Intact V-ATPase State 2 and synaptophysin complex in mouse brain isolated synaptic vesicles
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 9bra
Q-score: 0.284
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, Shen X, Held RG, Adams DJ, Basta T, Hampton L, Jian R, Jiang L, Stowell MHB, Baumeister W, Guo Q, Brunger AT
Nature (2024) 631 pp. 899-904 [ Pubmed: 38838737 DOI: doi:10.1038/s41586-024-07610-x ]
- V-type proton atpase subunit h (55 kDa, Protein from Mus musculus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Mus musculus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Mus musculus)
- Synaptophysin (34 kDa, Protein from Mus musculus)
- V-type proton atpase 116 kda subunit a 1 (96 kDa, Protein from Mus musculus)
- Mouse brain isolated glutamatergic synaptic vesicles (Cellular component from Mus musculus)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Mus musculus)
- V-type proton atpase 16 kda proteolipid subunit c (15 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Mus musculus)
- V-type proton atpase subunit f (13 kDa, Protein from Mus musculus)
- Ribonuclease kappa (11 kDa, Protein from Mus musculus)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Mus musculus)
- V-type proton atpase 21 kda proteolipid subunit c'' (21 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Mus musculus)
- V-type proton atpase subunit g 2 (13 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d (28 kDa, Protein from Mus musculus)
- Renin receptor cytoplasmic fragment (39 kDa, Protein from Mus musculus)
Intact V-ATPase State 3 and synaptophysin complex in mouse brain isolated synaptic vesicles
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 9brq
Q-score: 0.271
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, Shen X, Held RG, Adams DJ, Basta T, Hampton L, Jian R, Jiang L, Stowell MHB, Baumeister W, Guo Q, Brunger AT
Nature (2024) 631 pp. 899-904 [ Pubmed: 38838737 DOI: doi:10.1038/s41586-024-07610-x ]
- V-type proton atpase subunit f (13 kDa, Protein from Mus musculus)
- Mouse brain isolated glutamatergic synaptic vesicles (Cellular component from Mus musculus)
- V-type proton atpase 21 kda proteolipid subunit c'' (21 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Mus musculus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Mus musculus)
- V-type proton atpase 116 kda subunit a 1 (96 kDa, Protein from Mus musculus)
- Renin receptor cytoplasmic fragment (39 kDa, Protein from Mus musculus)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Mus musculus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Mus musculus)
- V-type proton atpase subunit g 2 (13 kDa, Protein from Mus musculus)
- Synaptophysin (34 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Mus musculus)
- V-type proton atpase 16 kda proteolipid subunit c (15 kDa, Protein from Mus musculus)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Mus musculus)
- Ribonuclease kappa (11 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d (28 kDa, Protein from Mus musculus)
- V-type proton atpase subunit h (55 kDa, Protein from Mus musculus)
Intact V-ATPase State 3 in synaptophysin knock-out isolated synaptic vesicles
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 9brr
Q-score: 0.3
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, Shen X, Held RG, Adams DJ, Basta T, Hampton L, Jian R, Jiang L, Stowell MHB, Baumeister W, Guo Q, Brunger AT
Nature (2024) 631 pp. 899-904 [ Pubmed: 38838737 DOI: doi:10.1038/s41586-024-07610-x ]
- V-type proton atpase subunit h (55 kDa, Protein from Mus musculus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Mus musculus)
- Renin receptor cytoplasmic fragment (39 kDa, Protein from Mus musculus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Mus musculus)
- V-type proton atpase 116 kda subunit a 1 (96 kDa, Protein from Mus musculus)
- V-type proton atpase 16 kda proteolipid subunit c (15 kDa, Protein from Mus musculus)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Mus musculus)
- Ribonuclease kappa (11 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Mus musculus)
- V-type proton atpase subunit f (13 kDa, Protein from Mus musculus)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Mus musculus)
- V-type proton atpase 21 kda proteolipid subunit c'' (21 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Mus musculus)
- V-type proton atpase subunit g 2 (13 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d (28 kDa, Protein from Mus musculus)
- Synaptophysin knock-out mouse brain isolated glutamatergic synaptic vesicles (Cellular component from Mus musculus)
Intact V-ATPase State 2 in synaptophysin knock-out isolated synaptic vesicles
