Structure of FFAR1-Gq complex bound to DHA
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8eit
Q-score: 0.529
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM
PNAS (2023) 120 pp. e2219569120-e2219569120 [ DOI: doi:10.1073/pnas.2219569120 Pubmed: 37216523 ]
- Free fatty acid receptor1- g-protein complex (Complex from Homo sapiens)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Docosa-4,7,10,13,16,19-hexaenoic acid (328 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
Structure of FFAR1-Gq complex bound to TAK-875
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ejc
Q-score: 0.522
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM
PNAS (2023) 120 pp. e2219569120-e2219569120 [ DOI: doi:10.1073/pnas.2219569120 Pubmed: 37216523 ]
- Free fatty acid receptor1- g-protein complex (Complex from Homo sapiens)
- [(3s)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid (524 Da, Ligand)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ejk
Q-score: 0.488
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM
PNAS (2023) 120 pp. e2219569120-e2219569120 [ DOI: doi:10.1073/pnas.2219569120 Pubmed: 37216523 ]
- Free fatty acid receptor1- g-protein complex (Complex from Homo sapiens)
- [(3s)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid (524 Da, Ligand)
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
Molecular mechanism of the the wake-promoting agent TAK-925
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7sr8
Q-score: 0.457
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM
Nat Commun (2022) 13 pp. 2902-2902 [ Pubmed: 35614071 DOI: doi:10.1038/s41467-022-30601-3 ]
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- Human orexin receptor 2 - g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Hypocretin receptor type 2 (46 kDa, Protein from Homo sapiens)
- Methyl (2r,3s)-3-[(methanesulfonyl)amino]-2-({[(1s,4s)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)