Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6p2j
Q-score: 0.453
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ Pubmed: 32433614 DOI: doi:10.1038/s41586-020-2290-0 ]
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Acat1 (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6p2p
Q-score: 0.462
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N
Nature (2020) 581 pp. 333-338 [ Pubmed: 32433614 DOI: doi:10.1038/s41586-020-2290-0 ]
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Acat1 (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (69 kDa, Protein from Homo sapiens)
Structure of nevanimibe-bound human tetrameric ACAT1
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 6vum
Q-score: 0.45
Long T, Sun Y, Hassan A, Qi X, Li X
Nature (2020) 581 pp. 339-343 [ Pubmed: 32433613 DOI: doi:10.1038/s41586-020-2295-8 ]
- Nevanimibe (421 Da, Ligand)
- Oleic acid (282 Da, Ligand)
- Acat1 (Cell from Homo sapiens)
- Coenzyme a (767 Da, Ligand)
- Sterol o-acyltransferase 1 (65 kDa, Protein from Homo sapiens)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Cholesterol (386 Da, Ligand)
Structure of the human sterol O-acyltransferase 1 in complex with CI-976
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6l47
Q-score: 0.397
Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L
Nat Commun (2020) 11 pp. 2478-2478 [ Pubmed: 32424158 DOI: doi:10.1038/s41467-020-16288-4 ]
- Human sterol o-acyltransferase 1 dimer (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (57 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)dodecanamide (393 Da, Ligand)
Structure of the human sterol O-acyltransferase 1 in resting state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6l48
Q-score: 0.414
Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L
Nat Commun (2020) 11 pp. 2478-2478 [ Pubmed: 32424158 DOI: doi:10.1038/s41467-020-16288-4 ]
- Human sterol o-acyltransferase 1 dimer (Complex from Homo sapiens)
- Sterol o-acyltransferase 1 (57 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)