Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 9b2a
Q-score: 0.34
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ Pubmed: 39809942 DOI: doi:10.1038/s41594-024-01463-8 ]
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Pregnenolone sulfate (396 Da, Ligand)
- (2s)-2-(3,4-dihydroquinolin-1(2h)-yl)-n-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide (347 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8rcr
Q-score: 0.329
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Cholesterol (386 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (83 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8rcu
Q-score: 0.325
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- 4-chloranyl-2-[2-(3-iodanylphenoxy)ethanoylamino]benzoic acid (431 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (83 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8rd9
Q-score: 0.2
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Cholesterol (386 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (84 kDa, Protein from Homo sapiens)
- 4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)benzoic acid (355 Da, Ligand)
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Transient receptor potential cation channel subfamily m member 8 (Complex from Mus musculus)
- 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1h-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene (467 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Mus musculus)
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Mus musculus)
- Transient receptor potential cation channel subfamily m member 8 (Complex from Mus musculus)
- N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-n-[(thiophen-2-yl)methyl]benzamide (394 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1h-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene (467 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Mus musculus)
- Transient receptor potential cation channel subfamily m member 8 (Complex from Mus musculus)
- Nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane (260 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014
Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY
Sci Adv (2024) 10 pp. eadp2211-eadp2211 [ DOI: doi:10.1126/sciadv.adp2211 Pubmed: 39093967 ]
- Transient receptor potential cation channel subfamily m member 8 (Complex from Parus major)
- 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1h-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene (467 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 8 (131 kDa, Protein from Parus major)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Human TRPM2 ion channel in 1 mM ADPR
To Be Published
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Human trpm2 in 1 mm adpr (Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 2 (171 kDa, Protein from Homo sapiens)
Human TRPM2 ion channel in 1 mM dADPR
To Be Published
- [(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2r,3s,4r,5s)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate (559 Da, Ligand)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Human trpm2 in 1 mm adpr (Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 2 (171 kDa, Protein from Homo sapiens)