Cryo-EM structure of rat SLC22A6 in the apo state
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8bvr
Q-score: 0.414
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Phosphate ion (94 Da, Ligand)
- Solute carrier family 22 member 6 (Complex from Rattus norvegicus)
- Synthetic nanobody (sybody) (Complex from Synthetic construct)
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- Oat1 (Complex)
Cryo-EM structure of rat SLC22A6 bound to tenofovir
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8bvs
Q-score: 0.402
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- [2-(6-amino-9h-purin-9-yl)-1-methylethoxy]methylphosphonic acid (287 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Oat1 (Complex from Rattus norvegicus)
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
Cryo-EM structure of rat SLC22A6 bound to probenecid
Resolution: 3.94 Å
EM Method: Single-particle
Fitted PDBs: 8bvt
Q-score: 0.364
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Oat1 (Complex from Rattus norvegicus)
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8bw7
Q-score: 0.389
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Chloride ion (35 Da, Ligand)
- Oat1 (Complex from Rattus norvegicus)
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- 2-oxoglutaric acid (146 Da, Ligand)
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid in a low occupancy state
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8omu
Q-score: 0.411
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- Oat1 (Complex from Rattus norvegicus)
CryoEm structure of SARS-CoV-2 spike protein (S-6P, 1-up) in complex with sybodies (Sb45)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 7n0g
Q-score: 0.397
Ahmad J, Jiang J, Boyd LF, Zeher A, Huang R, Xia D, Natarajan K, Margulies DH
J Biol Chem (2021) 297 pp. 101202-101202 [ Pubmed: 34537245 DOI: doi:10.1016/j.jbc.2021.101202 ]
- Spike protein (s-6p) in complex with synthetic nanobody (sb45) (600 kDa, Complex from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Synthetic nanobody (sybody), sb45 (13 kDa, Protein from synthetic construct)