Cryo-EM structure of a human-cockroach hybrid Nav channel.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6nt3
Q-score: 0.468
Clairfeuille T, Rohou A, Payandeh J
Science (2019) [ ]
- Navpas-vsd4 (155 kDa, Complex from Periplaneta americana)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Digitonin (1 kDa, Ligand)
- Sodium channel protein type 9 subunit alpha, sodium channel protein pafpc1, chimeric construct (178 kDa, Protein from Periplaneta americana)
- (7e,21r,24s)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9z,12e)-octadeca-9,12-dienoate (742 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2.
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6nt4
Q-score: 0.444
Clairfeuille T, Cloake A, Infield DT, Llongueras JP, Arthur CP, Li ZR, Jian Y, Martin-Eauclaire MF, Bougis PE, Ciferri C, Ahern CA, Bosmans F, Hackos DH, Rohou A, Payandeh J
Science (2019) 363 [ Pubmed: 30733386 DOI: doi:10.1126/science.aav8573 ]
- Alpha-mammal toxin aah2 (7 kDa, Protein from Androctonus australis)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Sodium channel protein pafpc1,sodium channel protein type 9 subunit alpha,sodium channel protein pafpc1 (178 kDa, Protein from Periplaneta americana)
- Digitonin (1 kDa, Ligand)
- Navpas-vsd4-aah2 (155 kDa, Complex from Periplaneta americana)
- (7e,21r,24s)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9z,12e)-octadeca-9,12-dienoate (742 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6a90
Q-score: 0.56
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana and dc1a (200 kDa, Complex)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
- Sodium ion (22 Da, Ligand)
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6a91
Q-score: 0.515
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Water (18 Da, Ligand)
- [(3as,4r,10as)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3h,8h-pyrrolo[1,2-c]purin-4-yl]methyl carbamate (299 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6a95
Q-score: 0.565
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N
Science (2018) 362 [ DOI: doi:10.1126/science.aau2596 Pubmed: 30049784 ]
- Water (18 Da, Ligand)
- (1r,5r,6r,7r,9s,11s,12s,13s,14s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name) (319 Da, Ligand)
- Voltage-gated sodium channel navpas from american cockroach periplaneta americana (Complex from Periplaneta americana)
- Mu-diguetoxin-dc1a (6 kDa, Protein from Diguetia canities)
- Sodium ion (22 Da, Ligand)
- Complex of voltage-gated sodium channel navpas from american cockroach periplaneta americana bound with saxitoxin and dc1a (200 kDa, Complex)
- Sodium channel protein pafpc1 (183 kDa, Protein from Periplaneta americana)
- Dc1a (Complex from Diguetia canities)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)