Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA, Budylowski P, Guvenc F, Newton JC, Sicard T, Semesi A, Muthuraman K, Nouanesengsy A, Aschner CB, Prieto K, Bueler SA, Youssef S, Liao-Chan S, Glanville J, Christie-Holmes N, Mubareka S, Gray-Owen SD, Rubinstein JL, Treanor B, Julien JP
Nat Commun (2021) 12 pp. 3661-3661 [ DOI: doi:10.1038/s41467-021-23825-2 Pubmed: 34135340 ]
- Fab 46 heavy chain (Protein from Homo sapiens)
- Fab 46 light chain (Protein from Homo sapiens)
- Receptor binding domain of sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab fragment of neutralizing antibody 46 (Complex from Homo sapiens)
- Sars-cov-2 receptor binding domain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 receptor binding domain in complex with the fab fragment of neutralizing antibody 46 (Complex)
Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA, Budylowski P, Guvenc F, Newton JC, Sicard T, Semesi A, Muthuraman K, Nouanesengsy A, Aschner CB, Prieto K, Bueler SA, Youssef S, Liao-Chan S, Glanville J, Christie-Holmes N, Mubareka S, Gray-Owen SD, Rubinstein JL, Treanor B, Julien JP
Nat Commun (2021) 12 pp. 3661-3661 [ DOI: doi:10.1038/s41467-021-23825-2 Pubmed: 34135340 ]
- Fab 80 light chain (Protein from Homo sapiens)
- Fab fragment of neutralizing antibody 80 (Complex from Homo sapiens)
- Sars-cov-2 spike in complex with the fab fragment of neutralizing antibody 80 (Complex)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab 80 heavy chain (Protein from Homo sapiens)
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA, Budylowski P, Guvenc F, Newton JC, Sicard T, Semesi A, Muthuraman K, Nouanesengsy A, Aschner CB, Prieto K, Bueler SA, Youssef S, Liao-Chan S, Glanville J, Christie-Holmes N, Mubareka S, Gray-Owen SD, Rubinstein JL, Treanor B, Julien JP
Nat Commun (2021) 12 pp. 3661-3661 [ DOI: doi:10.1038/s41467-021-23825-2 Pubmed: 34135340 ]
- Fab fragment of neutralizing antibody 298 (Complex from Homo sapiens)
- Sars-cov-2 spike in complex with the fab fragment of neutralizing antibody 298 (Complex)
- Fab 298 heavy chain (Protein from Homo sapiens)
- Fab 298 light chain (Protein from Homo sapiens)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA, Budylowski P, Guvenc F, Newton JC, Sicard T, Semesi A, Muthuraman K, Nouanesengsy A, Aschner CB, Prieto K, Bueler SA, Youssef S, Liao-Chan S, Glanville J, Christie-Holmes N, Mubareka S, Gray-Owen SD, Rubinstein JL, Treanor B, Julien JP
Nat Commun (2021) 12 pp. 3661-3661 [ DOI: doi:10.1038/s41467-021-23825-2 Pubmed: 34135340 ]
- Fab 324 light chain (Protein from Homo sapiens)
- Sars-cov-2 spike in complex with the fab fragment of neutralizing antibody 324 (Complex)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab 324 heavy chain (Protein from Homo sapiens)
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab fragment of neutralizing antibody 324 (Complex from Homo sapiens)
BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5v8l
Q-score: 0.346
Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR, Ward AB
Immunity (2017) 46 pp. 690-702 [ DOI: doi:10.1016/j.immuni.2017.03.017 Pubmed: 28423342 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip.664 trimer in complex with pgt145 and 3bnc117 fabs (560 kDa, Complex from Human immunodeficiency virus 1)
- 3bnc117 antibody, light chain (23 kDa, Protein from Homo sapiens)
- Pgt145 antibody, heavy chain (28 kDa, Protein from Homo sapiens)
- Pgt145 antibody, light chain (23 kDa, Protein from Homo sapiens)
- 3bnc117 antibody, heavy chain (24 kDa, Protein from Homo sapiens)
- Gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibody 3BNC117
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5v8m
Q-score: 0.347
Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR, Ward AB
Immunity (2017) 46 pp. 690-702 [ DOI: doi:10.1016/j.immuni.2017.03.017 Pubmed: 28423342 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip.664 soluble env trimer in complex with 3bnc117 fab (510 kDa, Complex from Homo sapiens)
- Antibody 3bnc117, light chain (23 kDa, Protein from Homo sapiens)
- Gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Antibody 3bnc117, heavy chain (24 kDa, Protein from Homo sapiens)
- Gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Negative stain EM reconstruction of HIV-1 Env AMC008 SOSIP.v4 in complex with Fabs 35O22 and PGV04
de Taeye SW, Ozorowski G, Torrents de la Pena A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, DeStefano J, Koff WC, Schuitemaker H, Eggink D, Berkhout B, Dean H, LaBranche C, Crotty S, Crispin M, Montefiori DC, Klasse PJ, Lee KK, Moore JP, Wilson IA, Ward AB, Sanders RW
Cell (2015) 163 pp. 1702-1715 [ Pubmed: 26687358 DOI: doi:10.1016/j.cell.2015.11.056 ]
- Anti-hiv-1 antibody 35o22 fab (50 kDa, Protein from Homo sapiens)
- Hiv-1 amc008 env sosip.v4 (420 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 env amc008 sosip.v4 in complex with broadly neutralizing antibody fabs 35o22 and pgv04 (720 kDa, Sample)
- Anti-hiv-1 antibody pgv04 fab (50 kDa, Protein from Homo sapiens)
ZM197 SOSIP.664 trimer in complex with VRC01 Fab
Julien JP, Lee JH, Ozorowski G, Hua Y, Torrents de la Pena A, de Taeye SW, Nieusma T, Cupo A, Yasmeen A, Golabek M, Pugach P, Klasse PJ, Moore JP, Sanders RW, Ward AB, Wilson IA
PNAS (2015) 112 pp. 11947-11952 [ DOI: doi:10.1073/pnas.1507793112 Pubmed: 26372963 ]
- Vrc01 antibody (500 kDa, Protein from Homo sapiens)
- Hiv-1 env (420 kDa, Protein from Human immunodeficiency virus 1)
- Fab of vrc01 antibody bound to a clade c zm176 sosip.664 trimer (570 kDa, Sample)
PGT124 in complex with BG505 SOSIP.664 Env trimer
Garces F, Sok D, Kong L, McBride R, Kim HJ, Saye-Francisco KF, Julien JP, Hua Y, Cupo A, Moore JP, Paulson JC, Ward AB, Burton DR, Wilson IA
Cell (2014) 159 pp. 69-79 [ DOI: doi:10.1016/j.cell.2014.09.009 Pubmed: 25259921 ]
- Fab fragment of pgt124 monoclonal antibody isolated from human patient in protocol g cohort. sosip.664 soluble env trimer from hiv-1 virus infecting infant (bg505). (750 kDa, Sample)
- Bg505 sosip.664 gp140 (600 kDa, Protein from Homo sapiens)
- Fragment antigen binding (50 kDa, Protein from Homo sapiens)
3BNC117 Fab in complex with BG505 SOSIP.664 Trimer
Derking R, Ozorowski G, Sliepen K, Yasmeen A, Cupo A, Torres JL, Julien J-P, Lee JH, van Montfort T, de Taeye SW, Connors M, Burton DR, Wilson IA, Klasse PJ, Ward AB, Moore JP, Sanders RW
PLoS Pathog (2015) 11 pp. e1004767-e1004767 [ DOI: doi:10.1371/journal.ppat.1004767 Pubmed: 25807248 ]