Cryo-EM structure of bovine Fallopian tube cilia doublet microtubule (48-nm periodicity)
Leung MR, Sun C, Zeng J, Anderson JR, Niu Q, Huang W, Noteborn WEM, Brown A, Zeev-Ben-Mordehai T, Zhang R
Nature (2025) 637 pp. 1170-1177 [ DOI: doi:10.1038/s41586-024-08337-5 Pubmed: 39743588 ]
- Coiled-coil domain containing 173 (65 kDa, Protein from Bos taurus)
- Pierce1 (15 kDa, Protein from Bos taurus)
- Bovine fallopian tube cilia (Cellular component from Bos taurus)
- Armadillo repeat containing 4 (116 kDa, Protein from Bos taurus)
- Sperm acrosome associated 9 (19 kDa, Protein from Bos taurus)
- Sperm associated antigen 8 (51 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Protein flattop (21 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 90 (16 kDa, Protein from Bos taurus)
- Cfap141 (12 kDa, Protein from Bos taurus)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Bos taurus)
- Ef-hand domain family member b (97 kDa, Protein from Bos taurus)
- Enkurin, trpc channel interacting protein (30 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Bos taurus)
- Cfap95 (26 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 77 (32 kDa, Protein from Bos taurus)
- Cilia-and flagella-associated protein 96 (34 kDa, Protein from Bos taurus)
- Ciliary microtubule associated protein 1a (27 kDa, Protein from Bos taurus)
- Tubulin beta-4b chain (49 kDa, Protein from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Methyl-cpg binding domain protein 1 (62 kDa, Protein from Bos taurus)
- Ciliary microtubule associated protein 1c (30 kDa, Protein from Bos taurus)
- Tektin-4 (52 kDa, Protein from Bos taurus)
- Ef-hand calcium-binding domain-containing protein 1 (24 kDa, Protein from Bos taurus)
- Rib43a-like with coiled-coils protein 2 (44 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 144 (16 kDa, Protein from Bos taurus)
- Nucleoside diphosphate kinase 7 (42 kDa, Protein from Bos taurus)
- Ef-hand calcium binding domain 6 (162 kDa, Protein from Bos taurus)
- Tektin-3 (56 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 52 (68 kDa, Protein from Bos taurus)
- Ttc25 protein (78 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Outer dynein arm-docking complex subunit 3 (72 kDa, Protein from Bos taurus)
- Ef-hand domain containing 1 (74 kDa, Protein from Bos taurus)
- Pacrg protein (29 kDa, Protein from Bos taurus)
- Tektin-2 (49 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 161 (36 kDa, Protein from Bos taurus)
- Tubulin alpha-1d chain (50 kDa, Protein from Bos taurus)
- Uncharacterized protein c1orf158 homolog (23 kDa, Protein from Bos taurus)
- Protein fam166b (30 kDa, Protein from Bos taurus)
- Cfap276 (19 kDa, Protein from Bos taurus)
- Pierce2 (13 kDa, Protein from Bos taurus)
- Efhc2 (85 kDa, Protein from Bos taurus)
- Coiled-coil domain containing 114 (77 kDa, Protein from Bos taurus)
- Tektin-1 (48 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 45 (65 kDa, Protein from Bos taurus)
48-nm repeat of the native axonemal doublet microtubule from bovine sperm
Leung MR, Zeng J, Wang X, Roelofs MC, Huang W, Zenezini Chiozzi R, Hevler JF, Heck AJR, Dutcher SK, Brown A, Zhang R, Zeev-Ben-Mordehai T
Cell (2023) 186 pp. 2880-2896.e17 [ Pubmed: 37327785 DOI: doi:10.1016/j.cell.2023.05.026 ]
- Ef-hand domain-containing protein (31 kDa, Protein from Bos taurus)
- Nucleoside diphosphate kinase 7 (42 kDa, Protein from Bos taurus)
- Spermatid-specific manchette-related protein 1 (35 kDa, Protein from Bos taurus)
- Tektin-2 (49 kDa, Protein from Bos taurus)
- Cilia- and flagella- associated protein 210 (65 kDa, Protein from Bos taurus)
- Parkin coregulated gene protein (29 kDa, Protein from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Cilia and flagella associated protein 77 (32 kDa, Protein from Bos taurus)
- Chromosome 13 c20orf85 homolog (15 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 53 (62 kDa, Protein from Bos taurus)
- Atp6v1f neighbor (20 kDa, Protein from Bos taurus)
- Tektin-3 (56 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 107 (23 kDa, Protein from Bos taurus)
- Tektin-5 (56 kDa, Protein from Bos taurus)
- Sperm-associated antigen 8 (51 kDa, Protein from Bos taurus)
