Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8vsc
Q-score: 0.483
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ Pubmed: 39288764 DOI: doi:10.1016/j.cell.2024.08.036 ]
- Transforming growth factor beta activator lrrc32 (66 kDa, Protein from Homo sapiens)
- Transforming growth factor beta-1 proprotein (44 kDa, Protein from Homo sapiens)
- L-tgf-b1/garp complex (180 kDa, Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8vsd
Q-score: 0.508
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ Pubmed: 39288764 DOI: doi:10.1016/j.cell.2024.08.036 ]
- Integrin beta-8 (39 kDa, Protein from Homo sapiens)
- Avb8/l-tgf-b1/garp complex (180 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transforming growth factor beta activator lrrc32 (61 kDa, Protein from Homo sapiens)
- Transforming growth factor beta-1 proprotein (41 kDa, Protein from Homo sapiens)
- Avb8 complex (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Integrin alpha-v heavy chain (65 kDa, Protein from Homo sapiens)
- L-tgf-b1/garp complex (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6uja
Q-score: 0.462
Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
Cell (2020) 180 pp. 490- [ DOI: doi:10.1016/j.cell.2019.12.030 Pubmed: 31955848 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Integrin alpha-v (112 kDa, Protein from Homo sapiens)
- Integrin beta-8 (81 kDa, Protein from Homo sapiens)
- Transforming growth factor beta-1 proprotein (Complex from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Binary complex of integrin alpha-v beta-8 with latent tgf-beta-1 (l-tgf-b1) (260 kDa, Complex)
- Transforming growth factor beta-1 proprotein (41 kDa, Protein from Sus scrofa)
- Alpha-v beta-8 integrin (Complex from Homo sapiens)
Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
Cell (2020) 180 pp. 490-501.e16 [ DOI: doi:10.1016/j.cell.2019.12.030 Pubmed: 31955848 ]
Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
Cell (2020) 180 pp. 490-501.e16 [ DOI: doi:10.1016/j.cell.2019.12.030 Pubmed: 31955848 ]
Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
Cell (2020) 180 pp. 490-501.e16 [ DOI: doi:10.1016/j.cell.2019.12.030 Pubmed: 31955848 ]
Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
Cell (2020) 180 pp. 490-501.e16 [ DOI: doi:10.1016/j.cell.2019.12.030 Pubmed: 31955848 ]
Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
Cell (2020) 180 pp. 490-501.e16 [ DOI: doi:10.1016/j.cell.2019.12.030 Pubmed: 31955848 ]
Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
Cell (2020) 180 pp. 490-501.e16 [ DOI: doi:10.1016/j.cell.2019.12.030 Pubmed: 31955848 ]
Integrin alpha-v beta-8 in complex with pro-TGF-beta1
Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
Cell (2020) 180 pp. 490-501.e16 [ DOI: doi:10.1016/j.cell.2019.12.030 Pubmed: 31955848 ]