human KCNQ2-CaM-Ebio1 complex in the presence of PIP2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ijk
Q-score: 0.383
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- Human kcnq2-cam-ebio1 complex in the presence of pip2 (Complex from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (291 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x43
Q-score: 0.328
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- Human kcnq2-cam-ebio1-s1 complex in the presence of pip2 (Cellular component from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (306 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Human KCNQ2-CaM in complex with CBD and PIP2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j01
Q-score: 0.421
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- Human kcnq2-cam in complex with cbd and pip2 (Complex from Homo sapiens)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Cannabidiol (314 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8j02
Q-score: 0.348
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- Human kcnq2(f104a)-cam-pip2-cbd complex in state ii (Complex from Homo sapiens)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Cannabidiol (314 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
human KCNQ2-CaM in complex with PIP2 and HN37
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w4u
Q-score: 0.354
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- Methyl n-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate (340 Da, Ligand)
- Human kcnq2-cam in complex with pip2 and hn37 (Cellular component from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state I
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j03
Q-score: 0.358
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- Human kcnq2(f104a)-cam-pip2-cbd complex in state i (Complex from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Cannabidiol (314 Da, Ligand)
Human KCNQ2-CaM-HN37 complex in the presence of PIP2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j04
Q-score: 0.329
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Methyl n-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate (340 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Human kcnq2-cam-hn37 complex in the presence of pip2 (Complex from Homo sapiens)
Human KCNQ2-CaM complex in the presence of PIP2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j05
Q-score: 0.343
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Human kcnq2-cam complex in the presence of pip2 (Complex from Homo sapiens)
Human KCNQ2-CaM in complex with CBD
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8j00
Q-score: 0.387
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ Pubmed: 37857637 DOI: doi:10.1038/s41467-023-42416-x ]
- Cannabidiol (314 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Human kcnq2-cam in complex with cbd (Complex from Homo sapiens)
Structure of RyR1 (Ca2+/Caffeine/ATP/CaM1234/CHL)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6m2w
Q-score: 0.309
Ma R, Haji-Ghassemi O, Ma D, Jiang H, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z
Nat Chem Biol (2020) 16 pp. 1246-1254 [ DOI: doi:10.1038/s41589-020-0627-5 Pubmed: 32807966 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1 (539 kDa, Protein from Oryctolagus cuniculus)
- Ryr1 ca2 /atp/caffeine/cam1234/chl (2 MDa, Complex)
- Zinc ion (65 Da, Ligand)
- Fkbp12.6 and cam1234 (Complex from Homo sapiens)
- Caffeine (194 Da, Ligand)
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryr1 (Complex from Oryctolagus cuniculus)