- Piercer of microtubule wall 2 protein (13 kDa, Protein from Bos taurus)
- Enkurin (30 kDa, Protein from Bos taurus)
- Upf0602 protein c4orf47 homolog (34 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 68 (20 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Testis specific serine kinase 6 (30 kDa, Protein from Bos taurus)
- Testis-expressed protein 43 (15 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 95 (26 kDa, Protein from Bos taurus)
- Uncharacterized protein c10orf82 homolog (26 kDa, Protein from Bos taurus)
- Chromosome 19 c17orf98 homolog (17 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Bos taurus)
- Cfap97 domain containing 1 (19 kDa, Protein from Bos taurus)
- Tubulin alpha-3 chain (49 kDa, Protein from Bos taurus)
- Protein fam166c (23 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 276 (19 kDa, Protein from Bos taurus)
- Ef-hand domain-containing protein 1 (74 kDa, Protein from Bos taurus)
- Tepp protein (24 kDa, Protein from Bos taurus)
- Testis-expressed sequence 37 protein (20 kDa, Protein from Bos taurus)
- Rib43a-like with coiled-coils protein 2 (44 kDa, Protein from Bos taurus)
- Tektin bundle interacting protein 1 (24 kDa, Protein from Bos taurus)
- Outer dense fiber of sperm tails 3b (32 kDa, Protein from Bos taurus)
- Tektin-4 (52 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 141 (12 kDa, Protein from Bos taurus)
- Tektin-1 (48 kDa, Protein from Bos taurus)
- Stabilizer of axonemal microtubules 1 (40 kDa, Protein from Bos taurus)
- Tubulin beta-4b chain (49 kDa, Protein from Bos taurus)
- Testis expressed 49 (15 kDa, Protein from Bos taurus)
- Uncharacterized protein c4orf45 homolog (22 kDa, Protein from Bos taurus)
- Ef-hand domain-containing family member c2 (85 kDa, Protein from Bos taurus)
- Coiled-coil domain-containing protein 105 (57 kDa, Protein from Bos taurus)
- Outer dense fiber of sperm tails 3 (27 kDa, Protein from Bos taurus)
- Outer dense fiber of sperm tails 3 like 1 (30 kDa, Protein from Bos taurus)
- Dual specificity phosphatase 21 (22 kDa, Protein from Bos taurus)
- Sperm acrosome associated 9 (25 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from Bos taurus)
- Testis expressed 33 (30 kDa, Protein from Bos taurus)
- Chromosome 20 c5orf49 homolog (16 kDa, Protein from Bos taurus)
- Protein phosphatase 1 regulatory subunit 32 (47 kDa, Protein from Bos taurus)
- Family with sequence similarity 166 member a (36 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 144 (16 kDa, Protein from Bos taurus)
- Protein flattop (21 kDa, Protein from Bos taurus)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Bos taurus)
- Theg spermatid protein like (50 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 161 (36 kDa, Protein from Bos taurus)
- 48-nm repeat of the native axonemal doublet microtubule from bovine sperm (Complex from Bos taurus)
- Ef-hand calcium-binding domain-containing protein 3 (50 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Piercer of microtubule wall 1 protein (15 kDa, Protein from Bos taurus)
- Uncharacterized protein mgc137036 (21 kDa, Protein from Bos taurus)
- Ef-hand domain-containing family member b (97 kDa, Protein from Bos taurus)
- Chromosome 7 open reading frame 31 (67 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from Bos taurus)
- Spermatogenesis-associated protein 48 (49 kDa, Protein from Bos taurus)
- Stabilizer of axonemal microtubules 3 (37 kDa, Protein from Bos taurus)
- Uncharacterized protein c1orf100 homolog (16 kDa, Protein from Bos taurus)
Cryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8iyj
Q-score: 0.35
Zhou L, Liu H, Liu S, Yang X, Dong Y, Pan Y, Xiao Z, Zheng B, Sun Y, Huang P, Zhang X, Hu J, Sun R, Feng S, Zhu Y, Liu M, Gui M, Wu J
Cell (2023) 186 pp. 2897-2910.e19 [ DOI: doi:10.1016/j.cell.2023.05.009 Pubmed: 37295417 ]
- Coiled-coil domain-containing protein 105 (57 kDa, Protein from Mus musculus)
- Ef-hand domain-containing family member c2 (87 kDa, Protein from Mus musculus)
- Protein fam166a (36 kDa, Protein from Mus musculus)
- Ef-hand domain-containing protein 1 (75 kDa, Protein from Mus musculus)
- Uncharacterized protein c10orf82 homolog (25 kDa, Protein from Mus musculus)
