Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7upw
Q-score: 0.464
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Three rbd-down state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (650 kDa, Complex)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7upx
Q-score: 0.513
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- Three rbd-down state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (local refinement of the rbd and fab variable domains) (6 MDa, Complex)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7upy
Q-score: 0.384
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- One rbd-up state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (650 kDa, Complex)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sp1-77 antibody fab light chain, sp1-77 antibody fab heavy chain (Complex from Mus musculus)
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Complex of sars-cov2 2p spike with sp1-77 antibody fab (48 kDa, Complex)
- Sp1-77 antibody fab light chain (Protein from Mus musculus)
- Sp1-77 antibody fab heavy chain (Protein from Mus musculus)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Vhh7-7-53 antibody light chain (Protein from Mus musculus)
- Vhh7-7-53 antibody fab light chain, vhh7-7-53 antibody fab heavy chain (Complex from Mus musculus)
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Complex of sars-cov2 2p spike with vhh7-7-53 antibody fab (48 kDa, Complex)
- Vhh7-7-53 antibody heavy chain (Protein from Mus musculus)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Vhh7-5-82 antibody fab light chain, vhh7-5-82 antibody fab heavy chain (Complex from Mus musculus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Complex of sars-cov2 2p spike with vhh7-5-82 antibody fab (48 kDa, Complex)
- Vhh7-5-82 antibody fab heavy chain (Protein from Mus musculus)
- Vhh7-5-82 antibody fab light chain (Protein from Mus musculus)
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 7the
Q-score: 0.414
Gobeil SM, Henderson R, Stalls V, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Manne K, Li D, Parks R, Barr M, Deyton M, Martin M, Mansouri K, Edwards RJ, Eaton A, Montefiori DC, Sempowski GD, Saunders KO, Wiehe K, Williams W, Korber B, Haynes BF, Acharya P
Mol Cell (2022) 82 pp. 2050-2068.e6 [ DOI: doi:10.1016/j.molcel.2022.03.028 Pubmed: 35447081 ]
- Rbd directed antibody dh1042 in complex with sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Dh1042 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Dh1042 fab light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
CryoEM map of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1042
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7tht
Q-score: 0.407
Gobeil SM, Henderson R, Stalls V, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Manne K, Li D, Parks R, Barr M, Deyton M, Martin M, Mansouri K, Edwards RJ, Eaton A, Montefiori DC, Sempowski GD, Saunders KO, Wiehe K, Williams W, Korber B, Haynes BF, Acharya P
Mol Cell (2022) 82 pp. 2050-2068.e6 [ DOI: doi:10.1016/j.molcel.2022.03.028 Pubmed: 35447081 ]
- Dh1042 heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh1042 light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with rbd antibody dh1042 (Complex)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody dh1042 (Complex from Homo sapiens)
Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 7sg4
Q-score: 0.355
Martinez DR, Schafer A, Gobeil S, Li D, De la Cruz G, Parks R, Lu X, Barr M, Stalls V, Janowska K, Beaudoin E, Manne K, Mansouri K, Edwards RJ, Cronin K, Yount B, Anasti K, Montgomery SA, Tang J, Golding H, Shen S, Zhou T, Kwong PD, Graham BS, Mascola JR, Montefiori DC, Alam SM, Sempowski G, Sempowski GD, Khurana S, Wiehe K, Saunders KO, Acharya P, Haynes BF, Baric RS
Sci Transl Med (2022) 14 pp. eabj7125-eabj7125 [ DOI: doi:10.1126/scitranslmed.abj7125 Pubmed: 34726473 ]
- Dh1047 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Dh1047 light chain (24 kDa, Protein from Homo sapiens)
- Sars-cov s protein in complex with receptor binding domain antibody dh1047 (Complex from Severe acute respiratory syndrome-related coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM map of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1041
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7laa
Q-score: 0.416
Li D, Edwards RJ, Manne K, Martinez DR, Schafer A, Alam SM, Wiehe K, Lu X, Parks R, Sutherland LL, Oguin 3rd TH, McDanal C, Perez LG, Mansouri K, Gobeil SMC, Janowska K, Stalls V, Kopp M, Cai F, Lee E, Foulger A, Hernandez GE, Sanzone A, Tilahun K, Jiang C, Tse LV, Bock KW, Minai M, Nagata BM, Cronin K, Gee-Lai V, Deyton M, Barr M, Von Holle T, Macintyre AN, Stover E, Feldman J, Hauser BM, Caradonna TM, Scobey TD, Rountree W, Wang Y, Moody MA, Cain DW, DeMarco CT, Denny TN, Woods CW, Petzold EW, Schmidt AG, Teng IT, Zhou T, Kwong PD, Mascola JR, Graham BS, Moore IN, Seder R, Andersen H, Lewis MG, Montefiori DC, Sempowski GD, Baric RS, Acharya P, Haynes BF, Saunders KO
Cell (2021) 184 pp. 4203- [ DOI: doi:10.1016/j.cell.2021.06.021 Pubmed: 34242577 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh1041 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody dh1041 (Complex from Homo sapiens)
- Dh1041 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with rbd antibody dh1041 (Complex)