Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn7
Q-score: 0.548
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- 4-(1h-imidazol-4-ylmethyl)pyridine (159 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(o) subunit alpha,guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Immethridine-h3r-minigo-scfv16 complex (Complex from Homo sapiens)
Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn8
Q-score: 0.544
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Engineered guanine nucleotide-binding protein g(o) subunit alpha,guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Proxyfan-h3r-minigo-scfv16 complex (Complex from Homo sapiens)
- 5-(3-phenylmethoxypropyl)-1h-imidazole (216 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8yn2
Q-score: 0.578
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h1 receptor (80 kDa, Protein from Homo sapiens)
- Histamine-h1r-minigq-scfv16 complex (Complex from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (28 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8yn4
Q-score: 0.515
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Histamine-h2r-minigq-scfv16 complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h2 receptor (62 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (28 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H3 receptor in complex with histamine and Gi
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yn5
Q-score: 0.589
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Histamine-h3r-gi-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Histamine (111 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H3 receptor in complex with imetit and Gi
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn6
Q-score: 0.546
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Imetit-h3r-gi-scfv16 complex (Complex from Homo sapiens)
- 2-(1~{h}-imidazol-5-yl)ethyl carbamimidothioate (170 Da, Ligand)
Cryo-EM structure of histamine H4 receptor in complex with histamine and Gi
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8yn9
Q-score: 0.628
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Water (18 Da, Ligand)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (71 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine-h4r-gi-scfv16 complex (Complex from Homo sapiens)
Cryo-EM structure of histamine H4 receptor in complex with immepip and Gi
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8yna
Q-score: 0.586
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Immepip-h4r-gi-scfv16 complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- 4-(1h-imidazol-5-ylmethyl)piperidine (165 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8xjk
Q-score: 0.588
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Cloprosetnol-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Cloprostenol (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8xjl
Q-score: 0.559
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Pgf2-alpha-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- (z)-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(e,3s)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid (354 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)