- Testis-specific serine/threonine-protein kinase 6 (30 kDa, Protein from Mus musculus)
- Spermatid-specific manchette-related protein 1 (29 kDa, Protein from Mus musculus)
- Ef-hand domain-containing family member b (95 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 53 (62 kDa, Protein from Mus musculus)
- Rib43a-like with coiled-coils protein 1 (45 kDa, Protein from Mus musculus)
- Cilia and flagella-associated protein 77 (32 kDa, Protein from Mus musculus)
- Protein phosphatase 1 regulatory subunit 32 (47 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Mus musculus)
- Sperm-associated antigen 8 (50 kDa, Protein from Mus musculus)
- Piercer of microtubule wall 2 protein (13 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 95 (26 kDa, Protein from Mus musculus)
- Family with sequence similarity 183, member b (16 kDa, Protein from Mus musculus)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Mus musculus)
- Tektin-5 (62 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 141 (12 kDa, Protein from Mus musculus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Cilia- and flagella-associated protein 90 (20 kDa, Protein from Mus musculus)
- Tektin-4 (52 kDa, Protein from Mus musculus)
- Testis-expressed sequence 37 protein (21 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 107 (23 kDa, Protein from Mus musculus)
- Protein fam166c (23 kDa, Protein from Mus musculus)
- Rib43a-like with coiled-coils protein 2 (45 kDa, Protein from Mus musculus)
- Tektin-2 (50 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 161 (34 kDa, Protein from Mus musculus)
- Outer dense fiber protein 3 (27 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from Mus musculus)
- Enkurin (29 kDa, Protein from Mus musculus)
- Testis expressed 49 (15 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 68 (19 kDa, Protein from Mus musculus)
- Tektin-1 (48 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 276 (18 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from Mus musculus)
- Tektin bundle-interacting protein 1 (23 kDa, Protein from Mus musculus)
- Testis-expressed protein 43 (16 kDa, Protein from Mus musculus)
- Piercer of microtubule wall 1 protein (18 kDa, Protein from Mus musculus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Testis, prostate and placenta-expressed protein (24 kDa, Protein from Mus musculus)
- Ef-hand calcium-binding domain-containing protein 6 (176 kDa, Protein from Mus musculus)
- Tektin-3 (56 kDa, Protein from Mus musculus)
- Mouse sperm dmt (Complex from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Parkin coregulated gene protein homolog (27 kDa, Protein from Mus musculus)
- Cilia- and flagella-associated protein 210 (65 kDa, Protein from Mus musculus)
- Tubulin beta-4b chain (49 kDa, Protein from Mus musculus)
- Dual specificity phosphatase 21 (21 kDa, Protein from Mus musculus)
- Nucleoside diphosphate kinase 7 (44 kDa, Protein from Mus musculus)
- Tubulin alpha-3 chain (50 kDa, Protein from Mus musculus)
- Protein flattop (20 kDa, Protein from Mus musculus)
Composite cryo-EM density map of the 48-nm repeat of the human respiratory doublet microtubule
Gui M, Croft JT, Zabeo D, Acharya V, Kollman JM, Burgoyne T, Hoog JL, Brown A
PNAS (2022) 119 pp. e2207605119-e2207605119 [ Pubmed: 36191189 DOI: doi:10.1073/pnas.2207605119 ]
- Protein fam166b (30 kDa, Protein from Homo sapiens)
- Protein cfap276 (19 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Enkurin (29 kDa, Protein from Homo sapiens)
- Tektin-1 (48 kDa, Protein from Homo sapiens)
- Upf0686 protein c11orf1 (17 kDa, Protein from Homo sapiens)
- Rib43a-like with coiled-coils protein 2 (45 kDa, Protein from Homo sapiens)
- Sperm-associated antigen 8 (51 kDa, Protein from Homo sapiens)
- Ef-hand domain-containing family member c2 (87 kDa, Protein from Homo sapiens)
- Doublet microtubule and associated proteins (Complex from Homo sapiens)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from Homo sapiens)
- Cilia- and flagella-associated protein 53 (61 kDa, Protein from Homo sapiens)
- Parkin coregulated gene protein (29 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Sperm acrosome-associated protein 9 (25 kDa, Protein from Homo sapiens)
