Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8dtk
Q-score: 0.437
Malewana RD, Stalls V, May A, Lu X, Martinez DR, Schafer A, Li D, Barr M, Sutherland LL, Lee E, Parks R, Beck WE, Newman A, Bock KW, Minai M, Nagata BM, DeMarco CT, Denny TN, Oguin 3rd TH, Rountree W, Wang Y, Mansouri K, Edwards RJ, Sempowski GD, Eaton A, Muramatsu H, Henderson R, Tam Y, Barbosa C, Tang J, Cain DW, Santra S, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Montefiori DC, Pardi N, Weissman D, Baric RS, Acharya P, Haynes BF, Saunders KO
bioRxiv (2023) [ DOI: doi:10.1101/2023.12.18.572191 Pubmed: 38187726 ]
- Rbd directed antibody dh1047 in complex with sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Dh1047 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Dh1047 fab light chain (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Dh1024 antibody fab (Complex from Macaca mulatta)
- Dh1024 antibody fab light chain (Protein from Macaca mulatta)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh1024 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 2)
- Dh1024 antibody fab light chain (Complex from Macaca mulatta)
- Dh1024 antibody fab heavy chain (Complex from Macaca mulatta)
- Dh1024 antibody fab heavy chain (Protein from Macaca mulatta)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Dh1025.1 antibody fab light chain (Complex from Macaca mulatta)
- Dh1025.1 antibody fab (Complex from Macaca mulatta)
- Dh1025.1 antibody fab heavy chain (Complex from Macaca mulatta)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 1)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh1025.1 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Dh1025.1 antibody fab heavy chain (Protein from Macaca mulatta)
- Dh1025.1 antibody fab light chain (Protein from Macaca mulatta)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh1027 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 1)
- Dh1027 antibody fab light chain (Complex from Macaca mulatta)
- Dh1027 antibody fab heavy chain (Protein from Macaca mulatta)
- Dh1027 antibody fab heavy chain (Complex from Macaca mulatta)
- Dh1027 antibody fab (Complex from Macaca mulatta)
- Dh1027 antibody fab light chain (Protein from Macaca mulatta)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Dh1028 antibody fab heavy chain (Protein from Macaca mulatta)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh1028 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Dh1028 antibody fab light chain (Protein from Macaca mulatta)
- Dh1028 antibody fab light chain (Complex from Macaca mulatta)
- Dh1028 antibody fab heavy chain (Complex from Macaca mulatta)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 1)
- Dh1028 antibody fab (Complex from Macaca mulatta)
Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Dh950 antibody fab heavy chain (Complex from Homo sapiens)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh950 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Dh950 antibody fab heavy chain (Protein from Homo sapiens)
- Dh950 antibody fab (Complex from Homo sapiens)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 1)
- Dh950 antibody fab light chain (Complex from Homo sapiens)
- Dh950 antibody fab light chain (Protein from Homo sapiens)
Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6um6
Q-score: 0.318
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ Pubmed: 31806786 DOI: doi:10.1126/science.aay7199 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of antibody dh270.6 with hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- Dh270.6 light chain (22 kDa, Protein from Homo sapiens)
- Dh270.6 heavy chain (25 kDa, Protein from Homo sapiens)
- Ch848 10.17dt gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 10.17dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)