Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8pwh
Q-score: 0.417
Ruedas R, Vuillemot R, Tubiana T, Winter JM, Pieri L, Arteni AA, Samson C, Jonic S, Mathieu M, Bressanelli S
J Struct Biol (2024) 216 pp. 108095-108095 [ DOI: doi:10.1016/j.jsb.2024.108095 Pubmed: 38723875 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ternary complex of her2-trastuzumab-pertuzumab fabs (171 kDa, Complex from Homo sapiens)
- Pertuzumab fab light chain (23 kDa, Protein from Homo sapiens)
- Trastuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Pertuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Trastuzumab fab light chain (23 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (68 kDa, Protein from Homo sapiens)
Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8q6j
Q-score: 0.364
Ruedas R, Vuillemot R, Tubiana T, Winter JM, Pieri L, Arteni AA, Samson C, Jonic S, Mathieu M, Bressanelli S
J Struct Biol (2024) 216 pp. 108095-108095 [ DOI: doi:10.1016/j.jsb.2024.108095 Pubmed: 38723875 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ternary complex of her2-trastuzumab-pertuzumab fabs (171 kDa, Complex from Homo sapiens)
- Pertuzumab fab light chain (23 kDa, Protein from Homo sapiens)
- Trastuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Pertuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (68 kDa, Protein from Homo sapiens)
- Trastuzumab fab light chain (23 kDa, Protein from Homo sapiens)
Ruedas R, Vuillemot R, Tubiana T, Winter JM, Pieri L, Arteni AA, Samson C, Jonic J, Mathieu M, Bressanelli S
To Be Published
Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7mn8
Q-score: 0.342
Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
Nature (2021) 600 pp. 339-343 [ DOI: doi:10.1038/s41586-021-04084-z Pubmed: 34759323 ]
- Her2-s310f-mbp fusion (Complex from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2,maltose/maltodextrin-binding periplasmic protein (160 kDa, Protein from Escherichia coli)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Receptor tyrosine-protein kinase erbb-3 (117 kDa, Protein from Homo sapiens)
- Trastuzumab fab heavy chain (25 kDa, Protein from Homo sapiens)
- Neuregulin-1b isoform 6 (Complex from Homo sapiens)
- Isoform 6 of pro-neuregulin-1, membrane-bound isoform (9 kDa, Protein from Homo sapiens)
- Trastuzumab (herceptin) fab (Complex from Homo sapiens)
- Nrg1b-bound her2/her3 heterodimer bound to the trastuzumab fab in the context of near full-length receptors (Complex)
- Trastuzumab fab light chain (24 kDa, Protein from Homo sapiens)
- Her3 (Complex from Homo sapiens)
Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex
Resolution: 4.36 Å
EM Method: Single-particle
Fitted PDBs: 6oge
Q-score: 0.3
Hao Y, Yu X, Bai Y, McBride HJ, Huang X
PLoS One (2019) 14 pp. e0216095-e0216095 [ Pubmed: 31042744 DOI: doi:10.1371/journal.pone.0216095 ]
- Trastuzumab fab light chain (23 kDa, Protein from Homo sapiens)
- Trastuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human her2 extracellular domain (Complex from Homo sapiens)
- Trastuzumab fab (Complex from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (68 kDa, Protein from Homo sapiens)
- Her2 extracellular domain-trastuzumab fab-pertuzumab fab complex (Complex from Homo sapiens)
- Pertuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Pertuzumab fab (Complex from Homo sapiens)
- Pertuzumab fab light chain (23 kDa, Protein from Homo sapiens)