Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8odz
Q-score: 0.329
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ Pubmed: 38287195 DOI: doi:10.1038/s41594-023-01190-6 ]
- Interleukin-12 receptor subunit beta-2,calmodulin-1 (85 kDa, Protein from Mus musculus)
- Interleukin-12 subunit beta (35 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (63 kDa, Protein from Mus musculus)
- Interleukin-12 subunit alpha (25 kDa, Protein from Mus musculus)
- Murine il-12 in complex with mil-12rbeta1-dapk1 and mil-12rbeta2-calmodulin. (216 kDa, Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8oe0
Q-score: 0.208
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ Pubmed: 38287195 DOI: doi:10.1038/s41594-023-01190-6 ]
- Interleukin-12 receptor subunit beta-2,calmodulin-1 (85 kDa, Protein from Mus musculus)
- Interleukin-12 subunit beta (35 kDa, Protein from Mus musculus)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (63 kDa, Protein from Mus musculus)
- Interleukin-12 subunit alpha (25 kDa, Protein from Mus musculus)
- Murine il-12 in complex with mil-12rbeta1-dapk1 and mil-12rbeta2-calmodulin. (216 kDa, Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8oe4
Q-score: 0.294
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ Pubmed: 38287195 DOI: doi:10.1038/s41594-023-01190-6 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-23 subunit alpha (20 kDa, Protein from Homo sapiens)
- Interleukin-12 subunit beta (34 kDa, Protein from Homo sapiens)
- Interleukin-23 receptor,calmodulin-1 (54 kDa, Protein from Homo sapiens)
- Human il-23 in complex with hil-12rbeta1-dapk1 and hil-23r-calmodulin. (168 kDa, Complex from Mus musculus)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (60 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8pb1
Q-score: 0.424
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ Pubmed: 38287195 DOI: doi:10.1038/s41594-023-01190-6 ]
- Interleukin-12 receptor subunit beta-2,calmodulin-1 (85 kDa, Protein from Mus musculus)
- Interleukin-12 subunit beta (35 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (63 kDa, Protein from Mus musculus)
- Interleukin-12 subunit alpha (25 kDa, Protein from Mus musculus)
- Murine il-12 in complex with mil-12rbeta1-dapk1 and mil-12rbeta2-calmodulin. (216 kDa, Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)