Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7upw
Q-score: 0.464
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Three rbd-down state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (650 kDa, Complex)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7upx
Q-score: 0.513
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- Three rbd-down state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (local refinement of the rbd and fab variable domains) (6 MDa, Complex)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7upy
Q-score: 0.384
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- One rbd-up state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (650 kDa, Complex)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sp1-77 antibody fab light chain, sp1-77 antibody fab heavy chain (Complex from Mus musculus)
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Complex of sars-cov2 2p spike with sp1-77 antibody fab (48 kDa, Complex)
- Sp1-77 antibody fab light chain (Protein from Mus musculus)
- Sp1-77 antibody fab heavy chain (Protein from Mus musculus)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Vhh7-7-53 antibody light chain (Protein from Mus musculus)
- Vhh7-7-53 antibody fab light chain, vhh7-7-53 antibody fab heavy chain (Complex from Mus musculus)
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Complex of sars-cov2 2p spike with vhh7-7-53 antibody fab (48 kDa, Complex)
- Vhh7-7-53 antibody heavy chain (Protein from Mus musculus)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Vhh7-5-82 antibody fab light chain, vhh7-5-82 antibody fab heavy chain (Complex from Mus musculus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Complex of sars-cov2 2p spike with vhh7-5-82 antibody fab (48 kDa, Complex)
- Vhh7-5-82 antibody fab heavy chain (Protein from Mus musculus)
- Vhh7-5-82 antibody fab light chain (Protein from Mus musculus)