Cryo-EM structure of human VMAT2 in complex with serotonin.
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8x3k
Q-score: 0.553
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ DOI: doi:10.1038/s41467-024-55361-0 Pubmed: 39747030 ]
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Vmat2 (Complex from Homo sapiens)
Cryo-EM structure of human VMAT2 in complex with valbenazine
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 9kq8
Q-score: 0.495
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ DOI: doi:10.1038/s41467-024-55361-0 Pubmed: 39747030 ]
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Valbenazine (418 Da, Ligand)
- Vmat2 (Complex from Homo sapiens)
Cryo-EM structure of human VMAT2 in complex with Tetrabenazine
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 9kqa
Q-score: 0.462
Cryo-EM structure of human VMAT2 in complex with dopamine.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9kqe
Q-score: 0.516
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ DOI: doi:10.1038/s41467-024-55361-0 Pubmed: 39747030 ]
- L-dopamine (153 Da, Ligand)
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Vmat2 (Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ucj
Q-score: 0.507
To Be Published
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Cytochrome c oxidase subunit 4 (16 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Komagataella pastoris cytochrome c oxidase (11 subunits) in complex with human vmat2 (246 kDa, Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Cytochrome c oxidase subunit 13 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 12 (8 kDa, Protein from Komagataella pastoris)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
Komagataella pastoris Cytochrome c oxidase (9 subunits) in complex with human VMAT2
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8uck
Q-score: 0.486
To Be Published
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Komagataella pastoris cytochrome c oxidase (9 subunits) in complex with human vmat2 (225 kDa, Complex from Homo sapiens)
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Phosphatidylethanolamine (734 Da, Ligand)
Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Tetrabenazine
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8ucl
Q-score: 0.511
To Be Published
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Copper (ii) ion (63 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (3s,5r,11bs)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-one (317 Da, Ligand)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase-vmat2-tetrabenazine particle (225 kDa, Complex from Homo sapiens)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Phosphatidylethanolamine (734 Da, Ligand)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Reserpine
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8ucm
Q-score: 0.513
To Be Published
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Reserpine (608 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase-vmat2-reserpine particle (225 kDa, Complex from Homo sapiens)
Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Histamine
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8ucn
Q-score: 0.486
To Be Published
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Komagataella pastoris cytochrome c oxidase in complex with human vmat2 and histamine (225 kDa, Complex from Homo sapiens)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Histamine (111 Da, Ligand)
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Phosphatidylethanolamine (734 Da, Ligand)
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8uco
Q-score: 0.484
To Be Published
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Komagataella pastoris cytochrome c oxidase in complex with human vmat2 and amphetamin (225 kDa, Complex from Homo sapiens)
- (2s)-1-phenylpropan-2-amine (135 Da, Ligand)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Phosphatidylethanolamine (734 Da, Ligand)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)