Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with primidone
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 9b28
Q-score: 0.438
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ Pubmed: 39809942 DOI: doi:10.1038/s41594-024-01463-8 ]
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Primidone (218 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with cholesteryl hemisuccinate
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 9b29
Q-score: 0.394
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ Pubmed: 39809942 DOI: doi:10.1038/s41594-024-01463-8 ]
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 9b2a
Q-score: 0.34
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ Pubmed: 39809942 DOI: doi:10.1038/s41594-024-01463-8 ]
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Pregnenolone sulfate (396 Da, Ligand)
- (2s)-2-(3,4-dihydroquinolin-1(2h)-yl)-n-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide (347 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8rcr
Q-score: 0.329
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Cholesterol (386 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (83 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8rcu
Q-score: 0.325
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- 4-chloranyl-2-[2-(3-iodanylphenoxy)ethanoylamino]benzoic acid (431 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (83 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8rd9
Q-score: 0.2
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Cholesterol (386 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (84 kDa, Protein from Homo sapiens)
- 4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)benzoic acid (355 Da, Ligand)
Nematostella vectensis TRPM2 tetramer in complex with ADPRP/Ca2+
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 9jje
Q-score: 0.488
Toth B, Jiang Y, Szollosi A, Zhang Z, Csanady L
PNAS (2024) 121 pp. e2415548121-e2415548121 [ DOI: doi:10.1073/pnas.2415548121 Pubmed: 39514307 ]
- Transient receptor potential cation channel subfamily m member-like 2 (176 kDa, Protein from Nematostella vectensis)
- Calcium ion (40 Da, Ligand)
- Nvtrpm2 tetramer in complex with adprp/ca2+ (700 kDa, Complex from Nematostella vectensis)
- [(2r,3r,4r,5r)-5-(6-amino-9h-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]methyl [(2r,3s,4r,5r)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (639 Da, Ligand)
Nematostella vectensis TRPM2 protomer in complex with ADPRP/Ca2+
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 9jjf
Q-score: 0.544
Toth B, Jiang Y, Szollosi A, Zhang Z, Csanady L
PNAS (2024) 121 pp. e2415548121-e2415548121 [ DOI: doi:10.1073/pnas.2415548121 Pubmed: 39514307 ]
- Transient receptor potential cation channel subfamily m member-like 2 (176 kDa, Protein from Nematostella vectensis)
- Calcium ion (40 Da, Ligand)
- [(2r,3r,4r,5r)-5-(6-amino-9h-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]methyl [(2r,3s,4r,5r)-3,4,5-trihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (639 Da, Ligand)
- Nvtrpm2 protomer in complex with adprp/ca2+ (170 kDa, Complex from Nematostella vectensis)
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Transient receptor potential cation channel subfamily m member 8 (Complex from Mus musculus)
- 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1h-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene (467 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Mus musculus)