Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8cx0
Q-score: 0.509
Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD
Nature (2023) 615 pp. 728-733 [ Pubmed: 36754086 DOI: doi:10.1038/s41586-023-05779-1 ]
- Rna (5'-r(p*ap*ap*ap*ap*ap*ap*ap*a)-3') (2 kDa, RNA from Spodoptera frugiperda)
- Virion infectivity factor (22 kDa, Protein from Human immunodeficiency virus 1)
- Dna dc->du-editing enzyme apobec-3g (50 kDa, Protein from Homo sapiens)
- Hiv-1 vif-e3 ligase substrate receptor (vcbc) in complex with human apobec3g and rna (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Core-binding factor subunit beta (21 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8cx1
Q-score: 0.366
Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD
Nature (2023) 615 pp. 728-733 [ Pubmed: 36754086 DOI: doi:10.1038/s41586-023-05779-1 ]
- Virion infectivity factor (22 kDa, Protein from Human immunodeficiency virus 1)
- Dna dc->du-editing enzyme apobec-3g (50 kDa, Protein from Homo sapiens)
- Hiv-1 vif-e3 ligase substrate receptor (vcbc) in complex with human apobec3g and rna (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Core-binding factor subunit beta (21 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*ap*ap*ap*ap*up*ap*up*u)-3') (2 kDa, RNA from Spodoptera frugiperda)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*up*ap*ap*ap*up*ap*up*u)-3') (2 kDa, RNA from Spodoptera frugiperda)
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8cx2
Q-score: 0.375
Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD
Nature (2023) 615 pp. 728-733 [ Pubmed: 36754086 DOI: doi:10.1038/s41586-023-05779-1 ]
- Virion infectivity factor (22 kDa, Protein from Human immunodeficiency virus 1)
- Dna dc->du-editing enzyme apobec-3g (50 kDa, Protein from Homo sapiens)
- Hiv-1 vif-e3 ligase substrate receptor (vcbc) in complex with human apobec3g and rna (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Core-binding factor subunit beta (21 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*ap*ap*up*ap*ap*ap*ap*ap*u)-3') (2 kDa, RNA from Spodoptera frugiperda)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Rna (5'-r(p*up*up*up*ap*ap*ap*ap*ap*u)-3') (2 kDa, RNA from Spodoptera frugiperda)
Maedi visna virus Vif in complex with CypA and E3 ubiquitin ligase
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7upn
Q-score: 0.402
Hu Y, Gudnadottir RB, Knecht KM, Arizaga F, Jonsson SR, Xiong Y
Sci Adv (2023) 9 pp. eadd3422-eadd3422 [ Pubmed: 36638173 DOI: doi:10.1126/sciadv.add3422 ]
- Peptidyl-prolyl cis-trans isomerase a (18 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Virion infectivity factor (28 kDa, Protein from Visna-maedi virus)
- Maedi visna virus vif in complex with human cypa and elongin bc components of e3 ubiquitin ligase (Complex from Homo sapiens)
Full-length APOBEC3G in complex with HIV-1 Vif, CBF-beta, and fork RNA
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8e40
Q-score: 0.343
Ito F, Alvarez-Cabrera AL, Liu S, Yang H, Shiriaeva A, Zhou ZH, Chen XS
Sci Adv (2023) 9 pp. eade3168-eade3168 [ Pubmed: 36598981 DOI: doi:10.1126/sciadv.ade3168 ]
- Virion infectivity factor (21 kDa, Protein from Human immunodeficiency virus 1)
- Rna (8 kDa, RNA from Escherichia coli)
- Dna dc->du-editing enzyme apobec-3g (45 kDa, Protein from Macaca mulatta)
- Zinc ion (65 Da, Ligand)
- Complex of apobec3g with hiv-1 vif and cbf-beta bound to fork rna (99 kDa, Complex from Human immunodeficiency virus 1)
- Rna (6 kDa, RNA from Escherichia coli)
- Core-binding factor subunit beta (18 kDa, Protein from Homo sapiens)
cryoEM structure of the truncated HIV-1 Vif/CBFbeta/A3F complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6nil
Q-score: 0.383
Hu Y, Desimmie BA, Nguyen HC, Ziegler SJ, Cheng TC, Chen J, Wang J, Wang H, Zhang K, Pathak VK, Xiong Y
Nat Struct Mol Biol (2019) 26 pp. 1176-1183 [ Pubmed: 31792451 DOI: doi:10.1038/s41594-019-0343-6 ]
- Core-binding factor subunit beta (17 kDa, Protein from Homo sapiens)
- Dna dc->du-editing enzyme apobec-3f (24 kDa, Protein from Homo sapiens)
- Virion infectivity factor (16 kDa, Protein from Human immunodeficiency virus 1)
- Zinc ion (65 Da, Ligand)
- 6xhis tagged ha3fctd-40aa-hcbfbeta fusion (Complex from Homo sapiens)
- Truncated vif/cbfbeta/a3fctd complex (17 kDa, Complex from Human immunodeficiency virus 1)
- Alpha domain truncated hiv-1 vif (Complex from Human immunodeficiency virus 1)