Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Structure of PKA phosphorylated human RyR2 in the closed state in the presence of Calmodulin
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 7u9t
Q-score: 0.427
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Complex of ryr2, calstabin-2, and calmodulin (Complex)
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b, calmodulin-1 (Complex from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of Calmodulin
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7ua3
Q-score: 0.447
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Complex of ryr2-r2474s, calstabin-2, and calmodulin (Complex)
- Zinc ion (65 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b, calmodulin-1 (Complex from Homo sapiens)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7ua4
Q-score: 0.456
Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
- Ryanodine receptor 2 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (e.c.5.2.1.8), calmodulin-1 (Complex from Homo sapiens)
- Complex of ryr2-r2474s, calstabin-2, and calmodulin (Complex)
- Zinc ion (65 Da, Ligand)
- Xanthine (152 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryanodine receptor 2 (565 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
A drug and ATP binding site in type 1 ryanodine receptor
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 7tzc
Q-score: 0.54
Melville Z, Dridi H, Yuan Q, Reiken S, Wronska A, Liu Y, Clarke OB, Marks AR
Structure (2022) 30 pp. 1025- [ Pubmed: 35580609 DOI: doi:10.1016/j.str.2022.04.010 ]
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (2s)-3-(octadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (788 Da, Ligand)
- Ryanodine receptor 1 complex with calmodulin and calstabin-1 (2 MDa, Complex from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl]benzoic acid (329 Da, Ligand)
- Calcium ion (40 Da, Ligand)