Human TRPM2 ion channel in 1 mM ADPR
To Be Published
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Human trpm2 in 1 mm adpr (Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 2 (171 kDa, Protein from Homo sapiens)
Human TRPM2 ion channel in 1 mM dADPR
To Be Published
- [(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2r,3s,4r,5s)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate (559 Da, Ligand)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Human trpm2 in 1 mm adpr (Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 2 (171 kDa, Protein from Homo sapiens)
Human TRPM2 ion channel in 1 mM dADPR and Ca2+
To Be Published
- Zinc ion (65 Da, Ligand)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 2 (171 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Human trpm2 in 1 mm adpr (Complex from Homo sapiens)
- 2'-deoxyadenosine-5'-diphosphate (411 Da, Ligand)
Human TRPM2 ion channel in 1 mM BR-ADPR
To Be Published
- Human trpm2 in 1 mm br-adpr (Complex from Homo sapiens)
- (3r,4r,5r)-5-(6-amino-8-bromo-9h-purin-9-yl)-3,4,5-trihydroxypentyl [(2s,3s,4s,5r)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) (640 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 2 (171 kDa, Protein from Homo sapiens)
Human TRPM2 ion channel in 1 mM F-dADPR
To Be Published
- [(2r,3s,5r)-5-(6-amino-8-phenyl-9h-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2r,3s,4s,5r)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) (619 Da, Ligand)
- Human trpm2 in 1 mm f-dadpr (Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 2 (171 kDa, Protein from Homo sapiens)
MHR1/2 and NUDT9H of human TRPM2 in 1 mM dADPR (local refinement)
To Be Published
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Human trpm2 in 1 mm adpr (Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 2 (171 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Human TRPM2 ion channel in apo state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6mix
Q-score: -0.001
Human TRPM2 ion channel in an ADPR-bound state
Resolution: 6.1 Å
EM Method: Single-particle
Fitted PDBs: 6miz
Q-score: -0.002
Human TRPM2 ion channel in a calcium- and ADPR-bound state
Wang L, Fu TM, Zhou Y, Xia S, Greka A, Wu H
Science (2018) 362 [ DOI: doi:10.1126/science.aav4809 Pubmed: 30467180 ]
- Calcium ion (40 Da, Ligand)
- Human trpm2 ion channel (Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 2 (171 kDa, Protein from Homo sapiens)