Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8top
Q-score: 0.391
Wang H, Cheng C, Dal Santo JL, Shen CH, Bylund T, Henry AR, Howe CA, Hwang J, Morano NC, Morris DJ, Pletnev S, Roark RS, Zhou T, Hansen BT, Hoyt FH, Johnston TS, Wang S, Zhang B, Ambrozak DR, Becker JE, Bender MF, Changela A, Chaudhary R, Corcoran M, Corrigan AR, Foulds KE, Guo Y, Lee M, Li Y, Lin BC, Liu T, Louder MK, Mandolesi M, Mason RD, McKee K, Nair V, O'Dell S, Olia AS, Ou L, Pegu A, Raju N, Rawi R, Roberts-Torres J, Sarfo EK, Sastry M, Schaub AJ, Schmidt SD, Schramm CA, Schwartz CL, Smith SC, Stephens T, Stuckey J, Teng IT, Todd JP, Tsybovsky Y, Van Wazer DJ, Wang S, Doria-Rose NA, Fischer ER, Georgiev IS, Karlsson Hedestam GB, Sheng Z, Woodward RA, Douek DC, Koup RA, Pierson TC, Shapiro L, Shaw GM, Mascola JR, Kwong PD
Cell (2024) 187 pp. 7214-7231.e23 [ Pubmed: 39471811 DOI: doi:10.1016/j.cell.2024.10.003 ]
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Heavy chain of antibody gpz6-b.01 (25 kDa, Protein from Macaca mulatta)
- Complex between hiv-1 env bg505 ds-sosip and antibody gpz6-b.01 (720 kDa, Complex from Homo sapiens)
- Light chain of antibody gpz6-b.01 (23 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8tjr
Q-score: 0.49
Wang H, Cheng C, Dal Santo JL, Shen CH, Bylund T, Henry AR, Howe CA, Hwang J, Morano NC, Morris DJ, Pletnev S, Roark RS, Zhou T, Hansen BT, Hoyt FH, Johnston TS, Wang S, Zhang B, Ambrozak DR, Becker JE, Bender MF, Changela A, Chaudhary R, Corcoran M, Corrigan AR, Foulds KE, Guo Y, Lee M, Li Y, Lin BC, Liu T, Louder MK, Mandolesi M, Mason RD, McKee K, Nair V, O'Dell S, Olia AS, Ou L, Pegu A, Raju N, Rawi R, Roberts-Torres J, Sarfo EK, Sastry M, Schaub AJ, Schmidt SD, Schramm CA, Schwartz CL, Smith SC, Stephens T, Stuckey J, Teng IT, Todd JP, Tsybovsky Y, Van Wazer DJ, Wang S, Doria-Rose NA, Fischer ER, Georgiev IS, Karlsson Hedestam GB, Sheng Z, Woodward RA, Douek DC, Koup RA, Pierson TC, Shapiro L, Shaw GM, Mascola JR, Kwong PD
Cell (2024) 187 pp. 7214-7231.e23 [ Pubmed: 39471811 DOI: doi:10.1016/j.cell.2024.10.003 ]
- Cryo-em structure of hiv-1 bg505ds-sosip.664 env trimer bound to herh-c.01 fab (Complex from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Antibody herh-a.01 light chain (12 kDa, Protein from Macaca)
- Antibody herh-a.01 heavy chain (12 kDa, Protein from Macaca)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO GPZ6-a.01 FAB
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8tjs
Q-score: 0.461
Wang H, Cheng C, Dal Santo JL, Shen CH, Bylund T, Henry AR, Howe CA, Hwang J, Morano NC, Morris DJ, Pletnev S, Roark RS, Zhou T, Hansen BT, Hoyt FH, Johnston TS, Wang S, Zhang B, Ambrozak DR, Becker JE, Bender MF, Changela A, Chaudhary R, Corcoran M, Corrigan AR, Foulds KE, Guo Y, Lee M, Li Y, Lin BC, Liu T, Louder MK, Mandolesi M, Mason RD, McKee K, Nair V, O'Dell S, Olia AS, Ou L, Pegu A, Raju N, Rawi R, Roberts-Torres J, Sarfo EK, Sastry M, Schaub AJ, Schmidt SD, Schramm CA, Schwartz CL, Smith SC, Stephens T, Stuckey J, Teng IT, Todd JP, Tsybovsky Y, Van Wazer DJ, Wang S, Doria-Rose NA, Fischer ER, Georgiev IS, Karlsson Hedestam GB, Sheng Z, Woodward RA, Douek DC, Koup RA, Pierson TC, Shapiro L, Shaw GM, Mascola JR, Kwong PD
Cell (2024) 187 pp. 7214-7231.e23 [ Pubmed: 39471811 DOI: doi:10.1016/j.cell.2024.10.003 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Antibody gpz6-a.01 heavy chain (13 kDa, Protein from Macaca)
- Antibody gpz6-a.01 light chain (11 kDa, Protein from Macaca)
- Cryo-em structure of vaccine-elicited antibody gpz6-a.01 in complex with hiv-1 env bg505 ds-sosip (Complex from Homo sapiens)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody FP3
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8t2e
Q-score: 0.48
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Fp3 heavy chain (11 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Fp3 heavy chain, fp3 light chain (Complex from Macaca mulatta)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Bg505 boost 2 in complex with nhp polyclonal antibody fp3 (470 kDa, Complex)
- Fp3 light chain (8 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody N289
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8t2f
Q-score: 0.424
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- N289 heavy chain, n289 light chain (Complex from Macaca mulatta)
- N289 light chain (8 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Bg505 boost 2 in complex with nhp polyclonal antibody n289 (470 kDa, Complex)
- N289 heavy chain (9 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody IF1
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8swv
Q-score: 0.506
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- If1 heavy chain (10 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- If1 heavy chain, if1 light chain (Complex from Macaca mulatta)
- Bg505 boost 2 in complex with nhp polyclonal antibody if1 (470 kDa, Complex)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- If1 light chain (8 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody IF3
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8sww
Q-score: 0.471
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 boost 2 in complex with nhp polyclonal antibody if3 (470 kDa, Complex)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Nhp polyclonal antibody if3 heavy chain, nhp polyclonal antibody if3 light chain (Complex from Macaca mulatta)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Nhp polyclonal antibody if3 light chain (9 kDa, Protein from Macaca mulatta)
- Nhp polyclonal antibody if3 heavy chain (9 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody Base4
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8swx
Q-score: 0.43
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Base4 heavy chain (9 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Base4 light chain (7 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Base4 heavy chain, base4 light chain (Complex from Macaca mulatta)
- Bg505 boost 2 in complex with nhp polyclonal antibody base4 (470 kDa, Complex)
Cryo-EM structure of Antibody SKW11 in complex with Western Equine Encephalitis Virus-Like Particle
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ Pubmed: 37295404 DOI: doi:10.1016/j.cell.2023.05.019 ]
Cryo-EM structure of Antibody SKT05 in complex with Western Equine Encephalitis Virus-like Particle
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ Pubmed: 37295404 DOI: doi:10.1016/j.cell.2023.05.019 ]