SARS CoV2 spike in complex with NTD-directed antibody Fab DH1052
Pierre CN, Adams LE, Higgins JS, Anasti K, Goodman D, Mielke D, Stanfield-Oakley S, Powers JM, Li D, Rountree W, Wang Y, Edwards RJ, Alam SM, Ferrari G, Tomaras GD, Haynes BF, Baric RS, Saunders KO
PLoS Pathog (2024) 20 pp. e1011569-e1011569 [ Pubmed: 38900807 DOI: doi:10.1371/journal.ppat.1011569 ]
SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 7y71
Q-score: 0.415
Chia WN, Tan CW, Tan AWK, Young B, Starr TN, Lopez E, Fibriansah G, Barr J, Cheng S, Yeoh AY, Yap WC, Lim BL, Ng TS, Sia WR, Zhu F, Chen S, Zhang J, Kwek MSS, Greaney AJ, Chen M, Au GG, Paradkar PN, Peiris M, Chung AW, Bloom JD, Lye D, Lok S, Wang LF
Sci Adv (2023) 9 pp. eade3470-eade3470 [ DOI: doi:10.1126/sciadv.ade3470 Pubmed: 37494438 ]
- Fab e7 heavy chain (23 kDa, Protein from Homo sapiens)
- Fab e7 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (132 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein trimer complexed with fab fragment of anti-rbd antibody e7 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.03 Å
EM Method: Single-particle
Fitted PDBs: 7y72
Q-score: 0.395
Chia WN, Tan CW, Tan AWK, Young B, Starr TN, Lopez E, Fibriansah G, Barr J, Cheng S, Yeoh AY, Yap WC, Lim BL, Ng TS, Sia WR, Zhu F, Chen S, Zhang J, Kwek MSS, Greaney AJ, Chen M, Au GG, Paradkar PN, Peiris M, Chung AW, Bloom JD, Lye D, Lok S, Wang LF
Sci Adv (2023) 9 pp. eade3470-eade3470 [ DOI: doi:10.1126/sciadv.ade3470 Pubmed: 37494438 ]
- Spike glycoprotein (132 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein trimer complexed with fab fragment of anti-rbd antibody e7 (Complex from Homo sapiens)
- Fab e7 heavy chain (23 kDa, Protein from Homo sapiens)
- Fab e7 light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of the TRH-bound human TRHR-Gq complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7xw9
Q-score: 0.543
Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C
Cell Discov (2022) 8 pp. 116-116 [ Pubmed: 36280665 DOI: doi:10.1038/s41421-022-00477-0 ]
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Trh peptide (362 Da, Protein from synthetic construct)
- Cryo-em structure of the trh-bound trhr-gq complex (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- G protein (Complex from Homo sapiens)
- Trh peptide (Complex)
- Thyrotropin-releasing hormone receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (46 kDa, Protein from Homo sapiens)
- Antibody (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7wic
Q-score: 0.509
Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C
Cell Res (2022) 32 pp. 785-788 [ DOI: doi:10.1038/s41422-022-00669-z Pubmed: 35578016 ]
- Cryo-em structure of the ss-14-bound sstr2-gi1 complex (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Somatostatin receptor type 2 (41 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (Complex from Homo sapiens)
- Antibody (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7wig
Q-score: 0.527
Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C
Cell Res (2022) 32 pp. 785-788 [ DOI: doi:10.1038/s41422-022-00669-z Pubmed: 35578016 ]
- ~{n}-[(2~{r})-1-[[(1~{r},3~{s})-3-(aminomethyl)cyclohexyl]methylamino]-3-(1~{h}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide (539 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Somatostatin receptor type 2 (41 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (Complex from Homo sapiens)
- Cryo-em structure of the l-054,264-bound sstr2-gi1 complex (180 kDa, Complex)
- Antibody (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 46C12 antibody Fab fragment
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7pnm
Q-score: 0.315
Wang C, Hesketh EL, Shamorkina TM, Li W, Franken PJ, Drabek D, van Haperen R, Townend S, van Kuppeveld FJM, Grosveld F, Ranson NA, Snijder J, de Groot RJ, Hurdiss DL, Bosch BJ
Nat Commun (2022) 13 pp. 2921-2921 [ DOI: doi:10.1038/s41467-022-30658-0 Pubmed: 35614127 ]
- Spike glycoprotein (146 kDa, Protein from Human coronavirus OC43)
- 46c12 antibody heavy chain (13 kDa, Protein from Homo sapiens)
- 46c12 antibody light chain (12 kDa, Protein from Homo sapiens)
- Human coronavirus oc43 spike glycoprotein ectodomain in complex with the 46c12 antibody fab fragment (583 kDa, Complex from Human coronavirus OC43)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 43E6 antibody Fab fragment
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7pnq
Q-score: 0.166
Wang C, Hesketh EL, Shamorkina TM, Li W, Franken PJ, Drabek D, van Haperen R, Townend S, van Kuppeveld FJM, Grosveld F, Ranson NA, Snijder J, de Groot RJ, Hurdiss DL, Bosch BJ
Nat Commun (2022) 13 pp. 2921-2921 [ DOI: doi:10.1038/s41467-022-30658-0 Pubmed: 35614127 ]
- 43e6 antibody light chain (11 kDa, Protein from Homo sapiens)
- 43e6 antibody heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (146 kDa, Protein from Human coronavirus OC43)
- Human coronavirus oc43 spike glycoprotein ectodomain in complex with the 43e6 antibody fab fragment (583 kDa, Complex from Human coronavirus OC43)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 47C9 antibody Fab fragment
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7po5
Q-score: 0.306
Wang C, Hesketh EL, Shamorkina TM, Li W, Franken PJ, Drabek D, van Haperen R, Townend S, van Kuppeveld FJM, Grosveld F, Ranson NA, Snijder J, de Groot RJ, Hurdiss DL, Bosch BJ
Nat Commun (2022) 13 pp. 2921-2921 [ DOI: doi:10.1038/s41467-022-30658-0 Pubmed: 35614127 ]
- Spike glycoprotein (146 kDa, Protein from Human coronavirus OC43)
- 47c9 antibody heavy chain (13 kDa, Protein from Homo sapiens)
- 47c9 antibody light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human coronavirus oc43 spike glycoprotein ectodomain in complex with the 47c9 antibody fab fragment (583 kDa, Complex from Human coronavirus OC43)
Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 37F1 antibody Fab fragment
Wang C, Hesketh EL, Shamorkina TM, Li W, Franken PJ, Drabek D, van Haperen R, Townend S, van Kuppeveld FJM, Grosveld F, Ranson NA, Snijder J, de Groot RJ, Hurdiss DL, Bosch BJ
Nat Commun (2022) 13 pp. 2921-2921 [ DOI: doi:10.1038/s41467-022-30658-0 Pubmed: 35614127 ]
- Human coronavirus oc43 spike glycoprotein (Protein from Human coronavirus OC43)
- Human coronavirus oc43 spike glycoprotein ectodomain (Complex from Homo sapiens)
- 37f1 antibody light chain (Protein from Homo sapiens)
- Human coronavirus oc43 spike glycoprotein ectodomain in complex with the 37f1 antibody fab fragment (583 kDa, Complex from Human coronavirus OC43)
- 37f1 antibody fab fragment (Complex)
- 37f1 antibody heavy chain (Protein from Homo sapiens)