Cryo-EM structure of SARS-CoV-2 S-BQ.1 in complex with antibody O5C2
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8xbf
Q-score: 0.257
Chang YH, Hsu MF, Chen WN, Wu MH, Kong WL, Lu MJ, Huang CH, Chang FJ, Chang LY, Tsai HY, Tung CP, Yu JH, Kuo Y, Chou YC, Bai LY, Chang YC, Chen AY, Chen CC, Chen YH, Liao CC, Chang CS, Liang JJ, Lin YL, Angata T, Hsu SD, Lin KI
JCI Insight (2024) 9 [ Pubmed: 38775156 DOI: doi:10.1172/jci.insight.179726 ]
- Antibody o5c2, heavy chain (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody o5c2, light chain (Complex from Homo sapiens)
- O5c2, light chain (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 s-bq.1 and antibody o5c2 complex (Complex)
- Bq.1 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- O5c2, heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8tnl
Q-score: 0.454
Jia M, Zhao H, Morano NC, Lu H, Lui YM, Du H, Becker JE, Yuen KY, Ho DD, Kwong PD, Shapiro L, To KK, Wu X
Nat Commun (2024) 15 pp. 4505-4505 [ Pubmed: 38802413 DOI: doi:10.1038/s41467-024-48758-4 ]
- H7.hk1 neutralizing antibody heavy chain (12 kDa, Protein from Homo sapiens)
- H7 hemagglutinin from a/shanghai2/2013 h7n9 in complex with a human neutralizing antibody h7.hk1 (Complex from Homo sapiens)
- Hemagglutinin (63 kDa, Protein from Influenza A virus (A/Shanghai/02/2013(H7N9)))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- H7.hk1 neutralizing antibody heavy chain (12 kDa, Protein from Homo sapiens)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 8toa
Q-score: 0.342
Jia M, Zhao H, Morano NC, Lu H, Lui YM, Du H, Becker JE, Yuen KY, Ho DD, Kwong PD, Shapiro L, To KK, Wu X
Nat Commun (2024) 15 pp. 4505-4505 [ Pubmed: 38802413 DOI: doi:10.1038/s41467-024-48758-4 ]
- H7.hk2 neutralizing antibody light chain (12 kDa, Protein from Homo sapiens)
- H7.hk2 neutralizing antibody heavy chain (13 kDa, Protein from Homo sapiens)
- H7 hemagglutinin from a/shanghai2/2013 h7n9 in complex with a human neutralizing antibody h7.hk1 (Complex from Homo sapiens)
- Hemagglutinin (63 kDa, Protein from Influenza A virus (A/Shanghai/02/2013(H7N9)))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9axf
Q-score: 0.56
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ DOI: doi:10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
- Phosphate ion (94 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human casr in complex with chimeric gq (minigisq) protein (319 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,adenylate cyclase-stimulating g alpha protein (28 kDa, Protein from Homo sapiens)
- Extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Single-chain antibody fragment scfv16 (31 kDa, Protein from Mus musculus)
- Cyclomethyltryptophan (216 Da, Ligand)
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody nb-35 (17 kDa, Protein from Lama glama)
Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9ayf
Q-score: 0.529
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
Nature (2024) 629 pp. 481-488 [ DOI: doi:10.1038/s41586-024-07331-1 Pubmed: 38632411 ]
- Phosphate ion (94 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Human casr in complex with minigi1 protein in detergent (301 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (25 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Single-chain antibody fragment scfv16 (31 kDa, Protein from Mus musculus)
- Cyclomethyltryptophan (216 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform 1 of extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
Cryo-EM structure of Long-wave-sensitive opsin 1
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8iu2
Q-score: 0.482
To Be Published
- Retinal (284 Da, Ligand)
