Structure of apo telomeric nucleosome
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8ox0
Q-score: 0.607
Hu H, van Roon AM, Ghanim GE, Ahsan B, Oluwole AO, Peak-Chew SY, Robinson CV, Nguyen THD
Sci Adv (2023) 9 pp. eadi4148-eadi4148 [ DOI: doi:10.1126/sciadv.adi4148 Pubmed: 37624885 ]
- Water (18 Da, Ligand)
- Telomeric dna g strand (46 kDa, DNA from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Trf1core in complex with telomeric nucleosome (Complex)
- Histone h2a type 1-c (14 kDa, Protein from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Telomeric dna c strand (43 kDa, DNA from Homo sapiens)
- Histone h2b type 1-c/e/f/g/i (14 kDa, Protein from Homo sapiens)
- Human telomeric nucleosome (Complex from Homo sapiens)
Structure of TRF1core in complex with telomeric nucleosome
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ox1
Q-score: 0.579
Hu H, van Roon AM, Ghanim GE, Ahsan B, Oluwole AO, Peak-Chew SY, Robinson CV, Nguyen THD
Sci Adv (2023) 9 pp. eadi4148-eadi4148 [ DOI: doi:10.1126/sciadv.adi4148 Pubmed: 37624885 ]
- Water (18 Da, Ligand)
- Telomeric dna g strand (46 kDa, DNA from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Trf1core in complex with telomeric nucleosome (Complex)
- Histone h2a type 1-c (14 kDa, Protein from Homo sapiens)
- Telomeric repeat-binding factor 1 (50 kDa, Protein from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Telomeric dna c strand (43 kDa, DNA from Homo sapiens)
- Human trf1core complex (Complex from Homo sapiens)
- Telomeric repeat-binding factor 1 (50 kDa, Protein from Homo sapiens)
- Histone h2b type 1-c/e/f/g/i (14 kDa, Protein from Homo sapiens)
- Human telomeric nucleosome (Complex from Homo sapiens)
Structure of TRF1core in complex with telomeric nucleosome (4:1 complex)
Hu H, van Roon AM, Ghanim GE, Ahsan B, Oluwole AO, Peak-Chew SY, Robinson CV, Nguyen THD
Sci Adv (2023) 9 pp. eadi4148-eadi4148 [ DOI: doi:10.1126/sciadv.adi4148 Pubmed: 37624885 ]
- Telomeric dna g strand (DNA from Homo sapiens)
- Human histone h2b (Protein from Homo sapiens)
- Human trf1 protein (Protein from Homo sapiens)
- Trf1core in complex with telomeric nucleosome (Complex)
- Human histone h3 (Protein from Homo sapiens)
- Human histone h4 (Protein from Homo sapiens)
- Telomeric dna c strand (DNA from Homo sapiens)
- Human trf1core complex (Complex from Homo sapiens)
- Human telomeric nucleosome (Complex from Homo sapiens)
- Human histone h2a (Protein from Homo sapiens)
Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7u5c
Q-score: 0.33
Cai SW, Zinder JC, Svetlov V, Bush MW, Nudler E, Walz T, de Lange T
Nat Struct Mol Biol (2022) 29 pp. 813-819 [ Pubmed: 35578024 DOI: doi:10.1038/s41594-022-00766-y ]
- Dna polymerase alpha subunit b (66 kDa, Protein from Homo sapiens)
- Cst complex subunit stn1 (42 kDa, Protein from Homo sapiens)
- Dna primase small subunit (49 kDa, Protein from Homo sapiens)
- Cst complex subunit ctc1 (135 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna primase large subunit (59 kDa, Protein from Homo sapiens)
- Canonical telomeric dna sequence (5 kDa, DNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cst complex subunit ten1 (13 kDa, Protein from Homo sapiens)
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Homo sapiens)
- Human cst bound to dna polymerase alpha(pola1 delta n)-primase in a recruitment state (500 kDa, Complex)
Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7qxa
Q-score: 0.379
Sekne Z, Ghanim GE, van Roon AM, Nguyen THD
Science (2022) 375 pp. 1173-1176 [ Pubmed: 35201900 DOI: doi:10.1126/science.abn6840 ]
- Telomeric dna (Complex from Homo sapiens)
- Histones (Complex from Homo sapiens)
- Histone h2b (18 kDa, Protein from Homo sapiens)
- Tpp1 (Complex from Homo sapiens)
- Telomerase reverse transcriptase (127 kDa, Protein from Homo sapiens)
- Human telomerase rna (145 kDa, RNA from Homo sapiens)
- Adrenocortical dysplasia homolog (mouse), isoform cra_a (49 kDa, Protein from Homo sapiens)
- Telomerase reverse transcriptase and telomeric rna (Complex from Homo sapiens)
- Complex of telomeric dna-bound human telomerase with tpp1 (Complex)
