Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 9iya
Q-score: 0.415
Chang H, Li X, Shen L, Ge X, Hao S, Wu L, Liu S, Liu J, Cherezov V, Hua T
Cell Res (2025) 35 pp. 80-83 [ Pubmed: 39482405 DOI: doi:10.1038/s41422-024-01046-8 ]
- Anti-bril fab heavy chain (26 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 55,soluble cytochrome b562 (47 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (23 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (13 kDa, Protein from Homo sapiens)
- Ternary complex of gpr55 with anti-bril fab and anti-fab nanobody (173 kDa, Complex from Homo sapiens)
- 4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{n}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{h}-quinoline-3-carboxamide (527 Da, Ligand)
Cryo-EM structure of ETAR bound with Macitentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Macitentan (588 Da, Ligand)
- Complex of endothelin receptor type a with macitentan (Complex from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
Cryo-EM structure of ETAR bound with Ambrisentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Complex of endothelin receptor type a with ambrisentan (Complex from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Ambrisentan (378 Da, Ligand)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
Cryo-EM structure of ETAR bound with Zibotentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Complex of endothelin receptor type a with zibotentan (Complex from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- Zibotentan (424 Da, Ligand)
Cryo-EM structure of GSK682753A-bound EBI2/GPR183
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7tuy
Q-score: 0.471
Structure (2022) 30 pp. 1016- [ Pubmed: 35537452 DOI: doi:10.1016/j.str.2022.04.006 ]
- 8-[(2e)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one (479 Da, Ligand)
- Complex of gsk682753a-bound ebi2/gpr183-bril chimera with anti-bril fab and anti-fab nanobody (Complex)
- Anti-bril fab light chain (23 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (24 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (Complex from synthetic construct)
- Anti-bril fab heavy chain, anti-bril fab light chain (Complex from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- G-protein coupled receptor 183,soluble cytochrome b562 fusion (54 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 183,soluble cytochrome b562 fusion (Complex from Homo sapiens)