- Long-wave-sensitive opsin 1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Long-wave-sensitive opsin 1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv recombinant human monoclonal antibody (scfv16) (27 kDa, Protein from Homo sapiens)
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 8u1d
Q-score: 0.359
Saunders KO, Counts J, Thakur B, Stalls V, Edwards R, Manne K, Lu X, Mansouri K, Chen Y, Parks R, Barr M, Sutherland L, Bal J, Havill N, Chen H, Machiele E, Jamieson N, Hora B, Kopp M, Janowska K, Anasti K, Jiang C, Van Itallie E, Venkatayogi S, Eaton A, Henderson R, Barbosa C, Alam SM, Santra S, Weissman D, Moody MA, Cain DW, Tam YK, Lewis M, Williams WB, Wiehe K, Montefiori DC, Acharya P, Haynes BF
Cell (2024) 187 pp. 79-94.e24 [ DOI: doi:10.1016/j.cell.2023.12.002 Pubmed: 38181743 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh1285 light chain (25 kDa, Protein from Macaca mulatta)
- Dh1285 heavy chain, dh1285 light chain (Complex from Macaca mulatta)
- The complex of vaccine elicited cd4 binding site neutralizing antibody dh1285 fab with ch505m5chimer.6r.sosip.664v4.1 env (308 kDa, Complex)
- Envelope glycoprotein gp120 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (72 kDa, Protein from Human immunodeficiency virus 1)
- Dh1285 heavy chain (26 kDa, Protein from Macaca mulatta)
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8dtk
Q-score: 0.437
Malewana RD, Stalls V, May A, Lu X, Martinez DR, Schafer A, Li D, Barr M, Sutherland LL, Lee E, Parks R, Beck WE, Newman A, Bock KW, Minai M, Nagata BM, DeMarco CT, Denny TN, Oguin 3rd TH, Rountree W, Wang Y, Mansouri K, Edwards RJ, Sempowski GD, Eaton A, Muramatsu H, Henderson R, Tam Y, Barbosa C, Tang J, Cain DW, Santra S, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Montefiori DC, Pardi N, Weissman D, Baric RS, Acharya P, Haynes BF, Saunders KO
bioRxiv (2023) [ DOI: doi:10.1101/2023.12.18.572191 Pubmed: 38187726 ]
- Rbd directed antibody dh1047 in complex with sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Dh1047 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Dh1047 fab light chain (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Spike trimer in complex with RmAb 9H1 Fab in the class 1 conformation
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8heb
Q-score: 0.379
Chu X, Ding X, Yang Y, Lu Y, Li T, Gao Y, Zheng L, Xiao H, Yang T, Cheng H, Huang H, Liu Y, Lou Y, Wu C, Chen Y, Yang H, Ji X, Guo H
Biochem Biophys Res Commun (2023) 660 pp. 43-49 [ DOI: doi:10.1016/j.bbrc.2023.04.002 Pubmed: 37062240 ]
- Rabbit antibody 9h1 light chain (11 kDa, Protein from Oryctolagus cuniculus)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Rabbit antibody 9h1 heavy chain (12 kDa, Protein from Oryctolagus cuniculus)
- Sars-cov-2 wt spike glycoprotein complex with rmab 9h1 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 9h1 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Spike trimer in complex with RmAb 9H1 Fab in the class 2 conformation
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hec
Q-score: 0.358
Chu X, Ding X, Yang Y, Lu Y, Li T, Gao Y, Zheng L, Xiao H, Yang T, Cheng H, Huang H, Liu Y, Lou Y, Wu C, Chen Y, Yang H, Ji X, Guo H
Biochem Biophys Res Commun (2023) 660 pp. 43-49 [ DOI: doi:10.1016/j.bbrc.2023.04.002 Pubmed: 37062240 ]
- Rabbit antibody 9h1 light chain (11 kDa, Protein from Oryctolagus cuniculus)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Rabbit antibody 9h1 heavy chain (12 kDa, Protein from Oryctolagus cuniculus)
- Sars-cov-2 wt spike glycoprotein complex with rmab 9h1 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 9h1 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)