Human CST-DNA polymerase alpha/primase preinitiation complex bound to 3xTEL template
He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ
Nature (2022) 608 pp. 826-832 [ Pubmed: 35830881 DOI: doi:10.1038/s41586-022-05040-1 ]
- Ten1 (Protein from Homo sapiens)
- Pola2 (Protein from Homo sapiens)
- Prim2 (Protein from Homo sapiens)
- Prim1 (Protein from Homo sapiens)
- Pola1 (Protein from Homo sapiens)
- C-3xtel (DNA from Homo sapiens)
- Stn1 (Protein from Homo sapiens)
- Human cst-dna polymerase alpha/primase preinitiation complex bound to 3xtel template (540 kDa, Complex from Homo sapiens)
- Ctc1 (Protein from Homo sapiens)
He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ
Nature (2022) 608 pp. 826-832 [ Pubmed: 35830881 DOI: doi:10.1038/s41586-022-05040-1 ]
- Ten1 (Protein from Homo sapiens)
- Human cst-dna polymerase alpha/primase preinitiation complex bound to 3xtel template - local refined domains and merged (540 kDa, Complex from Homo sapiens)
- Pola2 (Protein from Homo sapiens)
- Prim2 (Protein from Homo sapiens)
- Prim1 (Protein from Homo sapiens)
- Pola1 (Protein from Homo sapiens)
- C-3xtel (DNA from Homo sapiens)
- Stn1 (Protein from Homo sapiens)
- Ctc1 (Protein from Homo sapiens)
Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7u5c
Q-score: 0.33
Cai SW, Zinder JC, Svetlov V, Bush MW, Nudler E, Walz T, de Lange T
Nat Struct Mol Biol (2022) 29 pp. 813-819 [ Pubmed: 35578024 DOI: doi:10.1038/s41594-022-00766-y ]
- Dna polymerase alpha subunit b (66 kDa, Protein from Homo sapiens)
- Cst complex subunit stn1 (42 kDa, Protein from Homo sapiens)
- Dna primase small subunit (49 kDa, Protein from Homo sapiens)
- Cst complex subunit ctc1 (135 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna primase large subunit (59 kDa, Protein from Homo sapiens)
- Canonical telomeric dna sequence (5 kDa, DNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cst complex subunit ten1 (13 kDa, Protein from Homo sapiens)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Homo sapiens)
- Human cst bound to dna polymerase alpha(pola1 delta n)-primase in a recruitment state (500 kDa, Complex)
Human CST bound to full-length DNA polymerase alpha-primase in a recruitment state
Cai SW, Zinder JC, Svetlov V, Bush MW, Nudler E, Walz T, de Lange T
Nat Struct Mol Biol (2022) 29 pp. 813-819 [ Pubmed: 35578024 DOI: doi:10.1038/s41594-022-00766-y ]
- Cst bound to full-length dna polymerase alpha-primase and ssdna (540 kDa, Complex)
- Cst complex subunit stn1 (Protein from Homo sapiens)
- Dna primase large subunit prim2 (Protein from Homo sapiens)
- Telomeric g-strand ssdna (3 repeats) (DNA from Homo sapiens)
- Cst complex subunit ten1 (Protein from Homo sapiens)
- Dna primase catalytic subunit (Protein from Homo sapiens)
- Dna polymerase alpha catalytic subunit pola1 (Protein from Homo sapiens)
- Dna polymerase alpha b subunit pola2 (Protein from Homo sapiens)
- Cst complex subunit ctc1 (Protein from Homo sapiens)
The structure of human CST reveals a decameric assembly bound to telomeric DNA
Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR
Science (2020) 368 pp. 1081-1085 [ Pubmed: 32499435 DOI: doi:10.1126/science.aaz9649 ]
- 3xtel (DNA from Homo sapiens)
- Homo sapiens cst complex subunit ctc1 (Protein from Homo sapiens)
- Homo sapiens cst complex subunit stn1 (Protein from Homo sapiens)
- Homo sapiens cst complex subunit ten1 (Protein from Homo sapiens)
- Decameric assembly of human cst complex with telomeric single-stranded dna (2 MDa, Complex from Homo sapiens)