Cryo-EM structure of myosin-1c bound to F-actin in the ADP-A state
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 9cfu
Q-score: 0.518
Chavali SS, Sindelar CV, Ostap ME
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Unconventional myosin-ic (92 kDa, Protein from Mus musculus)
- Complex of myosin-1c with f-actin (220 kDa, Complex from Rattus norvegicus)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Actin, alpha skeletal muscle (41 kDa, Protein from Oryctolagus cuniculus)
Cryo-EM structure of delta-NTR myosin-1c bound to F-actin
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 9cfv
Q-score: 0.535
Chavali SS, Sindelar CV, Ostap ME
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Unconventional myosin-ic (92 kDa, Protein from Mus musculus)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Complex of myosin-1c with f-actin (Complex from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Actin, alpha skeletal muscle (41 kDa, Protein from Oryctolagus cuniculus)
Cryo-EM structure of myosin-1c bound to F-actin in the ADP-B state
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 9cfw
Q-score: 0.438
Chavali SS, Sindelar CV, Ostap ME
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Unconventional myosin-ic (92 kDa, Protein from Mus musculus)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Complex of myosin-1c with f-actin (Complex from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Actin, alpha skeletal muscle (41 kDa, Protein from Oryctolagus cuniculus)
Cryo-EM structure of myosin-1c bound to F-actin in the Rigor state
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 9cfx
Q-score: 0.518
Chavali SS, Sindelar CV, Ostap ME
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Unconventional myosin-ic (92 kDa, Protein from Mus musculus)
- F-actin in complex with myosin-1c (Complex from Mus musculus)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Actin, alpha skeletal muscle (41 kDa, Protein from Oryctolagus cuniculus)
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Human KCNQ2-CaM in complex with QO-83
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8xo1
Q-score: 0.233
To Be Published
- ~{n}-[2-azanyl-3-fluoranyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]-3-cyclopentyl-propanamide (423 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (95 kDa, Protein from Homo sapiens)
- Human kcnq2-cam in complex with qo-83 (Complex from Homo sapiens)
Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 9cui
Q-score: 0.468
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Ancestral htrpv6 tetramer in complex with calmodulin (Complex from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Structure of human full-length derived TRPV6 channel in Calmodulin-bound state
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 9cuk
Q-score: 0.482
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Derived htrpv6 tetramer in complex with calmodulin (370 kDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Structure of chimeric RyR complex with flubendiamide
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8xji
Q-score: 0.34
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Flubendiamide (682 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chimeric ryr ca2+/atp/caffeine/cam1234/flu (2 MDa, Complex from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Structure of chimeric RyR Complex with tetraniliprole
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8xkh
Q-score: 0.326
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ DOI: doi:10.1038/s41467-024-53490-0 Pubmed: 39428398 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Chimeric ryr ca2+/atp/caffeine/cam1234/tet (2 MDa, Complex from Oryctolagus cuniculus)
- Tetraniliprole (544 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)