-mer) (55 kDa, RNA from Chlamydomonas reinhardtii)
- Ppiase cyclophilin-type domain-containing protein (61 kDa, Protein from Chlamydomonas reinhardtii)
- Cwf15/cwc15 cell cycle control protein (26 kDa, Protein from Chlamydomonas reinhardtii)
- Chlamydomonas c* complex (Complex from Chlamydomonas reinhardtii)
- U5 snrna (35 kDa, RNA from Chlamydomonas reinhardtii)
- Peptidyl-prolyl cis-trans isomerase (17 kDa, Protein from Chlamydomonas reinhardtii)
- Pre-mrna-processing factor 19 (54 kDa, Protein from Chlamydomonas reinhardtii)
- Small nuclear ribonucleoprotein sm d1 (12 kDa, Protein from Chlamydomonas reinhardtii)
- Elongation factor tu, chloroplastic (109 kDa, Protein from Chlamydomonas reinhardtii)
- Prp17 (63 kDa, Protein from Chlamydomonas reinhardtii)
- Mpn domain-containing protein (278 kDa, Protein from Chlamydomonas reinhardtii)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Chlamydomonas reinhardtii)
- Small nuclear ribonucleoprotein sm d2 (12 kDa, Protein from Chlamydomonas reinhardtii)
- Sm domain-containing protein (27 kDa, Protein from Chlamydomonas reinhardtii)
- Crooked neck protein (96 kDa, Protein from Chlamydomonas reinhardtii)
- U6 snrna (32 kDa, RNA from Chlamydomonas reinhardtii)
Integrative Structure of the human intron lariat Spliceosome (ILS'')
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ro2
Q-score: 0.297
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
- U2 snrna (60 kDa, RNA from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Human intron-lariat splicoesome (Complex from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Pax3- and pax7-binding protein 1 (104 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Cwf19-like protein 1 (60 kDa, Protein from Homo sapiens)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Coiled-coil domain-containing protein 12 (19 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 17 (65 kDa, Protein from Homo sapiens)
- Splicing factor ess-2 homolog (52 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Atp-dependent rna helicase dhx15 (91 kDa, Protein from Homo sapiens)
- U5 snrna (36 kDa, RNA from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Intron-binding protein aquarius (171 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
- Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
- Pre-mrna-processing factor 19 (55 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
- Cwf19-like protein 2 (103 kDa, Protein from Homo sapiens)
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- Intron (30 kDa, RNA from Homo sapiens)
- Splicing regulator sde2 (49 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
- Tuftelin-interacting protein 11 (96 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from Homo sapiens)
Composite map of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS')
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ro0
Q-score: 0.372
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ DOI: doi:10.1038/s41586-024-07741-1 Pubmed: 38925148 ]
- Probable small nuclear ribonucleoprotein f (9 kDa, Protein from Caenorhabditis elegans)
- Tpr_region domain-containing protein (88 kDa, Protein from Caenorhabditis elegans)
- Cell division cycle 5-like protein (85 kDa, Protein from Caenorhabditis elegans)
- Uncharacterized protein t27f2.1 (60 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (54 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor rbm22 (45 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Caenorhabditis elegans)
- Probable u2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor spf27 (27 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d3 (14 kDa, Protein from Caenorhabditis elegans)
- Rrm domain-containing protein (24 kDa, Protein from Caenorhabditis elegans)
- Intron lariat spliceosome (Complex from Caenorhabditis elegans)
- Protein bud31 homolog (17 kDa, Protein from Caenorhabditis elegans)
- Intron-binding protein aquarius (170 kDa, Protein from Caenorhabditis elegans)
- U2 snrna (56 kDa, RNA from Caenorhabditis elegans)
- Pre-mrna-splicing factor 8 homolog (272 kDa, Protein from Caenorhabditis elegans)
- U5 snrna (38 kDa, RNA from Caenorhabditis elegans)
- Protein isy-1 (31 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase (18 kDa, Protein from Caenorhabditis elegans)
- Coiled-coil domain-containing protein 12 (19 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf1 (99 kDa, Protein from Caenorhabditis elegans)
- Septin and tuftelin-interacting protein 1 homolog (94 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein e (10 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase e (36 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (36 kDa, Protein from Caenorhabditis elegans)
- Intron lariat rna (3 kDa, DNA from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Tr-type g domain-containing protein (110 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf-2 (27 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-processing factor 19 (53 kDa, Protein from Caenorhabditis elegans)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein-associated protein b (16 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (65 kDa, Protein from Caenorhabditis elegans)
- Inositol hexakisphosphate (660 Da, Ligand)
- U6 snrna (32 kDa, RNA from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein g (8 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Caenorhabditis elegans)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Gcf c-terminal domain-containing protein (94 kDa, Protein from Caenorhabditis elegans)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Caenorhabditis elegans)
Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'')
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ro1
Q-score: 0.373
Vorlander MK, Rothe P, Kleifeld J, Cormack ED, Veleti L, Riabov-Bassat D, Fin L, Phillips AW, Cochella L, Plaschka C
Nature (2024) 632 pp. 443-450 [ Pubmed: 38925148 DOI: doi:10.1038/s41586-024-07741-1 ]