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 9brs
Q-score: 0.277
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, Shen X, Held RG, Adams DJ, Basta T, Hampton L, Jian R, Jiang L, Stowell MHB, Baumeister W, Guo Q, Brunger AT
Nature (2024) 631 pp. 899-904 [ Pubmed: 38838737 DOI: doi:10.1038/s41586-024-07610-x ]
- V-type proton atpase subunit h (55 kDa, Protein from Mus musculus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Mus musculus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Mus musculus)
- V-type proton atpase 116 kda subunit a 1 (96 kDa, Protein from Mus musculus)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Mus musculus)
- Ribonuclease kappa (11 kDa, Protein from Mus musculus)
- V-type proton atpase 16 kda proteolipid subunit c (15 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Mus musculus)
- V-type proton atpase subunit f (13 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d (28 kDa, Protein from Mus musculus)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Mus musculus)
- V-type proton atpase 21 kda proteolipid subunit c'' (21 kDa, Protein from Mus musculus)
- Renin receptor cytoplasmic fragment (39 kDa, Protein from Mus musculus)
- V-type proton atpase subunit g 2 (13 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Mus musculus)
- Synaptophysin knock-out mouse brain isolated glutamatergic synaptic vesicles (Cellular component from Mus musculus)
Intact V-ATPase State 1 and synaptophysin complex in mouse brain isolated synaptic vesicles
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 9brt
Q-score: 0.271
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, Shen X, Held RG, Adams DJ, Basta T, Hampton L, Jian R, Jiang L, Stowell MHB, Baumeister W, Guo Q, Brunger AT
Nature (2024) 631 pp. 899-904 [ Pubmed: 38838737 DOI: doi:10.1038/s41586-024-07610-x ]
- V-type proton atpase subunit h (55 kDa, Protein from Mus musculus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Mus musculus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Mus musculus)
- Synaptophysin (34 kDa, Protein from Mus musculus)
- V-type proton atpase 116 kda subunit a 1 (96 kDa, Protein from Mus musculus)
- Mouse brain isolated glutamatergic synaptic vesicles (Cellular component from Mus musculus)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Mus musculus)
- V-type proton atpase 16 kda proteolipid subunit c (15 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Mus musculus)
- V-type proton atpase subunit f (13 kDa, Protein from Mus musculus)
- Ribonuclease kappa (11 kDa, Protein from Mus musculus)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Mus musculus)
- V-type proton atpase 21 kda proteolipid subunit c'' (21 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Mus musculus)
- V-type proton atpase subunit g 2 (13 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d (28 kDa, Protein from Mus musculus)
- Renin receptor cytoplasmic fragment (39 kDa, Protein from Mus musculus)
Intact V-ATPase State 1 in synaptophysin knock-out isolated synaptic vesicles
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 9bru
Q-score: 0.262
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, Shen X, Held RG, Adams DJ, Basta T, Hampton L, Jian R, Jiang L, Stowell MHB, Baumeister W, Guo Q, Brunger AT
Nature (2024) 631 pp. 899-904 [ Pubmed: 38838737 DOI: doi:10.1038/s41586-024-07610-x ]
- V-type proton atpase subunit h (55 kDa, Protein from Mus musculus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Mus musculus)
- Renin receptor cytoplasmic fragment (39 kDa, Protein from Mus musculus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Mus musculus)
- V-type proton atpase 116 kda subunit a 1 (96 kDa, Protein from Mus musculus)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Mus musculus)
- Ribonuclease kappa (11 kDa, Protein from Mus musculus)
- V-type proton atpase 16 kda proteolipid subunit c (15 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Mus musculus)
- V-type proton atpase subunit f (13 kDa, Protein from Mus musculus)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Mus musculus)
- V-type proton atpase 21 kda proteolipid subunit c'' (21 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Mus musculus)
- V-type proton atpase subunit g 2 (13 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d (28 kDa, Protein from Mus musculus)
- Synaptophysin knock-out mouse brain isolated glutamatergic synaptic vesicles (Cellular component from Mus musculus)
V0-only V-ATPase in synaptophysin gene knock-out mouse brain isolated synaptic vesicles
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9bry
