Cryo-EM structure of Antibody SKW11 in complex with Western Equine Encephalitis Virus-Like Particle
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ Pubmed: 37295404 DOI: doi:10.1016/j.cell.2023.05.019 ]
Cryo-EM I1 reconstruction of antibody SKV09 in complex with VEEV alphavirus VLP
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ Pubmed: 37295404 DOI: doi:10.1016/j.cell.2023.05.019 ]
Cryo-EM local refinement of antibody SKV09 in complex with VEEV alphavirus spike glycoprotein
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 8deq
Q-score: 0.19
Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schon A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Cell (2023) 186 pp. 2672-2689.e25 [ Pubmed: 37295404 DOI: doi:10.1016/j.cell.2023.05.019 ]
- Cryo-em local refinement of antibody skv09 in complex with veev alphavirus spike glycoprotein (Complex from Venezuelan equine encephalitis virus)
- Skv09 fab heavy chain (13 kDa, Protein from Macaca)
- Spike glycoprotein e1 (43 kDa, Protein from Venezuelan equine encephalitis virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Skv09 fab light chain (11 kDa, Protein from Macaca)
Antibody 10-28 in complex with prefusion SARS-CoV-2 B.1.351 Spike glycoprotein
Liu L, Iketani S, Guo Y, Reddem ER, Casner RG, Nair MS, Yu J, Chan JF, Wang M, Cerutti G, Li Z, Morano NC, Castagna CD, Corredor L, Chu H, Yuan S, Poon VK, Chan CC, Chen Z, Luo Y, Cunningham M, Chavez A, Yin MT, Perlin DS, Tsuji M, Yuen KY, Kwong PD, Sheng Z, Huang Y, Shapiro L, Ho DD
Sci Transl Med (2022) 14 pp. eabn6859-eabn6859 [ DOI: doi:10.1126/scitranslmed.abn6859 Pubmed: 35438546 ]
- Antibody 10-28 light (Protein from Homo sapiens)
- Antibody 10-28 heavy (Protein from Homo sapiens)
- Antibody 10-28 in complex with prefusion sars-cov-2 b.1.351 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
Antibody 11-11 in complex with prefusion SARS-CoV-2 B.1.351 Spike glycoprotein
Liu L, Iketani S, Guo Y, Reddem ER, Casner RG, Nair MS, Yu J, Chan JF, Wang M, Cerutti G, Li Z, Morano NC, Castagna CD, Corredor L, Chu H, Yuan S, Poon VK, Chan CC, Chen Z, Luo Y, Cunningham M, Chavez A, Yin MT, Perlin DS, Tsuji M, Yuen KY, Kwong PD, Sheng Z, Huang Y, Shapiro L, Ho DD
Sci Transl Med (2022) 14 pp. eabn6859-eabn6859 [ DOI: doi:10.1126/scitranslmed.abn6859 Pubmed: 35438546 ]
- Antibody 11-11 light chain (Protein from Homo sapiens)
- Antibody 11-11 heavy chain (Protein from Homo sapiens)
- Spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody 11-11 in complex with prefusion sars-cov-2 b.1.351 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 (Protein from Human immunodeficiency virus 1)
- Dh898.1 fab light chain (Protein from Macaca mulatta)
- Antibody dh898.1 fab-dimer bound to glycans 332, 392, and 396 of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (94 kDa, Complex)
- Dh898.1 fab heavy chain (Protein from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Antibody dh898.1 fragment antigen binding (fab) dimer (Complex from Macaca mulatta)
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Dh898.1 fab light chain (Protein from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (210 kDa, Complex from Human immunodeficiency virus 1)
- Antibody dh898.1 fragment antigen binding (fab) dimer (94 kDa, Complex from Macaca mulatta)
- Antibody dh898.1 fab-dimer bound to glycans 332, 392, and 396 of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (304 kDa, Complex)
- Dh898.1 fab heavy chain (Protein from Macaca mulatta)
Resolution: 6.8 Å
EM Method: Single-particle
Fitted PDBs: 5u1f
Q-score: 0.18
Liu Q, Acharya P, Dolan MA, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D, Miao H, Bylund T, Chuang GY, Druz A, Zhou T, Rice WJ, Wigge C, Carragher B, Potter CS, Kwong PD, Lusso P
Nat Struct Mol Biol (2017) 24 pp. 370-378 [ DOI: doi:10.1038/nsmb.3382 Pubmed: 28218750 ]
- Antibody pgt145 (Complex from Homo sapiens)
- Hiv-1 env trimer (Complex from Human immunodeficiency virus 1)
- Hiv-1 env trimer in complex with antibody pgt145 and cd4 (Complex from Human immunodeficiency virus 1)
- Cd4 (Complex from Homo sapiens)
- Hiv-1 trimer (Complex from Human immunodeficiency virus 1)