Structure of interleukin receptor common gamma chain (IL2Rgamma/CD132) in complex with 2D4
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9jqt
Q-score: 0.555
Yin H, Li L, Feng X, Wang Z, Zheng M, Zhao J, Fan X, Wu W, Gao L, Zhan Y, Zhao M, Lu Q
Signal Transduct Target Ther (2024) 9 pp. 323-323 [ DOI: doi:10.1038/s41392-024-02017-6 Pubmed: 39551768 ]
- Cytokine receptor common subunit gamma (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- 2d4-light chain (23 kDa, Protein from Homo sapiens)
- Interleukin receptor common gamma chain (il2rgamma/cd132) in complex with 2d4 (Complex from Homo sapiens)
- 2d4-heavy chain (23 kDa, Protein from Homo sapiens)
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 9bei
Q-score: 0.276
Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, Rosset S, Kapoor S, Choudhury J, Dauparas J, Schellhaas C, Kozlov S, Baker D, Ovchinnikov S, Vecchio AJ, Correia BE
Nature (2024) 631 pp. 449-458 [ DOI: doi:10.1038/s41586-024-07601-y Pubmed: 38898281 ]
- Cop-2 fab light chain (23 kDa, Protein from Escherichia coli)
- Claudin-4 (22 kDa, Protein from Homo sapiens)
- Synthetic human claudin-4 complex with clostridium perfringens enterotoxin c-terminal domain, sfab cop-2, and nanobody against cop-2 (103 kDa, Complex from Homo sapiens)
- Cop-2 fab heavy chain (25 kDa, Protein from Escherichia coli)
- Heat-labile enterotoxin b chain (14 kDa, Protein from Clostridium perfringens)
- Anti-fab nanobody (13 kDa, Protein from Escherichia coli)
Structure of the mu opioid receptor bound to the antagonist nanobody NbE
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8qot
Q-score: 0.413
Yu J, Kumar A, Zhang X, Martin C, Van Holsbeeck K, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M
Nat Commun (2024) 15 pp. 8687-8687 [ Pubmed: 39384768 DOI: doi:10.1038/s41467-024-52947-6 ]
- Nabfab hc (28 kDa, Protein from synthetic construct)
- Anti-fab nanobody (17 kDa, Protein from Lama glama)
- Nanobody e (nbe) (18 kDa, Protein from Lama glama)
- Mor-nbe-nabfab-antifab complex (120 kDa, Complex from Mus musculus)
- Mu-type opioid receptor (53 kDa, Protein from Mus musculus)
- Nabfab lc (25 kDa, Protein from synthetic construct)
Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7sk5
Q-score: 0.438
Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM
Sci Adv (2022) 8 pp. eabn8063-eabn8063 [ Pubmed: 35857509 DOI: doi:10.1126/sciadv.abn8063 ]
- Atypical chemokine receptor 3 (45 kDa, Protein from Homo sapiens)
- Stromal cell-derived factor 1 (7 kDa, Protein from Homo sapiens)
- Cid24 fab light chain (23 kDa, Protein from Homo sapiens)
- Cid24 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (13 kDa, Protein from Lama glama)
- Complex structure of ackr3-cxcl12-cid24-nb (Complex)
- Cholesterol (386 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7sk7
Q-score: 0.514
Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM
Sci Adv (2022) 8 pp. eabn8063-eabn8063 [ Pubmed: 35857509 DOI: doi:10.1126/sciadv.abn8063 ]
- Atypical chemokine receptor 3 (45 kDa, Protein from Homo sapiens)
- Stromal cell-derived factor 1 (7 kDa, Protein from Homo sapiens)
- (1r)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium (540 Da, Ligand)
- Cid25 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Complex structure of nb-cid25-ackr3-cxcl12-ccx662 (Complex)
- Cid25 fab light chain (23 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (13 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 7php
Q-score: 0.505
Bloch JS, Mukherjee S, Kowal J, Filippova EV, Niederer M, Pardon E, Steyaert J, Kossiakoff AA, Locher KP
PNAS (2021) 118 [ Pubmed: 34782475 DOI: doi:10.1073/pnas.2115435118 ]
- Water (18 Da, Ligand)
- Complex of vibrio cholerae mate transporter norm, chimeric nanobody norm-nb17_4, nabfab, and anti-fab nanobody (Complex from Vibrio cholerae RC385)
- Nabfab lc (23 kDa, Protein from synthetic construct)
- Norm-nb17_4 (14 kDa, Protein from synthetic construct)
- Anti-fab nanobody (13 kDa, Protein from Lama glama)
- Nabfab hc (25 kDa, Protein from synthetic construct)
- Multidrug resistance protein norm (52 kDa, Protein from Vibrio cholerae RC385)
Bloch JS, Mukherjee S, Kowal J, Filippova EV, Niederer M, Pardon E, Steyaert J, Kossiakoff AA, Locher KP
PNAS (2021) 118 [ Pubmed: 34782475 DOI: doi:10.1073/pnas.2115435118 ]
- Anti-fab nanobody (Complex)
- Complex of vibrio cholerae mate transporter norm, chimeric nanobody norm-nb17_4, nabfab, and anti-fab nanobody (Complex from Vibrio cholerae RC385)
- Nabfab hc (Complex from synthetic construct)
- Nabfab lc (Complex from synthetic construct)
- Multidrug resistance protein norm (Complex from synthetic construct)
- Norm-nb17_4 (Complex from Lama glama)
Resolution: 8.45 Å
EM Method: Single-particle
Fitted PDBs: 7phq
Q-score: 0.111
Bloch JS, Mukherjee S, Kowal J, Filippova EV, Niederer M, Pardon E, Steyaert J, Kossiakoff AA, Locher KP
PNAS (2021) 118 [ Pubmed: 34782475 DOI: doi:10.1073/pnas.2115435118 ]
- Water (18 Da, Ligand)
- Complex of staphylococcus capitis divalent metal ion transporter (dmt), chimeric nanobody dmtnb16_4, nabfab, and anti-fab nanobody (Complex from synthetic construct)
- Dmt-nb16_4 (14 kDa, Protein from synthetic construct)
- Nabfab lc (23 kDa, Protein from synthetic construct)
- Divalent metal cation transporter mnth (47 kDa, Protein from Staphylococcus capitis)
- Anti-fab nanobody (13 kDa, Protein from Lama glama)
- Nabfab hc (25 kDa, Protein from synthetic construct)
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 7pij
Q-score: 0.422
Bloch JS, Mukherjee S, Kowal J, Filippova EV, Niederer M, Pardon E, Steyaert J, Kossiakoff AA, Locher KP
PNAS (2021) 118 [ Pubmed: 34782475 DOI: doi:10.1073/pnas.2115435118 ]
- Water (18 Da, Ligand)
- Complex of staphylococcus capitis divalent metal ion transporter (dmt), chimeric nanobody dmtnb16_4, nabfab, and anti-fab nanobody (Complex from synthetic construct)
- Nabfab lc (23 kDa, Protein from synthetic construct)
- Divalent metal cation transporter mnth (47 kDa, Protein from Staphylococcus capitis)
- Anti-fab nanobody (13 kDa, Protein from Lama glama)
- Nabfab hc (25 kDa, Protein from synthetic construct)
- Dmtnb16_4 (14 kDa, Protein from synthetic construct)