cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and VacW-209
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N
Protein Cell (2024) 15 pp. 121-134 [ Pubmed: 37470320 DOI: doi:10.1093/procel/pwad040 ]
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 7wp0
Q-score: 0.48
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Vacw-209 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 delta s6p trimer in complex with neutralizing antibody vacw-209 (Complex from Homo sapiens)
- Sars-cov-2 delta (Complex)
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ig c335_light_iglv1-40_iglj3 (11 kDa, Protein from Homo sapiens)
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 7wp2
Q-score: 0.498
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vacw-209 light chain (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 c.1.2 s6p trimer in complex with neutralizing antibody vacw-209 (Complex from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7won
Q-score: 0.464
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Vacw-209 light chain (11 kDa, Protein from Homo sapiens)
- Neutralizing antibody vacw-209 (Complex)
- Sars-cov-2 s2p (Complex from Homo sapiens)
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s2p trimer in complex with neutralizing antibody vacw-209 (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 7wp1
Q-score: 0.463
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Sars-cov-2 mu s6p trimer in complex with neutralizing antibody vacw-209 (Complex from Homo sapiens)
- Antibody vacw-209 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vacw-209 light chain (11 kDa, Protein from Homo sapiens)
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
- Sars-cov-2 mu (Complex)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7wp5
Q-score: 0.445
Ju B, Zheng Q, Guo H, Fan Q, Li T, Song S, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S, Xia N, Zhang Z
Cell Res (2022) 32 pp. 491-494 [ DOI: doi:10.1038/s41422-022-00638-6 Pubmed: 35260792 ]
- Sars-cov-2 omicron s6p trimer in complex with neutralizing antibody vacw-209 (Complex from Homo sapiens)
- Vacw-209 heavy chain (14 kDa, Protein from Homo sapiens)
- Spikeprotein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vacw-209 light chain (11 kDa, Protein from Homo sapiens)