- Wd_repeats_region domain-containing protein (54 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein g (8 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein-associated protein b (16 kDa, Protein from Caenorhabditis elegans)
- Uncharacterized protein t27f2.1 (60 kDa, Protein from Caenorhabditis elegans)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Caenorhabditis elegans)
- Rrm domain-containing protein (24 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor 8 homolog (272 kDa, Protein from Caenorhabditis elegans)
- Intron-binding protein aquarius (170 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor rbm22 (45 kDa, Protein from Caenorhabditis elegans)
- Zinc ion (65 Da, Ligand)
- Wd_repeats_region domain-containing protein (65 kDa, Protein from Caenorhabditis elegans)
- Tpr_region domain-containing protein (88 kDa, Protein from Caenorhabditis elegans)
- Wd_repeats_region domain-containing protein (36 kDa, Protein from Caenorhabditis elegans)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- U5 snrna (35 kDa, RNA from Caenorhabditis elegans)
- Inositol hexakisphosphate (660 Da, Ligand)
- Intron lariat spliceosome (ils'') (Complex from Caenorhabditis elegans)
- U6 snrna (32 kDa, RNA from Caenorhabditis elegans)
- Tr-type g domain-containing protein (110 kDa, Protein from Caenorhabditis elegans)
- Septin and tuftelin-interacting protein 1 homolog (94 kDa, Protein from Caenorhabditis elegans)
- Probable u2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Caenorhabditis elegans)
- Protein isy-1 (31 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor atp-dependent rna helicase ddx-15 (84 kDa, Protein from Caenorhabditis elegans)
- Cell division cycle 5-like protein (85 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein f (9 kDa, Protein from Caenorhabditis elegans)
- U2 snrna (68 kDa, RNA from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d3 (14 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf-2 (27 kDa, Protein from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Caenorhabditis elegans)
- Gcf c-terminal domain-containing protein (94 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-processing factor 19 (53 kDa, Protein from Caenorhabditis elegans)
- Cwf19-like protein 2 homolog (53 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase e (8 kDa, Protein from Caenorhabditis elegans)
- Intron lariat rna (10 kDa, RNA from Caenorhabditis elegans)
- Probable small nuclear ribonucleoprotein e (10 kDa, Protein from Caenorhabditis elegans)
- Protein bud31 homolog (17 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor spf27 (27 kDa, Protein from Caenorhabditis elegans)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Caenorhabditis elegans)
- Coiled-coil domain-containing protein 12 (8 kDa, Protein from Caenorhabditis elegans)
- Cwf19-like protein 1 homolog (59 kDa, Protein from Caenorhabditis elegans)
- Replication stress response regulator sde2 (57 kDa, Protein from Caenorhabditis elegans)
- Peptidyl-prolyl cis-trans isomerase (18 kDa, Protein from Caenorhabditis elegans)
- Pre-mrna-splicing factor syf1 (99 kDa, Protein from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
The cryo-EM structure of human pre-Bact complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8i0p
Q-score: 0.287
Nat Commun (2024) 15 pp. 6348-6348 [ DOI: doi:10.1038/s41467-024-50785-0 Pubmed: 39068178 ]
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- Human pre-bact complex (Complex from unidentified adenovirus)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Smad nuclear-interacting protein 1 (45 kDa, Protein from Homo sapiens)
- The human pre-bact complex (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Bud13 homolog (70 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- Pre-mrna (Complex)
- Pre-mrna (70 kDa, RNA from unidentified adenovirus)
- Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- Unknown polymer (2 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Rna helicase aquarius (171 kDa, Protein from Homo sapiens)
- Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Dna/rna-binding protein kin17 (45 kDa, Protein from Homo sapiens)
The cryo-EM structure of human Bact-I complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8i0r
Q-score: 0.388
Nat Commun (2024) 15 pp. 6348-6348 [ DOI: doi:10.1038/s41467-024-50785-0 Pubmed: 39068178 ]
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Smad nuclear-interacting protein 1 (45 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Ring finger protein 113a (38 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Bud13 homolog (70 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- The human bact-i complex (Complex from Homo sapiens)
- Pre-mrna (70 kDa, RNA from unidentified adenovirus)
- Pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from Homo sapiens)
- Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
- Unknown polymer (10 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Rna helicase aquarius (171 kDa, Protein from Homo sapiens)
- Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase cwc27 homolog (53 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
The cryo-EM structure of human Bact-II complex
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8i0s
Q-score: 0.15
Nat Commun (2024) 15 pp. 6348-6348 [ DOI: doi:10.1038/s41467-024-50785-0 Pubmed: 39068178 ]
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
- Ring finger protein 113a (38 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase-like 4 (57 kDa, Protein from Homo sapiens)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
- Pre-mrna (70 kDa, RNA from unidentified adenovirus)
- Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
- U6 snrna (34 kDa, RNA from Homo sapiens)
- Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
- U5 snrna (37 kDa, RNA from Homo sapiens)
- Rna helicase aquarius (171 kDa, Protein from Homo sapiens)
- Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from Homo sapiens)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- The human bact-ii complex (Complex from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)