Human TRiC-PhLP2A complex in the closed state
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8i1u
Q-score: 0.506
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- Aluminum fluoride (83 Da, Ligand)
- Complex of tric/cct-phlp2a treated with atp-alfx (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Phlp2a (pdcl3) (Complex)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Human tric/cct complex (Complex from Homo sapiens)
Human TRiC-PhLP2A complex in the open state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8i9u
Q-score: 0.286
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Complex of human tric/cct and phlp2a (1 MDa, Complex)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- Human tric/cct complex (Complex from Homo sapiens)
- Phlp2a (pdcl3) in human tric/cct complex (Complex from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
The focused refinement of CCT4-PhLP2A from TRiC-PhLP2A complex in the open state
Resolution: 4.22 Å
EM Method: Single-particle
Fitted PDBs: 8i9q
Q-score: 0.318
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- Complex of human tric/cct-phlp2a (1 MDa, Complex)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta from human tric/cct complex (Complex from Homo sapiens)
- Phlp2a (pdcl3) (Complex from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
Human TRiC-PhLP2A-actin complex in the closed state
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 8ib8
Q-score: 0.271
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- Actb protein (fragment) (41 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- Human actin (Complex from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Complex of tric/cct, phlp2a, and actin treated with atp-alfx (1 MDa, Complex)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- Human tric/cct complex (Complex from Homo sapiens)
- Phlp2a (pdcl3) (Complex from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
The beta-tubulin folding intermediate I
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7trg
Q-score: 0.549
Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J
Cell (2022) 185 pp. 4770-4787.e20 [ DOI: doi:10.1016/j.cell.2022.11.014 Pubmed: 36493755 ]
- Water (18 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (60 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Aluminum fluoride (83 Da, Ligand)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Closed form human tric in complex with beta-tubulin under atp/alf3condition. (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
The beta-tubulin folding intermediate II
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ttn
Q-score: 0.526
Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J
Cell (2022) 185 pp. 4770-4787.e20 [ DOI: doi:10.1016/j.cell.2022.11.014 Pubmed: 36493755 ]
- T-complex protein 1 subunit eta (60 kDa, Protein from Homo sapiens)
- Aluminum fluoride (83 Da, Ligand)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Closed form human tric in complex with beta-tubulin under atp/alfx condition. (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
The beta-tubulin folding intermediate III
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7ttt
Q-score: 0.561
Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J
Cell (2022) 185 pp. 4770-4787.e20 [ DOI: doi:10.1016/j.cell.2022.11.014 Pubmed: 36493755 ]
- Water (18 Da, Ligand)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Aluminum fluoride (83 Da, Ligand)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- T-complex protein 1 subunit eta (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- Closed form human tric in complex with beta-tubulin under atp/alfx condition. (1 MDa, Complex from Homo sapiens)
The beta-tubulin folding intermediate IV
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7tub
Q-score: 0.5
Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J
Cell (2022) 185 pp. 4770-4787.e20 [ DOI: doi:10.1016/j.cell.2022.11.014 Pubmed: 36493755 ]
- Water (18 Da, Ligand)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Aluminum fluoride (83 Da, Ligand)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- T-complex protein 1 subunit eta (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- Closed form human tric in complex with beta-tubulin under atp/alfx condition. (1 MDa, Complex from Homo sapiens)
Prefoldin-tubulin-TRiC complex
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7wu7
Q-score: 0.302
Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J
Cell (2022) 185 pp. 4770-4787.e20 [ DOI: doi:10.1016/j.cell.2022.11.014 Pubmed: 36493755 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Prefoldin subunit 5 (16 kDa, Protein from Homo sapiens)
- Prefoldin subunit 4 (16 kDa, Protein from Homo sapiens)
- Prefoldin subunit 3 (22 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- Prefoldin subunit 1 (14 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Prefoldin subunit 6 (14 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Prefoldin subunit 2 (16 kDa, Protein from Homo sapiens)
- Ternary complex of tric/cct, beta-tubulin, prefoldin complex (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
TRiC-substrate complex in ATP/AlFx closed state
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7lum
Q-score: 0.291
Knowlton JJ, Gestaut D, Ma B, Taylor G, Seven AB, Leitner A, Wilson GJ, Shanker S, Yates NA, Prasad BVV, Aebersold R, Chiu W, Frydman J, Dermody TS
PNAS (2021) 118 [ Pubmed: 33836586 DOI: doi:10.1073/pnas.2018127118 ]
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- Human tric/cct complex (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)