Cryo-EM structure of human dimeric APJR complex with antagonistic antibody
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8xqj
Q-score: 0.444
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Cholesterol (386 Da, Ligand)
- Jn241 (17 kDa, Protein from Homo sapiens)
- Apjr complex with antibody (Complex from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
Cryo-EM structure of APJR complex with agonistic antibody
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8z74
Q-score: 0.394
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Apjr complex with antibody (Complex from Homo sapiens)
- Agonistic antibody (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of APJR-Gi complex with agonistic antibody
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8z7j
Q-score: 0.388
Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F
Nat Commun (2025) 16 pp. 310-310 [ DOI: doi:10.1038/s41467-024-55555-6 Pubmed: 39747115 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,apelin receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Agonistic antibody (13 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Apjr complexed with gi (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8xtw
Q-score: 0.509
To Be Published
- Green fluorescent protein,vesicular acetylcholine transporter,antibody (91 kDa, Protein from Homo sapiens)
- Transporter (Complex from Homo sapiens)
- Acetylcholine (146 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8xtx
Q-score: 0.485
To Be Published
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8xty
Q-score: 0.48
To Be Published
- Vesamicol (259 Da, Ligand)
- Green fluorescent protein,vesicular acetylcholine transporter,green fluorescent protein,vesicular acetylcholine transporter,green fluorescent protein,vesicular acetylcholine transporter,green fluorescent protein,vesicular acetylcholine transporter,antibody (89 kDa, Protein from Homo sapiens)
- Transporter (Complex from Homo sapiens)
CryoEM structure of sNS1 complexed with Fab 4F10
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jqm
Q-score: 0.624
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- The complex of zikv ns1 with antibody 4f10 (Complex)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- 4f10 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Antibody 4f10 (Complex from Homo sapiens)
- Zikv ns1 (Complex from Zika virus)
- 4f10 fab light chain (11 kDa, Protein from Homo sapiens)
CryoEM structure of sNS1 complexed with Fab 3G2
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8jkf
Q-score: 0.581
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- The light chain of antibody 3g2 (11 kDa, Protein from Homo sapiens)
- Antibody 3g2 (Complex from Homo sapiens)
- The complex of zikv ns1 with antibody 3g2 (Complex)
- The heavy chain of antibody 3g2 (12 kDa, Protein from Homo sapiens)
- Zikv ns1 (Complex from Zika virus)
- Ns1 (40 kDa, Protein from Zika virus)
CryoEM structure of sNS1 complexed with Fab 2E11
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jqn
Q-score: 0.605
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Antibody 2e11 (Complex from Homo sapiens)
- Non-structural protein 1 (40 kDa, Protein from Zika virus)
- 2e11 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Zikv ns1 (Complex from Zika virus)
- 2e11 fab light chain (11 kDa, Protein from Homo sapiens)
- The complex of zikv ns1 with antibody 2e11 (Complex)
CryoEM structure of sNS1 complexed with Fab 4B8
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8jkh
Q-score: 0.569
Pan Q, Xing X, Yu J, Chen Q, Jiao H, Zhang W, Wen Y, Gao M, Zhao W, Yu L, Hu H
Hlife (2024) 2 pp. 527-541 [ DOI: doi:10.1016/j.hlife.2024.05.003 ]
- Antibody 4b8 (Complex from Homo sapiens)
- The light chain of antibody 4b8 (11 kDa, Protein from Homo sapiens)
- Zikv ns1 (Complex from Zika virus)
- The heavy chain of antibody 4b8 (12 kDa, Protein from Homo sapiens)
- Ns1 (40 kDa, Protein from Zika virus)
- The complex of zikv ns1 with antibody 4b8 (Complex)