- Tektin-4 (50 kDa, Protein from Homo sapiens)
- Ef-hand domain-containing family member b (93 kDa, Protein from Homo sapiens)
- Ef-hand domain-containing protein 1 (74 kDa, Protein from Homo sapiens)
- Tubulin alpha-1a chain (50 kDa, Protein from Homo sapiens)
- Uncharacterized protein c15orf65 (13 kDa, Protein from Homo sapiens)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from Homo sapiens)
- Cilia- and flagella-associated protein 161 (34 kDa, Protein from Homo sapiens)
- Upf0691 protein c9orf116 (15 kDa, Protein from Homo sapiens)
- Nucleoside diphosphate kinase 7 (42 kDa, Protein from Homo sapiens)
- Protein cfap107 (23 kDa, Protein from Homo sapiens)
- Uncharacterized protein c5orf49 (17 kDa, Protein from Homo sapiens)
- Protein flattop (19 kDa, Protein from Homo sapiens)
- Protein fam183a (16 kDa, Protein from Homo sapiens)
- Protein fam166c (23 kDa, Protein from Homo sapiens)
- Protein cfap95 (26 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta-4b chain (49 kDa, Protein from Homo sapiens)
- Tektin-3 (56 kDa, Protein from Homo sapiens)
- Isoform 2 of cilia- and flagella-associated protein 77 (33 kDa, Protein from Homo sapiens)
- Protein cfap141 (12 kDa, Protein from Homo sapiens)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Homo sapiens)
- Tektin-2 (49 kDa, Protein from Homo sapiens)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Homo sapiens)
- Protein cfap210 (66 kDa, Protein from Homo sapiens)
Composite cryo-EM density map of the 48-nm repeat doublet microtubule from bovine tracheal cilia
Gui M, Farley H, Anujan P, Anderson JR, Maxwell DW, Whitchurch JB, Botsch JJ, Qiu T, Meleppattu S, Singh SK, Zhang Q, Thompson J, Lucas JS, Bingle CD, Norris DP, Roy S, Brown A
Cell (2021) 184 pp. 5791- [ DOI: doi:10.1016/j.cell.2021.10.007 Pubmed: 34715025 ]
- Nucleoside diphosphate kinase 7 (42 kDa, Protein from Bos taurus)
- Pacrg protein (29 kDa, Protein from Bos taurus)
- Tektin-2 (49 kDa, Protein from Bos taurus)
- Tubulin alpha-1d chain (50 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 52 (68 kDa, Protein from Bos taurus)
- Outer dynein arm-docking complex subunit 3 (72 kDa, Protein from Bos taurus)
- Efhc2 (85 kDa, Protein from Bos taurus)
- Efcab6 (172 kDa, Protein from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Sperm associated antigen 8 (51 kDa, Protein from Bos taurus)
- Ef-hand domain family member b (97 kDa, Protein from Bos taurus)
- Tektin-3 (56 kDa, Protein from Bos taurus)
- Pierce2 (13 kDa, Protein from Bos taurus)
- Ef-hand calcium-binding domain-containing protein 1 (24 kDa, Protein from Bos taurus)
- Cilia and flagella associated protein 161 (36 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Cilia and flagella associated protein 45 (65 kDa, Protein from Bos taurus)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from Bos taurus)
- Chromosome 3 c1orf194 homolog (19 kDa, Protein from Bos taurus)
- Doublet microtubule (Complex from Bos taurus)
- Uncharacterized protein c1orf158 homolog (23 kDa, Protein from Bos taurus)
- Rib43a-like with coiled-coils protein 2 (44 kDa, Protein from Bos taurus)
- Ef-hand domain containing 1 (74 kDa, Protein from Bos taurus)
- Tektin-4 (52 kDa, Protein from Bos taurus)
- Tektin-1 (48 kDa, Protein from Bos taurus)
- Tubulin beta-4b chain (49 kDa, Protein from Bos taurus)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from Bos taurus)
- Protein fam166b (30 kDa, Protein from Bos taurus)
- Protein c9orf135 homolog (26 kDa, Protein from Bos taurus)
- Coiled-coil domain containing 173 (65 kDa, Protein from Bos taurus)
- Methyl-cpg binding domain protein 1 (62 kDa, Protein from Bos taurus)
- Coiled-coil domain containing 114 (77 kDa, Protein from Bos taurus)
- Uncharacterized protein c1orf189 homolog (12 kDa, Protein from Bos taurus)
- Enkurin, trpc channel interacting protein (30 kDa, Protein from Bos taurus)
- Ttc25 protein (78 kDa, Protein from Bos taurus)
- Pierce1 (15 kDa, Protein from Bos taurus)
- Protein flattop (21 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Tektip1 (24 kDa, Protein from Bos taurus)
- Armadillo repeat containing 4 (116 kDa, Protein from Bos taurus)