Human ACKR3 phosphorylated by GRK2 in complex with Arrestin2 in nanodisc
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8tii
Q-score: 0.481
To Be Published
- Human ackr3 phosphorylated by grk2 in complex with arrestin2 in nanodisc (Complex from Bos taurus)
- Anti-fab nanobody (13 kDa, Protein from synthetic construct)
- Fab7 light chain (23 kDa, Protein from synthetic construct)
- Atypical chemokine receptor 3 (45 kDa, Protein from Homo sapiens)
- Fab7 heavy chain (25 kDa, Protein from synthetic construct)
- Beta-arrestin-1 (47 kDa, Protein from Bos taurus)
Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 9iya
Q-score: 0.415
Chang H, Li X, Shen L, Ge X, Hao S, Wu L, Liu S, Liu J, Cherezov V, Hua T
Cell Res (2025) 35 pp. 80-83 [ Pubmed: 39482405 DOI: doi:10.1038/s41422-024-01046-8 ]
- G-protein coupled receptor 55,soluble cytochrome b562 (47 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (13 kDa, Protein from Homo sapiens)
- 4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{n}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{h}-quinoline-3-carboxamide (527 Da, Ligand)
- Ternary complex of gpr55 with anti-bril fab and anti-fab nanobody (173 kDa, Complex from Homo sapiens)
- Anti-bril fab heavy chain (26 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (23 kDa, Protein from Homo sapiens)
Structure of interleukin receptor common gamma chain (IL2Rgamma/CD132) in complex with 2D4
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9jqt
Q-score: 0.555
Yin H, Li L, Feng X, Wang Z, Zheng M, Zhao J, Fan X, Wu W, Gao L, Zhan Y, Zhao M, Lu Q
Signal Transduct Target Ther (2024) 9 pp. 323-323 [ Pubmed: 39551768 DOI: doi:10.1038/s41392-024-02017-6 ]
- 2d4-light chain (23 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- Interleukin receptor common gamma chain (il2rgamma/cd132) in complex with 2d4 (Complex from Homo sapiens)
- Cytokine receptor common subunit gamma (28 kDa, Protein from Homo sapiens)
- 2d4-heavy chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of ETAR bound with Macitentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ Pubmed: 39075075 DOI: doi:10.1038/s41421-024-00705-9 ]
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Complex of endothelin receptor type a with macitentan (Complex from Homo sapiens)
- Macitentan (588 Da, Ligand)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
Cryo-EM structure of ETAR bound with Ambrisentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Ambrisentan (378 Da, Ligand)
- Complex of endothelin receptor type a with ambrisentan (Complex from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of ETAR bound with Zibotentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ Pubmed: 39075075 DOI: doi:10.1038/s41421-024-00705-9 ]
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- Complex of endothelin receptor type a with zibotentan (Complex from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Zibotentan (424 Da, Ligand)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 9cmi
Q-score: 0.468
Rathnayake SS, Erramilli SK, Kossiakoff AA, Vecchio AJ
Structure (2024) 32 pp. 1936- [ Pubmed: 39383874 DOI: doi:10.1016/j.str.2024.09.015 ]
- Water (18 Da, Ligand)
- Heat-labile enterotoxin b chain (33 kDa, Protein from Clostridium perfringens)
- Cop-1 sfab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (13 kDa, Protein from Homo sapiens)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Human claudin-4 complex with clostridium perfringens enterotoxin, sfab cop-1, and nanobody (120 kDa, Complex from synthetic construct)
- Cop-1 sfab light chain (25 kDa, Protein from Homo sapiens)
- Claudin-4 (22 kDa, Protein from Homo sapiens)
Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8th3
Q-score: 0.532
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ DOI: doi:10.1038/s41589-024-01620-6 Pubmed: 38744986 ]
- At118-h nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion, anti-bril fab, and anti-fab nanobody (Complex from Homo sapiens)
- At118-h nanobody, type-1 angiotensin ii receptor, soluble cytochrome b562 complex (65 kDa, Protein from Homo sapiens)
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8th4
Q-score: 0.495
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ DOI: doi:10.1038/s41589-024-01620-6 Pubmed: 38744986 ]
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
- [2-butyl-5-chloranyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol (422 Da, Ligand)
- At118-l nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion protein, anti-bril fab, anti-fab nanobody, and losartan (Complex from Homo sapiens)
- At118-l nanobody (15 kDa, Protein from synthetic construct)
- Type-1 angiotensin ii receptor soluble cytochrome b562 complex (49 kDa, Protein from Homo sapiens)
ZIKV rsNS1 in complex with Fab AA12 and anti-fab nanobody
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8wnp
Q-score: 0.428
Chew BLA, Ngoh AQ, Phoo WW, Weng MJG, Sheng HJ, Chan KWK, Tan EYJ, Gelbart T, Xu C, Tan GS, Vasudevan SG, Luo D
Npj Viruses (2024) 2 pp. 14- [ DOI: doi:10.1038/s44298-024-00024-6 ]
- Anti-fab nanobody (13 kDa, Protein from Lama glama)
- Zikv rsns1 in complex with fab aa12 and anti-fab nanobody (Complex from Zika virus)
- Vl chains (23 kDa, Protein from Homo sapiens)
- Vh chains (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)