Q-score: 0.373
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, Shen X, Held RG, Adams DJ, Basta T, Hampton L, Jian R, Jiang L, Stowell MHB, Baumeister W, Guo Q, Brunger AT
Nature (2024) 631 pp. 899-904 [ Pubmed: 38838737 DOI: doi:10.1038/s41586-024-07610-x ]
- V-type proton atpase 21 kda proteolipid subunit c'' (21 kDa, Protein from Mus musculus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Mus musculus)
- V-type proton atpase 116 kda subunit a 1 (96 kDa, Protein from Mus musculus)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Mus musculus)
- V-type proton atpase 16 kda proteolipid subunit c (15 kDa, Protein from Mus musculus)
- Renin receptor cytoplasmic fragment (32 kDa, Protein from Mus musculus)
- Beta-d-mannopyranose (180 Da, Ligand)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Mus musculus)
- Ribonuclease kappa (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Syptophysin gene knock-out mouse brain isolated glutamatergic synaptic vesicles (Cellular component from Mus musculus)
V0-only V-ATPase and synaptophysin complex in mouse brain isolated synaptic vesicles
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9brz
Q-score: 0.385
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, Shen X, Held RG, Adams DJ, Basta T, Hampton L, Jian R, Jiang L, Stowell MHB, Baumeister W, Guo Q, Brunger AT
Nature (2024) 631 pp. 899-904 [ Pubmed: 38838737 DOI: doi:10.1038/s41586-024-07610-x ]
- V-type proton atpase subunit s1 (51 kDa, Protein from Mus musculus)
- Ribonuclease kappa (11 kDa, Protein from Mus musculus)
- Mouse brain isolated glutamatergic synaptic vesicles (Cellular component from Mus musculus)
- V-type proton atpase 16 kda proteolipid subunit c (15 kDa, Protein from Mus musculus)
- V-type proton atpase 116 kda subunit a 1 (96 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Mus musculus)
- V-type proton atpase 21 kda proteolipid subunit c'' (21 kDa, Protein from Mus musculus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Mus musculus)
- Synaptophysin (34 kDa, Protein from Mus musculus)
- Renin receptor cytoplasmic fragment (39 kDa, Protein from Mus musculus)
Human V-ATPase in state 2 with SidK and mEAK-7
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7u4t
Q-score: 0.331
Wang L, Wu D, Robinson CV, Fu TM
PNAS (2022) 119 pp. e2203742119-e2203742119 [ Pubmed: 35994636 DOI: doi:10.1073/pnas.2203742119 ]
- V-type proton atpase subunit g 1 (13 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Homo sapiens)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Homo sapiens)
- Renin receptor (39 kDa, Protein from Homo sapiens)
- Ribonuclease kappa (15 kDa, Protein from Homo sapiens)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Homo sapiens)
- V-type proton atpase 116 kda subunit a isoform 1 (96 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V-type proton atpase subunit s1 (52 kDa, Protein from Homo sapiens)
- V-atpase with sidk and meak-7 (Complex from Homo sapiens)
- V-type proton atpase subunit f (13 kDa, Protein from Homo sapiens)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Homo sapiens)
- Mtor-associated protein meak7 (51 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- V-type proton atpase subunit d (28 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit e 1 (9 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit h (55 kDa, Protein from Homo sapiens)
- Sidk (65 kDa, Protein from Legionella pneumophila)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Homo sapiens)
CryoEM structure of a mEAK7 bound human V-ATPase complex
Resolution: 4.08 Å
EM Method: Single-particle
Fitted PDBs: 7unf
Q-score: 0.479
Nat Commun (2022) 13 pp. 3272-3272 [ DOI: doi:10.1038/s41467-022-30899-z Pubmed: 35672408 ]
- V-type proton atpase subunit g 1 (13 kDa, Protein from Homo sapiens)
- Ribonuclease kappa (15 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Homo sapiens)
- Cryoem structure of meak7 bound human v-atpase complex (Complex from Homo sapiens)
- V-type proton atpase 116 kda subunit a 4 (98 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit d (28 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit s1 (52 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Homo sapiens)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit f (13 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit h (55 kDa, Protein from Homo sapiens)
- Atpase h(+)-transporting lysosomal accessory protein 2 (38 kDa, Protein from Homo sapiens)
- Kiaa1609 protein, isoform cra_a (51 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- V-type proton atpase subunit e 1 (9 kDa, Protein from Homo sapiens)