- Telomeric dna (9 kDa, DNA from Homo sapiens)
- Histone h2a (14 kDa, Protein from Homo sapiens)
Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7qxb
Q-score: 0.278
Sekne Z, Ghanim GE, van Roon AM, Nguyen THD
Science (2022) 375 pp. 1173-1176 [ Pubmed: 35201900 DOI: doi:10.1126/science.abn6840 ]
- Telomeric dna (Complex from Homo sapiens)
- Histones (Complex from Homo sapiens)
- Histone h2b (18 kDa, Protein from Homo sapiens)
- Protection of telomeres protein 1 (71 kDa, Protein from Homo sapiens)
- Telomerase reverse transcriptase (127 kDa, Protein from Homo sapiens)
- Human telomerase rna (145 kDa, RNA from Homo sapiens)
- Adrenocortical dysplasia homolog (mouse), isoform cra_a (49 kDa, Protein from Homo sapiens)
- Tpp1-pot1 (Complex from Homo sapiens)
- Telomerase reverse transcriptase and telomeric rna (Complex from Homo sapiens)
- Telomeric dna (9 kDa, DNA from Homo sapiens)
- Histone h2a (14 kDa, Protein from Homo sapiens)
- Complex of telomeric dna-bound human telomerase with tpp1-pot1 (Complex)
Refined, unsharpened map of human telomerase-DNA-TPP1 complex
Sekne Z, Ghanim GE, van Roon AM, Nguyen THD
Science (2022) 375 pp. 1173-1176 [ Pubmed: 35201900 DOI: doi:10.1126/science.abn6840 ]
- Histone h2a (Protein from Homo sapiens)
- Complex of telomeric dna-bound human telomerase with tpp1 (Complex from Homo sapiens)
- Tpp1 (Protein from Homo sapiens)
- Telomerase reverse transcriptase (Protein from Homo sapiens)
- Histone h2b (Protein from Homo sapiens)
- Human telomerase rna (RNA from Homo sapiens)
- Telomeric dna (DNA from Homo sapiens)
Refined, unsharpened map of human telomerase-DNA-TPP1-POT1 complex
Sekne Z, Ghanim GE, van Roon AM, Nguyen THD
Science (2022) 375 pp. 1173-1176 [ Pubmed: 35201900 DOI: doi:10.1126/science.abn6840 ]
- Pot1 (Protein from Homo sapiens)
- Complex of telomeric dna-bound human telomerase with tpp1 and pot1 (Complex from Homo sapiens)
- Histone h2a (Protein from Homo sapiens)
- Tpp1 (Protein from Homo sapiens)
- Telomerase reverse transcriptase (Protein from Homo sapiens)
- Histone h2b (Protein from Homo sapiens)
- Human telomerase rna (RNA from Homo sapiens)
- Telomeric dna (DNA from Homo sapiens)
The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7bg9
Q-score: 0.346
Ghanim GE, Fountain AJ, van Roon AM, Rangan R, Das R, Collins K, Nguyen THD
Nature (2021) 593 pp. 449-453 [ Pubmed: 33883742 DOI: doi:10.1038/s41586-021-03415-4 ]
- Telomerase reverse transcriptase,telomerase reverse transcriptase (149 kDa, Protein from Homo sapiens)
- Histone h2b (18 kDa, Protein from Homo sapiens)
- Histone (Complex from Homo sapiens)
- Human telomerase catalytic core in complex with a telomeric dna substrate (Complex)
- Rna (256-mer) (145 kDa, RNA from Homo sapiens)
- Telomerase reverse transcriptase (Complex from Homo sapiens)
- Dna (5'-d(p*tp*tp*ap*gp*gp*g)-3') (5 kDa, DNA from synthetic construct)
- Dna (Complex from synthetic construct)
- Histone h2a (14 kDa, Protein from Homo sapiens)
CryoEM structure of Tetrahymena telomerase with telomeric DNA at 4.8 Angstrom resolution
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 6d6v
Q-score: 0.243
Jiang J, Wang Y, Susac L, Chan H, Basu R, Zhou ZH, Feigon J
Cell (2018) 173 pp. 1179-1190.e13 [ DOI: doi:10.1016/j.cell.2018.04.038 Pubmed: 29775593 ]
- Telomerase-associated protein 82 (82 kDa, Protein from Tetrahymena thermophila)
- Telomerase holoenzyme teb2 subunit (30 kDa, Protein from Tetrahymena thermophila)
- Endogenous assembled tetrahymena telomerase bound with telomeric dna (Complex from Tetrahymena thermophila)
- Zinc ion (65 Da, Ligand)
- Telomerase reverse transcriptase (133 kDa, Protein from Tetrahymena thermophila)
- Telomerase-associated protein 50 (13 kDa, Protein from Tetrahymena thermophila)
- Telomerase holoenzyme teb heterotrimer teb3 subunit (14 kDa, Protein from Tetrahymena thermophila)
- Telomerase associated protein p65 (64 kDa, Protein from Tetrahymena thermophila)
- Dna (5'-d(p*gp*tp*tp*gp*gp*gp*gp*tp*tp*gp*gp*gp*gp*tp*tp*gp*gp*gp*g)-3') (6 kDa, DNA from Tetrahymena thermophila)
- Rna (159-mer) (50 kDa, RNA from Tetrahymena thermophila)